ChemicalBook >> CAS DataBase List >>Selective PI3Kδ Inhibitor 1
Selective PI3Kδ Inhibitor 1
- CAS No.
- 2088525-31-7
- Chemical Name:
- Selective PI3Kδ Inhibitor 1
- Synonyms
- PI3Kδ-IN-5;compound 7n;PI3Kδ-IN-7n;PI3K delta-IN-7n;SelectivePI3KδInhibitor1;Selective PI3Kδ Inhibitor 1;SelectivePI3KδInhibitor1(compound7n);SELECTIVE PI3KΔ INHIBITOR 1;COMPOUND 7N;Benzamide, 4-[3-amino-6-[1-methyl-5-(1-phenylcyclopropyl)-1H-1,2,4-triazol-3-yl]-2-pyrazinyl]-2-fluoro-;Inhibitor,inhibit,Phosphoinositide 3-kinase,PI3K,Selective PI3Kδ Inhibitor 1,Selective PI-3Kδ Inhibitor 1
- CBNumber:
- CB23379666
- Molecular Formula:
- C23H20FN7O
- Molecular Weight:
- 429.45
- MDL Number:
- MOL File:
- 2088525-31-7.mol
Last updated:2024-07-02 08:55:03
Selective PI3Kδ Inhibitor 1 Chemical Properties,Uses,Production
Biological Activity
Selective PI3Kδ Inhibitor 1 (compound 7n) is a PI3Kδ inhibitor with IC50 of 0.9 nM for PI3Kδ, which is more than 1000-fold selective for other class I PI3K isoforms. The IC50 values of it for PI3Kα/γ/β were 3670, 1460, and 21300 nM, respectively.
in vivo
Selective PI3Kδ Inhibitor 1 has favorable pharmacokinetic profile: good bioavailability and moderate in vivo half-life. In rats, its oral bioavailability was 41%; after intravenous injection, Vss, T 1/2 and CL were 2.8 L/kg, 3.4 h and 12 mL/min/kg, respectively .
target
Target | Value |
PI3Kδ (Cell-free assay) | 0.9 nM |
Selective PI3Kδ Inhibitor 1 Preparation Products And Raw materials
Raw materials
Preparation Products
Selective PI3Kδ Inhibitor 1 Suppliers
Global( 12)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
Shanghai Beckham Medical Technology Co., Ltd | 021-13816613772 13816613772 | huahero21@sina.com | China | 377 | 55 |
Zhengzhou anmousse chemical products co. LTD | 0371-55289822 18737195735 | 483339295@qq.com | China | 7099 | 58 |
Absin Bioscience Inc. | 021-38015121 15000105423 | chenjw@absin.cn | China | 24734 | 58 |
Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5132 | 58 |
Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
Kaifeng Mingren Pharmaceutical Co.,LTD | 0371-65741762 | sales@hasunny.com | China | 2380 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
Selective PI3Kδ Inhibitor 1
SelectivePI3KδInhibitor1(compound7n)
PI3Kδ-IN-7n
compound 7n
SELECTIVE PI3KΔ INHIBITOR 1;COMPOUND 7N
PI3K delta-IN-7n
Benzamide, 4-[3-amino-6-[1-methyl-5-(1-phenylcyclopropyl)-1H-1,2,4-triazol-3-yl]-2-pyrazinyl]-2-fluoro-
SelectivePI3KδInhibitor1
Inhibitor,inhibit,Phosphoinositide 3-kinase,PI3K,Selective PI3Kδ Inhibitor 1,Selective PI-3Kδ Inhibitor 1
PI3Kδ-IN-5
2088525-31-7