| Company Name: |
Sichuan Wei Keqi Biological Technology Co., Ltd.
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| Tel: |
028-81700200 18116577057 |
| Email: |
3003855609@qq.com |
| Products Intro: |
Product Name:SelectivePI3KδInhibitor1
CAS:2088525-31-7
Purity:98% Package:5mg；10mg；20mg；50mg；100mg；200mg；500mg；1g
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| Company Name: |
Zhengzhou anmousse chemical products co. LTD
|
| Tel: |
0371-55289822 18737195735 |
| Email: |
483339295@qq.com |
| Products Intro: |
Product Name:Selective PI3Kδ Inhibitor 1
CAS:2088525-31-7
Purity:98% Package:5g;10g;25g;50g;100g
|
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| | Selective PI3Kδ Inhibitor 1 Basic information |
| Product Name: | Selective PI3Kδ Inhibitor 1 | | Synonyms: | Selective PI3Kδ Inhibitor 1;SelectivePI3KδInhibitor1(compound7n);PI3Kδ-IN-7n;compound 7n;SELECTIVE PI3KΔ INHIBITOR 1;COMPOUND 7N;PI3K delta-IN-7n;Benzamide, 4-[3-amino-6-[1-methyl-5-(1-phenylcyclopropyl)-1H-1,2,4-triazol-3-yl]-2-pyrazinyl]-2-fluoro-;SelectivePI3KδInhibitor1 | | CAS: | 2088525-31-7 | | MF: | C23H20FN7O | | MW: | 429.45 | | EINECS: | | | Product Categories: | | | Mol File: | 2088525-31-7.mol |  |
| | Selective PI3Kδ Inhibitor 1 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO: 43 mg/mL (100.13 mM);Ethanol: Insoluble | | form | Solid | | color | Off-white to gray | | Water Solubility | Water: Insoluble |
| | Selective PI3Kδ Inhibitor 1 Usage And Synthesis |
| Biological Activity | Selective PI3Kδ Inhibitor 1 (compound 7n) is a PI3Kδ inhibitor with IC50 of 0.9 nM for PI3Kδ, which is more than 1000-fold selective for other class I PI3K isoforms. The IC50 values of it for PI3Kα/γ/β were 3670, 1460, and 21300 nM, respectively. | | in vivo | Selective PI3Kδ Inhibitor 1 has favorable pharmacokinetic profile: good bioavailability and moderate in vivo half-life. In rats, its oral bioavailability was 41%; after intravenous injection, Vss, T 1/2 and CL were 2.8 L/kg, 3.4 h and 12 mL/min/kg, respectively . | | target | | Target | Value | PI3Kδ
(Cell-free assay) | 0.9 nM |
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| | Selective PI3Kδ Inhibitor 1 Preparation Products And Raw materials |
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