T-3775440 hydrochloride
- CAS No.
- 1422535-52-1
- Chemical Name:
- T-3775440 hydrochloride
- Synonyms
- T-3775440HCl;T 3775440;T3775440;T-3775440 hydrochloride;T3775440 hydrochloride,T-3775440,inhibit,T3775440,T 3775440,Inhibitor,T 3775440 hydrochloride,Histone Demethylase
- CBNumber:
- CB24668572
- Molecular Formula:
- C18H23ClN4O
- Molecular Weight:
- 346.86
- MDL Number:
- MFCD31692337
- MOL File:
- 1422535-52-1.mol
T-3775440 hydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth Carbosynth | BT168491 | T 3775440 hydrochloride | 1422535-52-1 | 5mg | $300 | 2021-12-16 | Buy |
| ChemScene | CS-0023825 | T-3775440hydrochloride 99.13% | 1422535-52-1 | 5mg | $450 | 2021-12-16 | Buy |
| AK Scientific | 7208EA | T-3775440Hydrochloride | 1422535-52-1 | 5mg | $455 | 2021-12-16 | Buy |
| ChemScene | CS-0023825 | T-3775440hydrochloride 99.13% | 1422535-52-1 | 10mg | $750 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BT168491 | T 3775440 hydrochloride | 1422535-52-1 | 25mg | $905 | 2021-12-16 | Buy |
T-3775440 hydrochloride Chemical Properties,Uses,Production
Biological Activity
| Target | Value |
| LSD1 () | 2.1 nM |
Biological Activity
T-3775440 hydrochloride is an irreversible LSD1 inhibitor. It is highly selective for LSD1 relative to other monoamine oxidases with IC50 of 2.1 nM.
in vitro
T-3775440 hydrochloride enhances the transdifferentiation of erythrocytes/megakaryocytes to granule-like monocytes. It disrupts the interaction of LSD1 and GFI1B. AEL (TF-1a, HEL92.1.7) cells and AMKL (CMK11-5, M07e) cells were treated with T-3775440 for 48 hours, which induced cell cycle arrest and apoptosis. In TF-1a and CMK11-5 cells, treatment with T-3775440 increased cells in G1 and sub-G1 phases.
in vivo
T-3775440 inhibits tumor growth in a mouse xenograft model of AML. In mice T-3775440 hydrochloride caused a transient decrease in platelets followed by a large rebound. After a single dose, it had no apparent effect on red blood cell counts. T-3775440 hydrochloride also exerted antitumor activity in AEL (HEL 92.1.7) model and AMKL (CMK11-5) model.
T-3775440 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
T-3775440 hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30239 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| Suzhou Yueheng Pharmaceutical Technology Co., Ltd. | 15962211760 | 2665833871@qq.com | China | 586 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7887 | 56 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9923 | 65 |