2,4,6-Tri-tert-butylphenol
- CAS No.
- 732-26-3
- Chemical Name:
- 2,4,6-Tri-tert-butylphenol
- Synonyms
- 2,4,6-Tris(tert-butyl)phenol;Phenol, 2,4,6-tri-tert-butyl-;P23;Phenol,2,4,6-tri-tert-butyl-;P 23;TM02;CRYA2;NCK5A;Voidox;CDK5P35
- CBNumber:
- CB2357818
- Molecular Formula:
- C18H30O
- Molecular Weight:
- 262.43
- MDL Number:
- MFCD00008821
- MOL File:
- 732-26-3.mol
- MSDS File:
- SDS
| Melting point | 125-130 °C (lit.) |
|---|---|
| Boiling point | 277 °C (lit.) |
| Density | 0.8640 |
| vapor pressure | 0.073Pa at 25℃ |
| refractive index | 1.5029 (estimate) |
| Flash point | 130 °C |
| storage temp. | -70°C |
| solubility | Chloroform (Slightly), DMSO (Slightly, Sonicated) |
| pka | 12.61±0.40(Predicted) |
| form | buffered aqueous glycerol solution |
| color | Off-White to Pale Yellow |
| biological source | rabbit |
| Water Solubility | insoluble |
| BRN | 1913256 |
| Specific Activity | 583-789nmol/min·mg |
| InChIKey | PFEFOYRSMXVNEL-UHFFFAOYSA-N |
| LogP | 7.1 at 35℃ |
| CAS DataBase Reference | 732-26-3(CAS DataBase Reference) |
| FDA UNII | 99J2VIC675 |
| NIST Chemistry Reference | Phenol, 2,4,6-tris(1,1-dimethylethyl)-(732-26-3) |
| EPA Substance Registry System | 2,4,6-Tris(tert-butyl)phenol (732-26-3) |
| UNSPSC Code | 41116107 |
| NACRES | NA.43 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H317-H360D-H373-H410 |
| Precautionary statements | P202-P273-P280-P301+P312-P302+P352-P308+P313 |
| Hazard Codes | F,C,N,Xi,Xn |
| Risk Statements | 11-22-34-50-53-36/37/38-51/53 |
| Safety Statements | 26-36/37/39-45-60-61-24/25 |
| RIDADR | UN 2430 8/PG 3 |
| WGK Germany | 3 |
| RTECS | SN3570000 |
| F | 8-23 |
| HazardClass | 9 |
| PackingGroup | III |
| HS Code | 29071990 |
| Hazardous Substances Data | 732-26-3(Hazardous Substances Data) |
| Toxicity | LD50 oral in rat: 1670mg/kg |
2,4,6-Tri-tert-butylphenol price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T49409 | 2,4,6-Tri-tert-butylphenol 98% | 732-26-3 | 100g | $126 | 2024-03-01 | Buy |
| Sigma-Aldrich | SAB4500484 | Anti-CRYAB antibody produced in rabbit affinity isolated antibody | 732-26-3 | 100μG | $506 | 2024-03-01 | Buy |
| Sigma-Aldrich | C0745 | CDK5/p25, active, GST tagged human PRECISIO? Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution | 732-26-3 | 10μG | $525 | 2023-06-20 | Buy |
| Sigma-Aldrich | SAB4500486 | Anti-CRYAB antibody produced in rabbit affinity isolated antibody | 732-26-3 | 100μG | $485 | 2023-01-07 | Buy |
| American Custom Chemicals Corporation | CHM0007865 | 2,4,6-TRI-TERT-BUTYLPHENOL 95.00% | 732-26-3 | 100G | $2501.06 | 2021-12-16 | Buy |
2,4,6-Tri-tert-butylphenol Chemical Properties,Uses,Production
Chemical Properties
Solid. Insoluble in water; soluble in most organic solvents. Combustible.
Uses
2,4,6-Tri-tert-butylphenol is an antioxidant; used in preparation method of high-temperature resistant electromagnetic shielding electromagnetic bushing.
Flammability and Explosibility
Non flammable
Biological Activity
CDK5 is a member of the Cyclin-Dependent Kinase family th at is most abundant in the mammalian brain. Active form of CDK5, which has also been called neuronal cdc2-like kinase, is a heterodimer of CDK5 and a 25 kDa protein which is derived proteolytically from a 35 kDa brain and neuron-specific protein and is essential for the kinase activity of CDK5. CDK5 has emerged as a crucial regulator of neuronal migration in the developing central nervous system. CDK5 phosphorylates a diverse list of substrates, implicating it in the regulation of a range of cellular processes - from adhesion and motility, to synaptic plasticity and drug addiction.
Purification Methods
Distil the phenol under reduced pressure and/or recrystallise it from n-hexane or several times from 95% EtOH until the EtOH solution is colourless [Balasubramanian & Bruice J Am Chem Soc 108 5495 1986]. It has also been purified by sublimation [Yuan & Bruice J Am Chem Soc 108 1643 1986, Wong et al. J Am Chem Soc 109 3428 1987]. Purification has also been achieved by passage through a silica gel column followed by recrystallisation from n-hexane [Kajii et al. J Phys Chem 91 2791 1987]. [Beilstein 6 III 2094, 6 IV 3539.]
Toxicity evaluation
In order to study the chronic toxicity of 2,4,6-tri-tert-butylphenol (TTBP), groups of 40 Slc: Wistar rats of either sex were fed a diet containing 0, 30, 100, 300, or 1000 ppm of TTBP for up to 24 months. Hematological, biochemical, and histopathological examinations performed periodically revealed slight microcytic anemia, changes in some biochemical parameters relating to liver function, and focal necrosis of liver cells following TTBP administration, and these changes observed in females were more severe than those in males. No neoplastic responses following TTBP administration were noted. Hence, it was concluded that TTBP causes liver injury characterized by focal necrosis with microcytic anemia and elevations of serum phospholipids and cholesterol levels, presumably occurring as secondary effects following the liver injury[1].
References
[1] Matsumoto, Kiyoshi , et al. "Chronic toxicity of 2,4,6-tri-tert-butylphenol in rats." Journal of Toxicological Sciences 16.4(1991):167.
2,4,6-Tri-tert-butylphenol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| NANJING PASTEUR ChEMICAL CO.,LTD | +86-18066069912 +86-18066069912 | 1390310770@qq.com | China | 18 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531157085 | abby@chuanghaibio.com | China | 8808 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12806 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5868 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18137 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21628 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Chemson Industrial (Shanghai) Co., Ltd. | 86-21-65208861- 8007 | sales1@chemson.com.cn | CHINA | 117 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29858 | 58 |
View Lastest Price from 2,4,6-Tri-tert-butylphenol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-28 | 2,4,6-Tri-tert-butylphenol
732-26-3
|
US $5.00 / kg | 1kg | ≥99% | 1000mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2025-04-23 | 2,4,6-Tri-tert-butylphenol
732-26-3
|
US $0.00-0.00 / KG | 1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-04-15 | 2,4,6-Tri-tert-butylphenol
732-26-3
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 2,4,6-Tri-tert-butylphenol
732-26-3
- US $5.00 / kg
- ≥99%
- Jinan Finer Chemical Co., Ltd
-
- 2,4,6-Tri-tert-butylphenol
732-26-3
- US $0.00-0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 2,4,6-Tri-tert-butylphenol
732-26-3
- US $0.00-0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd