Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>N-Hydroxyphthalimide

N-Hydroxyphthalimide

N-Hydroxyphthalimide Structure
N-Hydroxyphthalimide structure
CAS No.
524-38-9
Chemical Name:
N-Hydroxyphthalimide
Synonyms
nhpi;2-hydroxyisoindoline-1,3-dione;hydroxyphthalimide;2-hydroxyisoindole-1,3-dione;1H-Isoindole-1,3(2H)-dione, 2-hydroxy-;HOPHT;H-HYDROXY PHTHALIMIDE;2-Hydroxy-1H-isoindole-1,3(2H)-dione;2-hydroxy-2,3-dihydro-1H-isoindole-1,3-dione;f802
CBNumber:
CB2332640
Molecular Formula:
C8H5NO3
Molecular Weight:
163.13
MDL Number:
MFCD00005891
MOL File:
524-38-9.mol
MSDS File:
SDS
Last updated:2024-12-18 14:07:02
Request For Quotation

N-Hydroxyphthalimide Properties

Melting point 233 °C (dec.) (lit.)
Boiling point 290.19°C (rough estimate)
Density 1.64 g/cm3
vapor pressure 0Pa at 25℃
refractive index 1.5510 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Powder
pka 6.10±0.20(Predicted)
color Yellow
Water Solubility Slightly soluble in water.
Merck 14,4838
BRN 131208
InChIKey CFMZSMGAMPBRBE-UHFFFAOYSA-N
LogP 0.14
CAS DataBase Reference 524-38-9(CAS DataBase Reference)
FDA UNII BXI99M81X0
EPA Substance Registry System 1H-Isoindole-1,3(2H)-dione, 2-hydroxy- (524-38-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H335-H315-H319
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
RTECS  TI5200000
TSCA  Yes
HazardClass  IRRITANT
HS Code  29251995
NFPA 704
1
2 0

N-Hydroxyphthalimide price More Price(51)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich H53704 N-Hydroxyphthalimide 97% 524-38-9 5g $24.8 2024-03-01 Buy
Sigma-Aldrich H53704 N-Hydroxyphthalimide 97% 524-38-9 100g $49 2024-03-01 Buy
TCI Chemical H0395 N-Hydroxyphthalimide >99.0%(T) 524-38-9 25g $17 2024-03-01 Buy
TCI Chemical H0395 N-Hydroxyphthalimide >99.0%(T) 524-38-9 100g $46 2024-03-01 Buy
Alfa Aesar A13862 N-Hydroxyphthalimide, 98+% 524-38-9 100g $43.7 2024-03-01 Buy
Product number Packaging Price Buy
H53704 5g $24.8 Buy
H53704 100g $49 Buy
H0395 25g $17 Buy
H0395 100g $46 Buy
A13862 100g $43.7 Buy

N-Hydroxyphthalimide Chemical Properties,Uses,Production

Chemical Properties

N-Hydroxyphthalimide is yellow moist powder

Uses

Catalyst for oxidation reactions.

Uses

Aerobic oxidation of various alcohols has been accomplished by using a new catalytic system, N-hydroxyphthalimide (NHPI) combined with Co (acac). A practical catalytic method to convert alkylbenzenes into the corresponding carboxylic acids under atmospheric dioxygen at ambient temperature using a combined catalytic system consisting of N-hydroxyphthalimide (NHPI) and Co (OAc) 2 was developed. Novel catalysis by N-hydroxyphthalimide in the oxidation of organic substrates by molecular oxygen was described. Free radical functionalization of organic compounds catalyzed by N-hydroxyphthalimide. Purely organic and catalytic systems of anthraquinones and N-hydroxyphthalimide efficiently promote oxygenation of hydrocarbons with dioxygen under mild conditions. Hydroxylation of polycyclic alkanes with molecular oxygen catalyzed by N-hydroxyphthalimide (NHPI) combined with was transition metal salts.

Uses

N-Hydroxyphthalimide，additives in to DCC method of peptide synthesis used to improve yield of optically pure product.

Application

N-Hydroxyphthalimide is used in the synthesis of a new class of antibacterials potent against macrolide resistant bacteria. Also used in the synthesis of pyrazolidines, isoxazolidines and tetrahydrooxazines.

Synthesis Reference(s)

Tetrahedron Letters, 37, p. 2035, 1996 DOI: 10.1016/0040-4039(96)00211-0

Purification Methods

N -Hydroxyphthalimide [524-38-9] M 163.1, m 230o, ~235o(dec), 237-240o, 7.0. Dissolve the imide in H2O by adding Et3N to form the salt and while hot, acidify, cool and pour into a large volume of H2O. Filter off the solid, wash it with H2O and dry it over P2O5 in a vacuum. [Nefken & Teser J Am Chem Soc 83 1263 1961, Fieser 1 485 1976, Nefkens et al. Recl Trav Chim, Pays-Bas 81 683 1962] The O-acetyl derivative has m 178-180o (from EtOH). [Beilstein 21/11 V 100.]

