TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS CAS#: 117041-96-0

TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS

生物活性靶点体外研究用途与合成方法 MSDS TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS价格(试剂级) 上下游产品信息

中文名称	TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS
中文同义词	2-甲基柠檬酸三钠非标记非对映异构体的混合物 90%+ CP;2-甲基柠檬酸三钠非对映异构体的混合物 (甲基-D3, 98%) 90%+ CP;2-甲基柠檬酸-D3三钠盐
英文名称	Trisodium (2RS,3RS)-2-methylcitrate
英文同义词	TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS;2-hydroxy-butane-1,2,3-tricarbonoic acid;2-Methylcitric acid trisodium;Methylcitric acid trisodium;Trisodium 2-methylcitrate, racemic mixture of diastereomers >=85% (mixture of diastereomers, NMR);Trisodium 2-methylcitrate;2-Methylcitrate-d3 Trisodium Salt;Trisodium (2RS,3RS)-2-methylcitrate
CAS号	117041-96-0
分子式	C7H7O7*3Na
分子量	230.15
EINECS号
相关类别
Mol文件	117041-96-0.mol
结构式

TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS 性质

储存条件	Store at -20°C
形态	固体
颜色	白色至米白色

TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS 用途与合成方法

生物活性

2-Methylcitric acid trisodium (Methylcitric acid trisodium) 是 2- 甲基柠檬酸循环的内源性代谢物。2-Methylcitric acid trisodium 在甲基丙二酸血症和丙二酸酸血症中积累并能作为代谢标志物。2-Methylcitric acid trisodium 对谷氨酸支持的线粒体中 ADP 刺激和不耦合呼吸作用有明显的抑制作用。

靶点

Human Endogenous Metabolite

体外研究

2-Methylcitric acid trisodium impairs glutamate metabolism and induces permeability transition in brain mitochondria.
2-Methylcitric acid trisodium inhibits glutamate dehydrogenase (GDH) activity at concentrations as low as 0.5 mM.
2-Methylcitric acid trisodium (1 mM, 3 mM; 150 seconds) provokes a significant decrease in mitochondrial membrane potential and induced swelling in Ca ²⁺ -loaded mitochondria supported by different substrates.
2-Methylcitric acid trisodium behaves as a potent inhibitor of glutamate oxidation by inhibiting glutamate dehydrogenase activity and as a permeability transition inducer, disturbing mitochondrial energy homeostasis.
2-Methylcitric acid trisodium does not significantly impair mitochondrial glutamate transport.
2-Methylcitric acid trisodium does not significantly impair glutamate mitochondrial transport in liver mitochondria.

安全信息

WGK Germany	3

MSDS信息

TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS 价格(试剂级)

更新日期	产品编号	产品名称	CAS号	包装	价格
2024/08/19	HY-113371A	2-Methylcitric acid trisodium		1 mg	1250元
2024/08/19	HY-113371A	TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS 2-Methylcitric acid trisodium	117041-96-0	5mg	3500元

TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS