Trisodium (2RS,3RS)-2-methylcitrate
- CAS No.
- 117041-96-0
- Chemical Name:
- Trisodium (2RS,3RS)-2-methylcitrate
- Synonyms
- Trisodium 2-methylcitrate;Methylcitric acid trisodium;2-Methylcitric acid trisodium;2-Methylcitrate-d3 Trisodium Salt;Trisodium (2RS,3RS)-2-methylcitrate;2-hydroxy-butane-1,2,3-tricarbonoic acid;TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS;Trisodium 2-methylcitrate, racemic mixture of diastereomers >=85% (mixture of diastereomers, NMR)
- CBNumber:
- CB24739711
- Molecular Formula:
- C7H7O7*3Na
- Molecular Weight:
- 230.15
- MDL Number:
- MFCD16875437
- MOL File:
- 117041-96-0.mol
Trisodium (2RS,3RS)-2-methylcitrate price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 59464 | Trisodium 2-methylcitrate, racemic mixture of diastereomers ≥85% (mixture of diastereomers, NMR) | 117041-96-0 | 10mg | $193 | 2024-03-01 | Buy |
| Sigma-Aldrich | 59464 | Trisodium 2-methylcitrate, racemic mixture of diastereomers ≥85% (mixture of diastereomers, NMR) | 117041-96-0 | 50mg | $770 | 2024-03-01 | Buy |
| ChemScene | CS-0112381 | 2-Methylcitricacid(trisodium) ≥96.0% | 117041-96-0 | 5mg | $480 | 2021-12-16 | Buy |
Trisodium (2RS,3RS)-2-methylcitrate Chemical Properties,Uses,Production
Biological Activity
Trisodium (2RS,3RS)-2-methylcitrate is an endogenous metabolite of the 2-methylcitric acid cycle. It accumulates in methylmalonic acidemia and malonic acidemia and can serve as a metabolic marker. And it significantly inhibits ADP-stimulated and uncoupled respiration in glutamate-supported mitochondria.
in vitro
Trisodium (2RS,3RS)-2-methylcitrate impairs glutamate metabolism and induces permeability transition in brain mitochondria.
2-Methylcitric acid trisodium inhibits glutamate dehydrogenase (GDH) activity at concentrations as low as 0.5 mM.
2-Methylcitric acid trisodium (1 mM, 3 mM; 150 seconds) provokes a significant decrease in mitochondrial membrane potential and induced swelling in Ca 2+ -loaded mitochondria supported by different substrates.
It behaves as a potent inhibitor of glutamate oxidation by inhibiting glutamate dehydrogenase activity and as a permeability transition inducer, disturbing mitochondrial energy homeostasis.
It trisodium does not significantly impair mitochondrial glutamate transport.
2-Methylcitric acid trisodium does not significantly impair glutamate mitochondrial transport in liver mitochondria.
target
| Human Endogenous Metabolite < span> |
Trisodium (2RS,3RS)-2-methylcitrate Preparation Products And Raw materials
Raw materials
Preparation Products
Trisodium (2RS,3RS)-2-methylcitrate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | info@synzest.com | China | 9287 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
| Qingdao Tenglong microwave technology co., LTD. | 0532-83818797 18561885118 | market@tlwb.com.cn | China | 3946 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29778 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 18351873721 | helen.zhang@synzest.com | China | 8298 | 58 |
| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7980 | 58 |
| Shanghai isotope chemical co.,ltd | 021-021-51600108 13062666369 | sales@chinaisotope.com | China | 4274 | 58 |
| Shanghai Saikerui Biotechnology Co. , Ltd. | 021-58000709 15900491054 | info@scrbio.com | China | 9268 | 58 |