N-Hydroxyphthalimide Preparation Products And Raw materials

Raw materials

2H-Isoindole-2-carboxylic acid, 1,3-dihydro-1,3-dioxo-, 1,1-dimethylethyl ester 1,3-dioxoisoindolin-2-yl acetate Benzenebutanoic acid, α-methylene-, ethyl ester Benzoic acid, 2-[(hydroxyamino)carbonyl]- 2,4-DIPHENYL-1-BUTENE-D5
Fmoc-Phe-OH 2-phenylmethoxyisoindole-1,3-dione 2,4-Diphenyl-4-methyl-1-pentene Phthaloyl dichloride

1of2

Preparation Products

TERT-BUTYL N-(BENZYLOXY)CARBAMATE 1-Adamantanol synthetic tanning agent No.742 5-Hydroxy-1,4-naphthalenedione 1,3-Adamantanediol
O-(2,3,4,5,6-PENTAFLUOROBENZYL)HYDROXYLAMINE HYDROCHLORIDE synthetic tanning agent HV 1H-Isoindol-1-one, 3-hydroxy- N-(METHYLTHIO)PHTHALIMIDE 97

1of2

N-Hydroxyphthalimide Suppliers

Global( 593)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Weibang Biotechnology Co., Ltd 		+8615531157085 abby@weibangbio.com China 8810 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5889 58
Hebei Weibang Biotechnology Co., Ltd 		+8617732866630 bess@weibangbio.com China 18150 58
Hebei Kingfiner Technology Development Co.Ltd 		+86-15532196582 +86-15373005021 lisa@kingfinertech.com China 3010 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 10986 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20284 58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		+8618092446649 sarah@tnjone.com China 1143 58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		+8613343047651 admin@zlchemi.com China 3002 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29791 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 18751 58
Supplier Advantage
Hebei Weibang Biotechnology Co., Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Hebei Weibang Biotechnology Co., Ltd 		58
Hebei Kingfiner Technology Development Co.Ltd 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58

View Lastest Price from N-Hydroxyphthalimide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-Hydroxyphthalimide pictures 2024-12-23 N-Hydroxyphthalimide
524-38-9
 US $120.00 / kg 1kg 99% 20ton Hebei Zhuanglai Chemical Trading Co.,Ltd
N-Hydroxyphthalimide pictures 2024-12-13 N-Hydroxyphthalimide
524-38-9
 US $0.00 / Kg/Drum 1KG 99%min 1000kgs WUHAN FORTUNA CHEMICAL CO., LTD
N-Hydroxyphthalimide pictures 2024-11-22 N-Hydroxyphthalimide
524-38-9
 US $10.00 / kg 1kg 99% 10 mt Hebei Weibang Biotechnology Co., Ltd

N-Hydroxyphthalimide Spectrum

N-Hydroxyphthalimide(524-38-9)MSN-Hydroxyphthalimide(524-38-9)1HNMRN-Hydroxyphthalimide(524-38-9)IR1N-Hydroxyphthalimide(524-38-9)IR2N-Hydroxyphthalimide(524-38-9)Raman

524-38-9(N-Hydroxyphthalimide)Related Search:

N-Hydroxysuccinimide O-Phthalimide Bismaleimide 4-Nitrophthalimide Phthalhydrazide
N-Hydroxysulfosuccinimide sodium salt Succinimide N-Methylphthalimide 1,2-Cyclohexanedicarboximide 4-Aminophthalimide
Potassium phthalimide HOAt N-Isopropylacrylamide CAPRYLOHYDROXAMIC ACID N-Hydroxyacetamidine
D-Threo-Dihydroxyphenylserine MLMBILXCWROGFT-YVOIDUNUSA-N Droxidopa Impurity 4

1of4

TIMTEC-BB SBB009098 N-HYDROXY-PHTALIMIDE N-HYDROXYPHTHALIMIDE 2-hydroxy-1h-isoindole-3(2h)-dione N-Hydroxyphthalimide, remainder 10-15% moisture N-Hydroxyphehtalimide N-HYDROXYMETHYL-3-METHYLOXETANE N-Hydroxyphthalimide(Nop) N-Hydroxyphthalimide,98+% N-Hydroxyphthalimide,99% N-Hydroxymethyl-3-methyloxetane（N-Hydroxyphthalimide N-(hydroxy)phthaltmde N-HYDROXYPHTHALIMIDE pure PHTHALOXIME 2-Hydroxy-2H-isoindole-1,3-dione Phthalimidyl alcohol NHPI NOP N-Hydroxyphthalimide, remainder 10-15% moisture,99% N-(hydroxy)phthaltmd N-(HYDROCU)PHTHALIMDE 2-hydroxyphthalimide Phthalimide,N-hydroxy- N-Hydroxyphthalimide N-Hydroxyphthalimide Vetec(TM) reagent grade, 97% N-Hydroxyphthalimide≥ 99% (Assay) f802 n-hydroxy-phthalimid AURORA KA-3774 LABOTEST-BB LT00005723 N-HYDROXYPHTHALIMIDE FOR SYNTHESIS 2-Hydroxy-1H-isoindole-1,3(2H)-dione, 2-Hydroxyisoindolin-1,3-dione N - hydroxy phthalates forMyl aMine N-HydroxyphthaL N-Hydroxyphthalimide> N-Hydroxyphthalimide, 98%, for synthesis Droxidopa Impurity 14 N-Hydroxyphthalimide USP/EP/BP 1H-Isoindole-1,3(2H)-dione, 2-hydroxy- nhpi 2-hydroxyisoindole-1,3-dione 2-hydroxyisoindoline-1,3-dione 2-Hydroxy-1H-isoindole-1,3(2H)-dione hydroxyphthalimide HOPHT H-HYDROXY PHTHALIMIDE 2-hydroxy-2,3-dihydro-1H-isoindole-1,3-dione N-Hydrophthalimide Drxidopa impurity 11 524-38-9 Carbon Radical Producing Catalysts (Environmentally-friendly Oxidation) Peptide Synthesis Condensation & Active Esterification Coupling Reactions (Peptide Synthesis) Coupling Synthetic Reagents Environmentally-friendly Oxidation N-Substituted Maleimides, Succinimides & Phthalimides N-Substituted Phthalimides