Phenethyl caffeate
- CAS No.
- 104594-70-9
- Chemical Name:
- Phenethyl caffeate
- Synonyms
- CAFFEIC ACID PHENETHYL ESTER;CAFFEIC ACID PHENYLETHYL ESTER;PHENETHYL CAFFEATE;Phenylethy caffeate;PHENYLETHYL CAFFEATE;PhenethylCaffeate>Caffeic acid pheneth;2-Phenyethyl caffeate;CAPE,PhenethylCaffeate;Caffeic acid phenethyl
- CBNumber:
- CB2438898
- Molecular Formula:
- C17H16O4
- Molecular Weight:
- 284.31
- MDL Number:
- MFCD00866470
- MOL File:
- 104594-70-9.mol
- MSDS File:
- SDS
| Melting point | 127-129℃ |
|---|---|
| Boiling point | 498.6±45.0 °C(Predicted) |
| Density | 1.266±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in ethyl acetate at 50mg/ml. Soluble in DMSO and ethanol. |
| pka | 8.46±0.20(Predicted) |
| form | White to off-white solid |
| color | off-white |
| λmax | 323nm(lit.) |
| Sensitive | Light Sensitive |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| InChIKey | SWUARLUWKZWEBQ-VQHVLOKHSA-N |
| LogP | 3.734 (est) |
| CAS DataBase Reference | 104594-70-9(CAS DataBase Reference) |
| FDA UNII | G960R9S5SK |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-38-37-36 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UD3334375 | |||||||||
| HS Code | 29182900 | |||||||||
| NFPA 704 |
|
Phenethyl caffeate price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C8221 | Caffeic acid phenethyl ester ≥97% (HPLC), powder | 104594-70-9 | 1g | $637 | 2024-03-01 | Buy |
| Sigma-Aldrich | 211200 | CAPE A cell-permeable active component of propolis from honeybee hives. | 104594-70-9 | 25mg | $187 | 2024-03-01 | Buy |
| TCI Chemical | P2088 | Phenethyl Caffeate >98.0%(HPLC) | 104594-70-9 | 25mg | $24 | 2024-03-01 | Buy |
| TCI Chemical | P2088 | Phenethyl Caffeate >98.0%(HPLC) | 104594-70-9 | 250mg | $118 | 2024-03-01 | Buy |
| Alfa Aesar | J61386 | Phenylethyl 3,4-dihydroxycinnamate, 99+% | 104594-70-9 | 250mg | $120.65 | 2024-03-01 | Buy |
Phenethyl caffeate Chemical Properties,Uses,Production
Description
Phenylethyl caffeate is one of the allergens of propolis (bee glue); also contained in poplar-bud secretions.
Chemical Properties
Off-White Solid
Uses
Phenylethyl 3,4-dihydroxycinnamate is a potent and specific inhibitor of nuclear transcription factor, NF-κB, activation. It has been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation. It inhibits HIV-1 integrase and also inhibits proliferation of transformed cells. It induces apoptosis in transformed fibroblasts, and interferes with EGF signal transduction affecting both protein kinase C and ornithine decarboxylase activity.
Uses
antineoplastic, antiinflammatory, immunomodulator, NFkB blocker
Uses
Cytotoxic agent against cancer cell lines. Inhibitor of ornithine decarboxylase and protein tyrosine kinase. Found to be a specific inhibitor of the nuclear transcription factor, NF-kB. It has also been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation.
Definition
ChEBI: Phenethyl caffeate is an alkyl caffeate ester in which 2-phenylethyl is the alkyl component. It has a role as an antineoplastic agent, an anti-inflammatory agent, an immunomodulator, a metabolite, an antioxidant, a neuroprotective agent, an antiviral agent and an antibacterial agent.
Biological Activity
Antioxidant, antimitogenic, anticarcinogenic, anti-inflammatory and antiviral. Specifically inhibits NF- κ B activation and inhibits the growth of transformed cells. Also suppresses lipid peroxidation and inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities.
Biochem/physiol Actions
CAPE exhibits several properties such as anticarcinogenic, immunomodulatory activities, antioxidant, antiviral, anti-inflammatory, hypoglycaemic effect, cardioprotective and inhibits gastric secretion. It also has an inhibitory effect on fibroblasts growth factor type 2 (FGF-2), a tumor growth factor in breast cancer.
Contact allergens
Capee is one of the allergens of propolis (bee glue). It is also contained in poplar bud secretions.
Anticancer Research
Caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE) is a natural phenolcompound and an active component of propolis from honeybee hives. Torkiet al. (2017)investigated the effect of phosphatidylinositol 3-kinase/AKT/mammaliantarget of rapamycin (PI3K/Akt/mTOR) signaling pathway dual inhibitor, NVP-BEZ235,and CAPE on TNBC cell line (MDA-MB-231), stimulated withtransforming growth factor (TGF)-β1 for 14 days. CAPE in combination with NVP-BEZ235synergistically inhibited cell growth and reduced CXCR4 expression.Also, treatment of MDA-MB-231 cells with CAPE and NVP-BEZ235 time-dependentlyinhibited the expression of p-Forkhead Box O3a (FOXO3a). In a nutshell,these results indicate that tumour metastasis and progression in TNBC cellscan be effectively reduced through the concurrent use of NVP-BEZ235 and CAPE(Torki et al. 2017).
storage
Store at -20°C
References
1) Sudine et al. (1993) Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. FEBS Lett. 21 329 2) Natarajan et al. (1996) Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc. Natl. Acad. Sci. USA 93 9090 3) Chiao et al. (1995). Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells; Cancer Res. 55 3576 4) Orban et.al. (2000), Caffeic acid phenethyl ester induces leukocyte apoptosis, modulates nuclear factor-kappa B and suppresses acute inflammation; Neuroimmunomodulation, 7 99
Phenethyl caffeate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8811 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12839 | 58 |
| Hubei Langyou International Trading Co., Ltd | +86-18874586545 +86-18874586545 | linda@xrdchem.cn | China | 196 | 58 |
| Wuhan senwayer century chemical Co.,Ltd | +undefined-27-86652399 +undefined13627115097 | market02@senwayer.com | China | 902 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20287 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 | info@tnjchem.com | China | 2986 | 55 |
View Lastest Price from Phenethyl caffeate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-26 | Phenethyl caffeate
104594-70-9
|
US $10.00 / kg | 1kg | 99% | 10000 | Changsha Staherb Natural Ingredients Co., Ltd. | |
 |
2024-11-26 | Phenethyl caffeate; Propolis extract
104594-70-9
|
US $0.00 / kg | 1kg | ≥98% HPLC | 1000kg | Changsha Staherb Natural Ingredients Co., Ltd. | |
 |
2024-11-17 | Caffeic Acid Phenethyl Ester
104594-70-9
|
US $33.00-61.00 / mg | 99.35% | 10g | TargetMol Chemicals Inc. |
-
- Phenethyl caffeate
104594-70-9
- US $10.00 / kg
- 99%
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- Phenethyl caffeate; Propolis extract
104594-70-9
- US $0.00 / kg
- ≥98% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- Caffeic Acid Phenethyl Ester
104594-70-9
- US $33.00-61.00 / mg
- 99.35%
- TargetMol Chemicals Inc.