Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>PROCHLORPERAZINE MALEATE

PROCHLORPERAZINE MALEATE

PROCHLORPERAZINE MALEATE Structure
PROCHLORPERAZINE MALEATE structure
CAS No.
84-02-6
Chemical Name:
PROCHLORPERAZINE MALEATE
Synonyms
PROCHLORPERAZINE DIMALEATE;emetiral;Vertigon;buccastem;pasotomin;nibromina;enedioate(1:2);meterazinmaleate;Einecs 201-511-3;stemetildimaleate
CBNumber:
CB2439552
Molecular Formula:
C28H32ClN3O8S
Molecular Weight:
606.09
MDL Number:
MFCD00069330
MOL File:
84-02-6.mol
MSDS File:
SDS
Last updated:2024-11-19 20:33:22
Request For Quotation

PROCHLORPERAZINE MALEATE Properties

Melting point 1750C
storage temp. 2-8°C
solubility Very slightly soluble in water and in ethanol (96 per cent).
pka pKa 8.1(H2O,t =24±1) (Uncertain)
color White
λmax 313nm(MeOH)(lit.)
Merck 14,7761
Stability Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
FDA UNII I1T8O1JTL6

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
Signal word  Warning
Hazard statements  H302-H336-H361d-H362
Precautionary statements  P202-P260-P263-P264-P301+P312-P308+P313
Hazard Codes  Xn
Risk Statements  20/21/22
Safety Statements  36
WGK Germany  3
RTECS  SO3150000
HS Code  2934302300
Toxicity LD50 in mice (mg/kg): 400 s.c.; 120 i.p.; 90 i.v., 400 orally (Courvoisier)
NFPA 704
0
3 0

PROCHLORPERAZINE MALEATE price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P9178 Prochlorperazine dimaleate salt 84-02-6 5g $68.2 2024-03-01 Buy
Sigma-Aldrich P3200000 Prochlorperazine maleate European Pharmacopoeia (EP) Reference Standard 84-02-6 P3200000 $218 2023-06-20 Buy
Sigma-Aldrich BP638 Prochlorperazine maleate British Pharmacopoeia (BP) Reference Standard 84-02-6 100MG $221 2023-06-20 Buy
Sigma-Aldrich PHR3114 Prochlorperazine Maleate pharmaceutical secondary standard, certified reference material 84-02-6 500MG $175 2022-05-15 Buy
Sigma-Aldrich 1566001 Prochlorperazine maleate United States Pharmacopeia (USP) Reference Standard 84-02-6 200MG $400 2022-05-15 Buy
Product number Packaging Price Buy
P9178 5g $68.2 Buy
P3200000 P3200000 $218 Buy
BP638 100MG $221 Buy
PHR3114 500MG $175 Buy
1566001 200MG $400 Buy

PROCHLORPERAZINE MALEATE Chemical Properties,Uses,Production

Description

Prochlorperazine maleate (84-02-6) inhibits dynamin and clathrin-mediated endocytosis (CME) with an IC50=5.8 μM for CME.1?Increases tumor cell antigen presentation enhancing the efficacy of anti-tumor mAbs.2?A clinically useful antipsychotic agent3?with antimigraine4?and antiemetic activity5.

Chemical Properties

Off-White Powder

Uses

Antiemetic;Dopamine antagonist

Uses

Antiemetic.

brand name

Compazine (GlaxoSmithKline).

General Description

Prochlorperazinemaleate, 2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazinemaleate (Compazine), is in the piperazine subgroupof the phenothiazines, characterized by high-milligramantipsychotic potency, a high prevalence of EPS, and lowsedative and autonomic effects. Prochlorperazine is more potenton a milligram basis than its alkylamino counterpart,chlorpromazine. Because of the high prevalence of EPS, however,it is used mainly for its antiemetic effect, not for its antipsychoticeffect.

Biological Activity

D 2 receptor antagonist. Also interacts with 5-HT 3 and nAChR. Displays antipsychotic, antispasmodic, antiemetic and antinociceptive activity in vivo .

Biochem/physiol Actions

Phenothiazine antipsychotic; D2 dopamine receptor antagonist; antispasmodic

References

References/Citations 1) Daniel?et al.?(2015),?Phenothiazine-derived antipsychotic drugs inhibit dynamin and clathrin-mediated endocytosis; Traffic,?16?635 2) Chew?et al.?(2020),?Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies; Cell,?180?895 3) Hollister?et al.?(1969),?Clinical use of psychotherapeutic drugs: current status;?Clin. Pharmacol. Ther.,?10?170 4) Cook and Newberry (2018),?Emergency Department Use of Intravenous Prochlorperazine for Acute Migraine; Adv. Emerg. Nurs. J.,?40?148 5) Van den Berg?et al.?(1996),?The prophylactic antiemetic efficacy of prochlorperazine and ondansetron in nasal septal surgery: a randomized double-blind comparison; Anaesth. Intensive Care,?24?538

