NONACTIN
- CAS No.
- 6833-84-7
- Chemical Name:
- NONACTIN
- Synonyms
- 3584-a;a-5584;e-79-c;n-329-a;NONACTIN;ta-25-m-i;fh-3582-a;POLYNACTIN;WERRAMYCIN A;AMMONIUM IONOPHORE
- CBNumber:
- CB2424675
- Molecular Formula:
- C40H64O12
- Molecular Weight:
- 736.93
- MDL Number:
- MFCD00043039
- MOL File:
- 6833-84-7.mol
| Melting point | 147-148° |
|---|---|
| Boiling point | 890.6±65.0 °C(Predicted) |
| Density | 1.11-1.15 g/cm3 |
| storage temp. | 2-8°C |
| solubility | chloroform: soluble10mg/mL |
| form | White to off-white crystalline solid. |
| color | white to faint yellow |
| Sensitive | Moisture Sensitive |
| Merck | 13,6709 |
| BRN | 76434 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
| EWG's Food Scores | 1 |
| FDA UNII | TTP24WX8P7 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| Hazard Codes | Xi |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| RTECS | RH1685000 |
| F | 10-21 |
| HS Code | 29321900 |
| Toxicity | LD50 intravenous in mouse: 246mg/kg |
NONACTIN price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 09877 | Ammonium ionophore I Selectophore | 6833-84-7 | 50mg | $389 | 2024-03-01 | Buy |
| Sigma-Aldrich | 09877 | Ammonium ionophore I Selectophore | 6833-84-7 | 250mg | $1780 | 2024-03-01 | Buy |
| Cayman Chemical | 19468 | Nonactin ≥95% | 6833-84-7 | 5mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 19468 | Nonactin ≥95% | 6833-84-7 | 10mg | $87 | 2024-03-01 | Buy |
| Sigma-Aldrich | N2286 | Nonactin ≥98% (function tested, HPLC) | 6833-84-7 | 10mg | $188 | 2024-03-01 | Buy |
NONACTIN Chemical Properties,Uses,Production
Description
Nonactin (6833-84-7) is a monovalent cation ionophore with high selectivity for NH4+ and K+ .1 Upregulates levels of mitochondrial stress proteins HSP58 and GRP75.2 Nonactin abolishes mitochondrial membrane potential.3
Chemical Properties
Light yellow powder
Uses
Nonactin is the smallest member of the macrotetrolide complex produced by a range of Streptomyces species. Originally the name, nonactin, reflected the lack of biological activity. The literature is confusing in this respect, as virtually all sources of nonactin are contaminated with small amounts of the much more active monactin. The BioAustralis nonactin has been purified to remove traces of other biologically-active macrotetrolides. Like the other macrotetrolides, nonactin is a monovalent cation ionophore with high selectivity for ammonium and potassium.
Uses
Nonactin is an ionophore antiobiotic that selectively binds K+?and NH4+.
Definition
ChEBI: Nonactin is a macrotetrolide.
Biological Activity
Monovalent cation ionophore that displays selectivity for K + and NH 4 + (K + = NH 4 + > Na + > Mg 2+ > Li + >> Ca 2+ for nonactin-EVA sensor). Induces cation transport across artificial membranes. Also inhibits P-glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug resistant cancer cells. Antibiotic.
Purification Methods
This macrotetrolide antibiotic crystallises from MeOH as colourless needles and is dried at 90o/20hours/high vacuum. [Cordaz et al. Helv Chim Acta 38 1445 1955, crystal structure: Dobler Helv Chim Acta 55 1371 1972, Gambos et al. Tetrahedron Lett 3391 1975, Beilstein 19/12 V 751.]
References
1) Garcia et al. (2003), Determination of potassium ions in pharmaceutical samples by FIA using a potentiometric electrode based on ionophore nonactin occulded in EVA membrane; J. Pham. Biomed. Anal., 31 11 2) Mizzen et al. (1989), Identification, characterization and purification of two mammalian stress proteins present in mitochondria, grp 75, a member of the hsp 70 family and hsp 58, a homolog of the bacterial groEL protein; J. Biol. Chem., 264 20664 3) Dudani et al. (1990), Effects of antimitotic and antimitochondrial agents on the cellular distribution of microtubules and mitochondria; Cytobios, 63 95
NONACTIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29815 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 7724 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19741 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49979 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94657 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
| Beijing HwrkChemical Technology Co., Ltd | 010-89508211 18501085097 | sales.bj@hwrkchemical.com | China | 8415 | 55 |
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