ChemicalBook >> CAS DataBase List >>3-(4-bromophenyl)-6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[2,3-c][1,2,4]triazole

3-(4-bromophenyl)-6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[2,3-c][1,2,4]triazole

3-(4-bromophenyl)-6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[2,3-c][1,2,4]triazole structure

CAS No.: 862808-01-3

Chemical Name:: 3-(4-bromophenyl)-6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[2,3-c][1,2,4]triazole

Synonyms: FSEN1;3-(4-bromophenyl)-6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[2,3-c][1,2,4]triazole;Thiazolo[2,3-c]-1,2,4-triazole, 3-(4-bromophenyl)-6-[[4-(4-methoxyphenyl)-1-piperazinyl]methyl]-;1-{[3-(4-bromophenyl)-[1,2,4]triazolo[3,4-b][1,3]thiazol-6-yl]methyl}-4-(4-methoxyphenyl)piperazine

CBNumber:: CB23733345

Molecular Formula:: C22H22BrN5OS

Molecular Weight:: 484.41

MDL Number:: MFCD05897677

MOL File:: 862808-01-3.mol

Last updated:2024-07-02 08:55:03

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3-(4-bromophenyl)-6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[2,3-c][1,2,4]triazole Properties

Density	1.52±0.1 g/cm3(Predicted)
solubility	DMF: 1 mg/ml; DMSO: Slightly soluble
form	A crystalline solid
pka	6.56±0.10(Predicted)
color	Off-white to light yellow

3-(4-bromophenyl)-6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[2,3-c][1,2,4]triazole Chemical Properties,Uses,Production

Description

FSEN1 is an inhibitor of ferroptosis suppressor protein 1 (FSP1; IC₅₀ = 313 nM).¹ It is selective for FSP1 over NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1; IC₅₀ = >100 μM). FSEN1 induces cell death in GPX4^-/- H460 non-small cell lung cancer (NSCLC) cells (EC₅₀ = 69.36 nM) but not control H460 cells expressing Cas9 (H460Cas9). It sensitizes A549, Huh7, HCC1143, U2OS, SU-DHL-5, and T98G cancer cells to ferroptosis induced by (1S,3R)-RSL3 when used at concentrations ranging from 10 to 1,000 nM. FSEN1 also sensitizes H460Cas9 cells, but not FSP1^-/- H460 cells, to cell death induced by the ferroptosis inhibitors dihydroartemisinin or FINO₂ .

References

1. Hendricks, J.M., Doubravsky, C., Wehri, E., et al. Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis bioRxiv ,(2022).

3-(4-bromophenyl)-6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[2,3-c][1,2,4]triazole Preparation Products And Raw materials

Raw materials

Preparation Products

3-(4-bromophenyl)-6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[2,3-c][1,2,4]triazole Suppliers

Global( 7)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9941	58
Suzhou Chenrui Biotechnology Co. LTD	17625585511	1580084073@qq.com	China	537	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	4578	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	28091	58

Supplier	Advantage
LEAPCHEM CO., LTD.	58
Shanghai Chaolan Chemical Technology Center	58
Suzhou Chenrui Biotechnology Co. LTD	58
Nantong QuanYi Biotechnology Co., Ltd	58
TargetMol Chemicals Inc.	58

3-(4-bromophenyl)-6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[2,3-c][1,2,4]triazole FSEN1 Thiazolo[2,3-c]-1,2,4-triazole, 3-(4-bromophenyl)-6-[[4-(4-methoxyphenyl)-1-piperazinyl]methyl]- 1-{[3-(4-bromophenyl)-[1,2,4]triazolo[3,4-b][1,3]thiazol-6-yl]methyl}-4-(4-methoxyphenyl)piperazine 862808-01-3