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ChemicalBook >> CAS DataBase List >>Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-

Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-

Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro- Structure
Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro- structure
CAS No.
711085-63-1
Chemical Name:
Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-
Synonyms
PNU 282987 free base;(R)-4-Chloro-N-(quinuclidin-3-yl)benzamide;4-chloro-N-[(3R)-quinuclidin-3-yl]benzamide;Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-;N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-4-chlorobenzamide
CBNumber:
CB23268809
Molecular Formula:
C14H17ClN2O
Molecular Weight:
264.75
MDL Number:
MFCD08703110
MOL File:
711085-63-1.mol
Last updated:2025-04-17 18:22:24
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Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro- Properties

Boiling point 431.5±30.0 °C(Predicted)
Density 1.27±0.1 g/cm3(Predicted)
solubility DMF: 10 mg/ml; DMSO: 30 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 5 mg/ml
form A crystalline solid
pka 13.86±0.20(Predicted)
FDA UNII 27M563MU5U

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro- price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 17424 PNU 282987 ≥98% 711085-63-1 5mg $45 2024-03-01 Buy
Cayman Chemical 17424 PNU 282987 ≥98% 711085-63-1 10mg $85 2024-03-01 Buy
Cayman Chemical 17424 PNU 282987 ≥98% 711085-63-1 25mg $166 2024-03-01 Buy
Cayman Chemical 17424 PNU 282987 ≥98% 711085-63-1 50mg $308 2024-03-01 Buy
TRC P653463 PNU-282987 711085-63-1 25mg $140 2021-12-16 Buy
Product number Packaging Price Buy
17424 5mg $45 Buy
17424 10mg $85 Buy
17424 25mg $166 Buy
17424 50mg $308 Buy
P653463 25mg $140 Buy

Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro- Chemical Properties,Uses,Production

Uses

PNU-282987 is a highly selective α7 nicotinic acetylcholine receptor agonist (1,2). PNU-282,987 has been utilized to generate retinal neurons in the absence of retinal injury or exogenous growth factors in rat (1). PNU-282,987 has the potential to reverse vision loss due to neurodegenerative disease or aging.

Definition

ChEBI: N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-4-chlorobenzamide is a carbonyl compound and an organohalogen compound.

in vivo

PNU-282987 (free base) (Compound C7) (i.v.; 1, 3 mg/kg) leads to a reversal of the gating deficit[1].
PNU-282987 (30 μM) evokes currents in rat hippocampal neurons in a concentration-dependent and MLA blockable manner[1].

Animal Model:Rats[1]
Dosage:1, 3 mg/kg
Administration:i.v.
Result:Significantly reversed amphetamine-induced gating deficit.

IC 50

5-HT3 Receptor

storage

Store at RT

Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro- Suppliers

Global( 37)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Nanjing Doge Biomedical Technology Co., Ltd 		+86-25-58227606 +86-15305155328 sales@dogechemical.com China 4128 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24727 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
TOKYO CHEMICAL INDUSTRY CO., LTD. 03-36680489 Sales-JP@TCIchemicals.com Japan 28387 80
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 71829 60
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 6345 55
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 2853530910@QQ.com China 8011 62
Supplier Advantage
TargetMol Chemicals Inc. 		58
InvivoChem 		58
Nanjing Doge Biomedical Technology Co., Ltd 		58
LEAP CHEM CO., LTD. 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
TOKYO CHEMICAL INDUSTRY CO., LTD. 80
Shanghai YuanYe Biotechnology Co., Ltd. 60
Tianjin Kailiqi Biotechnology Co., Ltd. 55
ShangHai Biochempartner Co.,Ltd 62

View Lastest Price from Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PNU-282987 free base pictures 2024-11-12 PNU-282987 free base
711085-63-1
 US $50.00-213.00 / mg 99.64% 10g TargetMol Chemicals Inc.

711085-63-1(Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-)Related Search:

N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE PNU-282987 S enantiomer hydrochloride PNU-282987 (S enantiomer free base)
Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro- 4-chloro-N-[(3R)-quinuclidin-3-yl]benzamide PNU 282987 free base N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-4-chlorobenzamide (R)-4-Chloro-N-(quinuclidin-3-yl)benzamide 711085-63-1