Benidipine
- CAS No.
- 105979-17-7
- Chemical Name:
- Benidipine
- Synonyms
- BENIDIPINE HCL;(R*,R*)-(±)-(3,5-Pyridinedicarboxylic acid 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-methyl 1- (phenylmethyl)-3-piperidinyl ester monohydrochloride;KW-3049;5-O-[(3R)-1-benzylpiperidin-3-yl] 3-O-methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-, 3-Methyl5-[(3R)-1-(phenylMethyl)-3-piperidinyl] ester, (4R)-rel-;CONIEL;CAPADIPINE;BENIDIPINE;NACADIPINE;rac Benidipine
- CBNumber:
- CB2131201
- Molecular Formula:
- C28H31N3O6
- Molecular Weight:
- 505.56
- MDL Number:
- MFCD00906929
- MOL File:
- 105979-17-7.mol
- MSDS File:
- SDS
Boiling point | 625.2±55.0 °C(Predicted) |
---|---|
Density | 1.29±0.1 g/cm3(Predicted) |
pka | pKa 7.34(H2O(long extrapolation) ) (Uncertain) |
Water Solubility | 316μg/L at 25℃ |
LogP | 4.61 |
CAS DataBase Reference | 105979-17-7(CAS DataBase Reference) |
FDA UNII | 4G9T91JS7E |
ATC code | C08CA15 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS06 |
---|---|
Signal word | Danger |
Hazard statements | H301 |
Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 |
Benidipine price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | B157508 | racBenidipine | 105979-17-7 | 0.5mg | $45 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0002106 | CONIEL 95.00% | 105979-17-7 | 100MG | $693 | 2021-12-16 | Buy |
Medical Isotopes, Inc. | 18512 | Benidipine | 105979-17-7 | 25mg | $1500 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0002106 | CONIEL 95.00% | 105979-17-7 | 1G | $1501.5 | 2021-12-16 | Buy |
AvaChem | 3003B | Benidipine | 105979-17-7 | 100mg | $89 | 2021-12-16 | Buy |
Benidipine Chemical Properties,Uses,Production
Uses
Benidipine (CAS# 105979-17-7) is a 1,4-dihydropyridine and a calcium channel antagonist. Antihypertensive.
Enzyme inhibitor
This oral, once-daily antihypertensive agent (FW = 505.57 g/mol; CAS 105979-17-7), also known by its code name KW-3049, trade name Coniel?, and systematic name O -methyl,O -[(3R)-1-(phenylmethyl)piperidin-3-yl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, is a dihydropyridine-class calcium ion blocker that is effective against L-, N-, and T-channels, with potent and selective inhibitory action on cardiac slow calcium channels. Benidipine bound stereospecifically to nitrendipine binding sites of rat myocardium with high affinity (Ki = 0.13 nM) and to the rat brain a1-adrenergic receptor (Ki = 1.2 μM). KW-3049 exhibited no remarkable binding affinity to a2 adrenergic, b-adrenergic, D2 dopamine, H1 histamine, S2 serotonin, A1 adenosine, A2 adenosine and muscarinic cholinergic receptors at 100 μM.
Benidipine Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5909 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12447 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 8840 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 | info@afinechem.com | China | 15395 | 58 |
Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9318 | 58 |
Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9427 | 58 |
View Lastest Price from Benidipine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2023-01-31 | Benidipine
105979-17-7
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
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2021-07-13 | Benidipine
105979-17-7
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
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2021-07-10 | Benidipine
105979-17-7
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Benidipine
105979-17-7
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Benidipine
105979-17-7
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Benidipine
105979-17-7
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd