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TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS
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- CAS号:
- 117041-96-0
- 英文名:
- Trisodium (2RS,3RS)-2-methylcitrate
- 英文别名:
- Trisodium 2-methylcitrate;Methylcitric acid trisodium;2-Methylcitric acid trisodium;2-Methylcitrate-d3 Trisodium Salt;Trisodium (2RS,3RS)-2-methylcitrate;2-hydroxy-butane-1,2,3-tricarbonoic acid;TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS;Trisodium 2-methylcitrate, racemic mixture of diastereomers >=85% (mixture of diastereomers, NMR)
- 中文名:
- TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS
- 中文别名:
- 2-甲基柠檬酸-D3三钠盐;2-甲基柠檬酸三钠 非标记非对映异构体的混合物 90%+ CP;2-甲基柠檬酸三钠 非对映异构体的混合物 (甲基-D3, 98%) 90%+ CP
- CBNumber:
- CB24739711
- 分子式:
- C7H7O7*3Na
- 分子量:
- 230.15
- MOL File:
- 117041-96-0.mol
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TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS化学性质
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储存条件:
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Store at -20°C
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形态:
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Solid
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颜色:
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White to off-white
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TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS性质、用途与生产工艺
2-Methylcitric acid trisodium (Methylcitric acid trisodium) 是 2- 甲基柠檬酸循环的内源性代谢物。2-Methylcitric acid trisodium 在甲基丙二酸血症和丙二酸酸血症中积累并能作为代谢标志物。2-Methylcitric acid trisodium 对谷氨酸支持的线粒体中 ADP 刺激和不耦合呼吸作用有明显的抑制作用。
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Human Endogenous Metabolite
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2-Methylcitric acid trisodium impairs glutamate metabolism and induces permeability transition in brain mitochondria.
2-Methylcitric acid trisodium inhibits glutamate dehydrogenase (GDH) activity at concentrations as low as 0.5 mM.
2-Methylcitric acid trisodium (1 mM, 3 mM; 150 seconds) provokes a significant decrease in mitochondrial membrane potential and induced swelling in Ca
2+
-loaded mitochondria supported by different substrates.
2-Methylcitric acid trisodium behaves as a potent inhibitor of glutamate oxidation by inhibiting glutamate dehydrogenase activity and as a permeability transition inducer, disturbing mitochondrial energy homeostasis.
2-Methylcitric acid trisodium does not significantly impair mitochondrial glutamate transport.
2-Methylcitric acid trisodium does not significantly impair glutamate mitochondrial transport in liver mitochondria.
TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-113371A | 2-Methylcitric acid trisodium | | 1 mg | 1250元 |
| 2024/04/30 | HY-113371A | TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS
2-Methylcitric acid trisodium | 117041-96-0 | 5mg | 3500元 |
TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS
生产厂家
117041-96-0, TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS 相关搜索:
- 抑制剂
- C7H7O73Na
- 2-甲基柠檬酸-D3三钠盐
- 2-甲基柠檬酸三钠 非对映异构体的混合物 (甲基-D3, 98%) 90%+ CP
- 2-甲基柠檬酸三钠 非标记非对映异构体的混合物 90%+ CP
- 117041-96-0
- Trisodium (2RS,3RS)-2-methylcitrate
- 2-Methylcitrate-d3 Trisodium Salt
- Trisodium 2-methylcitrate
- Trisodium 2-methylcitrate, racemic mixture of diastereomers >=85% (mixture of diastereomers, NMR)
- Methylcitric acid trisodium
- 2-Methylcitric acid trisodium
- 2-hydroxy-butane-1,2,3-tricarbonoic acid
- TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS