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7-Dehydrocholesterol-25,26,26,26,27,27,27-d7

CAS No.
388622-58-0
Chemical Name:
7-Dehydrocholesterol-25,26,26,26,27,27,27-d7
Synonyms
7-dehydro Cholesterol-d7;2H7]-7-Dehydrocholesterol;(3β)-7-Dehydro Cholesterol-d7 (Major);(32)-7-Dehydro Cholesterol-d7 (Major);7-Dehydrocholesterol-25,26,26,26,27,27,27-d7;(3β)-7-Dehydro Cholesterol-d7 (See also D229462);Cholesta-5,7-dien-25,26,26,26,27,27,27-d7-3-ol, (3b)-;Cholecalciferol EP Impurity B-d7 (3-beta-7-Dehydro Cholesterol-d7)
CBNumber:
CB23335585
Molecular Formula:
C27H44O
Molecular Weight:
384.65
MDL Number:
MFCD22570234
MOL File:
388622-58-0.mol
MSDS File:
SDS
Last updated:2023-05-18 11:31:13

7-Dehydrocholesterol-25,26,26,26,27,27,27-d7 Properties

storage temp. -70°C
solubility Soluble in methanol(warmed), slightly soluble in chloroform
form solid
Stability Light Sensitive

SAFETY

Risk and Safety Statements

WGK Germany  3

7-Dehydrocholesterol-25,26,26,26,27,27,27-d7 price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 774898 7-Dehydrocholesterol-25,26,26,26,27,27,27-d7 ≥99 atom % D, ≥98% (CP) 388622-58-0 1mg $719 2024-03-01 Buy
Sigma-Aldrich 774898 7-Dehydrocholesterol-25,26,26,26,27,27,27-d7 ≥99 atom % D, ≥98% (CP) 388622-58-0 5mg $2890 2024-03-01 Buy
Cayman Chemical 25969 7-dehydro Cholesterol-d7 ≥99% deuterated forms (d1-d7) 388622-58-0 500μg $189 2024-03-01 Buy
Cayman Chemical 25969 7-dehydro Cholesterol-d7 ≥99% deuterated forms (d1-d7) 388622-58-0 1mg $340 2024-03-01 Buy
TRC D229457 (3β)-7-DehydroCholesterol-d7 388622-58-0 0.5mg $180 2021-12-16 Buy
Product number Packaging Price Buy
774898 1mg $719 Buy
774898 5mg $2890 Buy
25969 500μg $189 Buy
25969 1mg $340 Buy
D229457 0.5mg $180 Buy

7-Dehydrocholesterol-25,26,26,26,27,27,27-d7 Chemical Properties,Uses,Production

Uses

7-dehydrocholesterol-d7 has been used:

  • as an internal standard: to spike Chlamydomonas CC-125 lipid extract for mass spectroscopy analysis
  • in liquid chromatography–mass spectrometry (LC-MS) for cultured cells oxysterol analysis
  • to treat and label SRD-1 cell (chinese hamster ovary (CHO) mutant cell-line) for gas chromatography/mass spectrometry (GC/MS) analysis

General Description

7-dehydrocholesterol (7-DHC) is a cholesterol precursor and is localized in basal epidermal keratinocytes. 7DHC on photolysis in the presence of ultraviolet light B generates previtamin D3. The enzyme 7-dehydrocholesterol reductase (DHCR7) catalyzes the reduction of C(7-8) double bond of 7-DHC to cholesterol. 7-dehydrocholesterol-d7 is a deuterated derivative of 7-dehydrocholesterol.

Biochem/physiol Actions

7-Dehydrocholesterol (7-DHC) is used as a precursor for microbial vitamin D3 production. Impairment of 7-dehydrocholesterol reductase (DHCR7) functionality leads to 7-DHC accumulation and is implicated in Smith-Lemli-Opitz syndrome (SLOS).

7-Dehydrocholesterol-25,26,26,26,27,27,27-d7 Preparation Products And Raw materials

Raw materials

Preparation Products

7-Dehydrocholesterol-25,26,26,26,27,27,27-d7 Suppliers

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7-Dehydrocholesterol-25,26,26,26,27,27,27-d7 (3β)-7-Dehydro Cholesterol-d7 (See also D229462) (3β)-7-Dehydro Cholesterol-d7 (Major) Cholesta-5,7-dien-25,26,26,26,27,27,27-d7-3-ol, (3b)- 7-dehydro Cholesterol-d7 (32)-7-Dehydro Cholesterol-d7 (Major) Cholecalciferol EP Impurity B-d7 (3-beta-7-Dehydro Cholesterol-d7) 2H7]-7-Dehydrocholesterol 388622-58-0