Nitrendipine
- CAS No.
- 39562-70-4
- Chemical Name:
- Nitrendipine
- Synonyms
- Nitrendipin;3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;Deiten;nidrel;Nitrepin;baye5009;baypress;bayotensin;Bylotensin;NITRENDIPINE
- CBNumber:
- CB2395104
- Molecular Formula:
- C18H20N2O6
- Molecular Weight:
- 360.36
- MDL Number:
- MFCD00082255
- MOL File:
- 39562-70-4.mol
- MSDS File:
- SDS
Melting point | 1580C |
---|---|
Boiling point | 492.4°C (rough estimate) |
Density | 1.3595 (rough estimate) |
refractive index | 1.5700 (estimate) |
storage temp. | 2-8°C |
solubility | methanol: 15 mg/mL |
form | powder |
pka | 2.79±0.70(Predicted) |
color | yellow to green |
Water Solubility | Soluble in DMSO (17.5 mg/ml), methanol (15 mg/ml), ethyl acetate, and ethanol (25 mM). Insoluble in water. |
Stability | Stable for 1 year from date of purchase as supplied. Protect from light. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 week. |
CAS DataBase Reference | 39562-70-4(CAS DataBase Reference) |
FDA UNII | 9B627AW319 |
ATC code | C08CA08 |
NIST Chemistry Reference | Nitrendipine(39562-70-4) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H312-H332 | |||||||||
Precautionary statements | P261-P280h-P301+P312a-P304+P340-P321-P501a | |||||||||
Hazard Codes | Xn | |||||||||
Risk Statements | 20/21/22 | |||||||||
Safety Statements | 36 | |||||||||
WGK Germany | 1 | |||||||||
RTECS | US5653000 | |||||||||
Toxicity | LD50 in mice, rats (mg/kg): 39, 12.6 i.v.; 2540, >10000 orally (Hoffmann) | |||||||||
NFPA 704 |
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Nitrendipine price More Price(45)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | N144 | Nitrendipine >95%, powder | 39562-70-4 | 25mg | $95.3 | 2024-03-01 | Buy |
Sigma-Aldrich | N144 | Nitrendipine >95%, powder | 39562-70-4 | 100mg | $314 | 2024-03-01 | Buy |
Alfa Aesar | J60841 | Nitrendipine | 39562-70-4 | 100mg | $160.65 | 2024-03-01 | Buy |
Alfa Aesar | J60841 | Nitrendipine | 39562-70-4 | 1g | $570.65 | 2024-03-01 | Buy |
Cayman Chemical | 17549 | Nitrendipine ≥95% | 39562-70-4 | 10mg | $32 | 2024-03-01 | Buy |
Nitrendipine Chemical Properties,Uses,Production
Description
Nitrendipine is a vasodilating, dihydropyridine calcium antagonist. Its prolonged therapeutic effect in comparison to nifedipine makes it useful in the once to twice daily treatment of hypertension.
Chemical Properties
Crystalline Solid
Originator
Bayer (W. Germany)
Uses
Antihypertensive;Calcium channel blocker
Uses
Nitrendipine modulates NMDA receptor channel function in mammalian neurons. Nitrendipine has been shown to inhibit neutrophil adhesion to vascular endothelium. It is used in the treatment of primary hypertension to decrease blood pressure. Nitrendipine is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina.
Uses
Nitrendipine is a dihydropyridine calcium channel blocker. Nitrendipine is used in the treatment of primary (essential) hypertension to decrease blood pressure. Antihypertensive.
Definition
ChEBI: A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in t e treatment of hypertension.
brand name
Baypress (Bayer);BAYOTENSIN.
General Description
Nitrendipine, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid methyl ethylester (Baypress), is a second-generation dihydropyridinechannel blocker of the nifedipine type. It is more selectivefor vascular smooth muscle than for myocardial tissue andserves as an effective vasodilator. The drug is used in thetreatment of mild-to-moderate essential hypertension.
Biological Activity
L-type calcium channel blocker.
Biochem/physiol Actions
Ca2+ channel blocker; anti-hypertensive.
storage
Store at RT
References
1) Meyer et al., (1981), (Synthesis and comparative pharmacological studies of 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylates with non-identical ester functions); Arzneimittelforschung 31 407 2) Stoepel et al., (1981), Pharmacological studies of the antihypertensive effect of nitrendipine; Arzneimittelforschung 31 2056
Nitrendipine Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 | bruce@xrdchem.cn | CHINA | 566 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29880 | 58 |
Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2136 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 17777 | 58 |
Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8618959220845 | sales@amoychem.com | China | 6383 | 58 |
HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 | faith@widelychemical.com | CHINA | 742 | 58 |
Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
View Lastest Price from Nitrendipine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-12-20 | Nitrendipine
39562-70-4
|
US $0.00-0.00 / kg | 1kg | 99% | 20tons | Sinoway Industrial co., ltd. | ||
2024-12-13 | Nitrendipine
39562-70-4
|
US $1.00 / g | 1g | 98.5~101.5%,BP2010 | 10kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
2024-11-16 | Nitrendipine
39562-70-4
|
US $32.00-65.00 / mg | 99.54% | 10g | TargetMol Chemicals Inc. |
- Nitrendipine
39562-70-4
- US $0.00-0.00 / kg
- 99%
- Sinoway Industrial co., ltd.
- Nitrendipine
39562-70-4
- US $1.00 / g
- 98.5~101.5%,BP2010
- WUHAN FORTUNA CHEMICAL CO., LTD
- Nitrendipine
39562-70-4
- US $32.00-65.00 / mg
- 99.54%
- TargetMol Chemicals Inc.