![Phenethyl caffeate](/ProductImageEN/2022-05/Large/c29b127d-80d3-49fe-8011-4cafc010a6e0.png)
Phenethyl caffeate
Price | $10 |
Package | 1kg |
Min. Order: | 1kg |
Supply Ability: | 10000 |
Update Time: | 2024-08-23 |
Product Details
Product Name: Phenethyl caffeate | CAS No.: 104594-70-9 |
Min. Order: 1kg | Purity: 99% |
Supply Ability: 10000 | Release date: 2024/08/23 |
Description | Phenylethyl caffeate is one of the allergens of propolis (bee glue); also contained in poplar-bud secretions. |
Chemical Properties | Off-White Solid |
Uses | Phenylethyl 3,4-dihydroxycinnamate is a potent and specific inhibitor of nuclear transcription factor, NF-κB, activation. It has been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation. It inhibits HIV-1 integrase and also inhibits proliferation of transformed cells. It induces apoptosis in transformed fibroblasts, and interferes with EGF signal transduction affecting both protein kinase C and ornithine decarboxylase activity. |
Uses | antineoplastic, antiinflammatory, immunomodulator, NFkB blocker |
Uses | Cytotoxic agent against cancer cell lines. Inhibitor of ornithine decarboxylase and protein tyrosine kinase. Found to be a specific inhibitor of the nuclear transcription factor, NF-kB. It has also been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation. |
Biological Activity | Antioxidant, antimitogenic, anticarcinogenic, anti-inflammatory and antiviral. Specifically inhibits NF- κ B activation and inhibits the growth of transformed cells. Also suppresses lipid peroxidation and inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities. |
Biochem/physiol Actions | CAPE exhibits several properties such as anticarcinogenic, immunomodulatory activities, antioxidant, antiviral, anti-inflammatory, hypoglycaemic effect, cardioprotective and inhibits gastric secretion. It also has an inhibitory effect on fibroblasts growth factor type 2 (FGF-2), a tumor growth factor in breast cancer. |
Contact allergens | Capee is one of the allergens of propolis (bee glue). It is also contained in poplar bud secretions. |
Anticancer Research | Caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE) is a natural phenolcompound and an active component of propolis from honeybee hives. Torkiet al. (2017)investigated the effect of phosphatidylinositol 3-kinase/AKT/mammaliantarget of rapamycin (PI3K/Akt/mTOR) signaling pathway dual inhibitor, NVP-BEZ235,and CAPE on TNBC cell line (MDA-MB-231), stimulated withtransforming growth factor (TGF)-β1 for 14 days. CAPE in combination with NVP-BEZ235synergistically inhibited cell growth and reduced CXCR4 expression.Also, treatment of MDA-MB-231 cells with CAPE and NVP-BEZ235 time-dependentlyinhibited the expression of p-Forkhead Box O3a (FOXO3a). In a nutshell,these results indicate that tumour metastasis and progression in TNBC cellscan be effectively reduced through the concurrent use of NVP-BEZ235 and CAPE(Torki et al. 2017). |
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Company Profile Introduction
Changsha Staherb Natural Ingredients Co., Ltd., a good supplier of professional herb extracts, especially those with high purity and standardized production process. Our company devotes to supply high quality products and services to customers in R&D and production fields of health products, cosmetics, feed additives and biopesticides.
With cordial and professional R&D, sales and after-sales service groups, Staherb has potent capabilities both in R&D and production. The company persists in high investment on R&D of active ingredients of plants and promotes innovation on demands of customers. Upon constant R&D and tracing of new technologies and new products, Staherb makes effective cooperation with famous research institutes, such as CAS Kunming Institute of Botany, State Key Lab of Hunan Forest Products and Chemical Engineering, Hunan Agricultural University and so on.
Now the main products of Staherb are standardized high purity plant extracts, including Epimedium (10-98%), Euccomia Bark Extract (5-95%), Amygdalin (50-98%), Ursolic acid (25-98%) and Corosolic acid (1-98%). In order to meet customers’ research needs, our company also provides over 600 plant extracts, most of which are high-purity monomer plant compounds and reference substance. And some products can be supplied with milligram-scale, kilogram-scale or even to ton-scale. In addition, based upon the powerful R&D capability, Staherb can provide both products customization services and R&D outsourcing services according to customers’ specific requirements, so that to meet their continual innovation needs in the fields of natural products’ discovery and production.
Staherb endeavors to accelerate the response rate of supply chain as well as improve the service superiority upon customers’ continual innovation needs. It also devotions to establish good partnerships with customers and to construct a safe development model which is forward-looking, reciprocal and coexisting, thus to cre
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- Since: 2010-04-06
- Address: No. 186, Lugu Valley Garden Road, High-tech Dev. Zone, Changsha, Hunan, China
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戴杏花
+86-18374838656
info@staherb.cn
+86-18374838656
info@staherb.cn