PROCHLORPERAZINE MALEATE Preparation Products And Raw materials

Raw materials

Preparation Products

PROCHLORPERAZINE MALEATE Suppliers

Global( 154)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou FandaChem Co.,Ltd. 		+8615858145714 FandaChem@Gmail.com China 9206 55
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 22783 58
AFINE CHEMICALS LIMITED 		+86-0571-85134551 sales@afinechem.com China 15352 58
Finetech Industry Limited 		+86-27-87465837 +8618971612321 info@finetechnology-ind.com China 9639 58
Dayang Chem (Hangzhou) Co.,Ltd. 		571-88938639 +8617705817739 info@dycnchem.com China 52849 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24727 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38632 58
PT CHEM GROUP LIMITED 		peter68@ptchemgroup.com China 35425 58
Supplier Advantage
Hangzhou FandaChem Co.,Ltd. 		55
TargetMol Chemicals Inc. 		58
Dideu Industries Group Limited 		58
AFINE CHEMICALS LIMITED 		58
Finetech Industry Limited 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
InvivoChem 		58
LEAP CHEM CO., LTD. 		58
TargetMol Chemicals Inc. 		58
PT CHEM GROUP LIMITED 		58

View Lastest Price from PROCHLORPERAZINE MALEATE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Prochlorperazine Maleate pictures 2024-11-19 Prochlorperazine Maleate
84-02-6
 US $38.00-65.00 / mg 99.99% 10g TargetMol Chemicals Inc.
Prochlorperazine Maleate pictures 2024-11-19 Prochlorperazine Maleate
84-02-6
 US $38.00-65.00 / mg 99.99% 10g TargetMol Chemicals Inc.
PROCHLORPERAZINE MALEATE USP/EP/BP pictures 2021-07-24 PROCHLORPERAZINE MALEATE USP/EP/BP
84-02-6
 US $1.10 / g 1g 99.9% 100 Tons min Dideu Industries Group Limited

PROCHLORPERAZINE MALEATE Spectrum

PROCHLORPERAZINE MALEATE(84-02-6)MSPROCHLORPERAZINE MALEATE(84-02-6)1HNMRPROCHLORPERAZINE MALEATE(84-02-6)13CNMRPROCHLORPERAZINE MALEATE(84-02-6)IR1PROCHLORPERAZINE MALEATE(84-02-6)IR2

84-02-6(PROCHLORPERAZINE MALEATE)Related Search:

10-METHYLPHENOTHIAZINE 5-CHLORO-2-(METHYLTHIO)ANILINE 2-AMINO-4'-CHLORODIPHENYL SULFIDE Promazine hydrochloride 3-CHLORODIPHENYLAMINE
Promazine 10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine 1-(3-AMINOPROPYL)PIPERAZINE Chlorpromazine 1-(3-AMINOPROPYL)-4-METHYLPIPERAZINE
2-Chlorophenothiazine PROCHLORPERAZINE MALEATE 1-[3-(DIMETHYLAMINO)PROPYL]PIPERAZINE PIPERAZINE HEXAHYDRATE chlorproethazine
Ammonium hydrogen maleate Prochlorperazine 2-Amino-4-chlorodiphenylsulfide

1of4

2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-phenothiazinmaleate(1:2) buccastem emetiral enedioate(1:2) meterazinmaleate nibromina pasotomin prochloroproazinehydrogenmaleate prochlorperazinebimaleate prochlorperazinehydrogenmaleate prochlorperazinudimaleat stemetildimaleate Prochloroperazine Dimaleate Prochlorperazine Dimaleate Also See: P755800 Vertigon Prochlorpromazine dimaleate 10H-Phenothiazine, 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-, (Z)-2-butenedioate (1:2) Einecs 201-511-3 2-Chloro-10-[3[(4-methyl-1-piperazinyl)propyl]-10H-phenothiazinedimaleate Prochlorperazine Maleate (200 mg) 10H-Phenothiazine, 2-chloro-10-3-(4-methyl-1-piperazinyl)propyl-, (2Z)-2-butenedioate (1:2) PROCHLORPERAZINEMALEATE,USP 2-chloro-10-(3-(4-Methylpiperazin-1-yl)propyl)-10H-phenothiazine PROCHLORPERAZINE DIMALEATE SALT PROCHLORPERAZINE MALEATE 2-chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine,dimaleate 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-10h-phenothiazin(z)-2-but 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazinedimaleate Prochlorperazine Maleate RS Prochlorperazine maleate CRS 2-Chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine Dimaleate PROCHLORPERAZINE MALEATE USP/EP/BP Prochlorperazine dimaleate saltQ: What is Prochlorperazine dimaleate salt Q: What is the CAS Number of Prochlorperazine dimaleate salt Q: What is the storage condition of Prochlorperazine dimaleate salt Q: What are the applications of Prochlorperazine dimaleate salt Prochlorperazine Maleate (1566001) PROCHLORPERAZINE DIMALEATE PROCHLORPERAZINE HCL IP/BP/USP Prochlorperazine dimaleate in methanol C16291000 ProchlorperazinEmaleate 84-02-6 1984-2-6 C20H24ClN3SC4H4O42 C28H32ClN3O8S C24H24ClN3S2C4H4O4 C20H24ClN3S2C4H4O4 Heterocyclic Compounds Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Antagonists Dopaminergics Neurotransmitters