ARN14988
- CAS No.
- 1502027-70-4
- Chemical Name:
- ARN14988
- Synonyms
- ARN398;ARN14988;ARN14988,ARN-14988;5-chloro-3-[(hexylamino)carbonyl]-3,6-dihydro-2,6-dioxo-1(2H)-pyrimidinecarboxylicacid,2-methylpropylester;1(2H)-Pyrimidinecarboxylic acid, 5-chloro-3-[(hexylamino)carbonyl]-3,6-dihydro-2,6-dioxo-, 2-methylpropyl ester
- CBNumber:
- CB24814340
- Molecular Formula:
- C16H24ClN3O5
- Molecular Weight:
- 373.83
- MDL Number:
- MOL File:
- 1502027-70-4.mol
ARN14988 price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 24284 | ARN14988 | 1502027-70-4 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 24284 | ARN14988 | 1502027-70-4 | 25mg | $745 | 2024-03-01 | Buy |
| Cayman Chemical | 24284 | ARN14988 | 1502027-70-4 | 5mg | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 24284 | ARN14988 | 1502027-70-4 | 10mg | $341 | 2024-03-01 | Buy |
ARN14988 Chemical Properties,Uses,Production
Description
ARN14988 is a potent inhibitor of acid ceramidase (IC50 = 12.8 nM for the human enzyme). It inhibits acid ceramidase activity and increases levels of C16 dihydro ceramide and C16 ceramide in A375, G361, M14, MeWo, MNT-1, and SK-MEL-28 melanoma cells. ARN14988 also reduces growth of A375 and G361 melanoma cells (EC50s = 41.8 and 67.7 μM, respectively).
Enzyme inhibitor
These sphingolipid-signaling inhibitors (FWARN398 = 307.27 g/mol; FWARN14988 = 373.83 g/mol) target human acid ceramidase, with IC50 values of 7.7 and 12.8 nM, respectively, thereby increasing cellular ceramide levels and decreasing sphingosine 1-phosphate, and synergizing with several antitumor agents. Compared to normal melanocytes, ceramide production is suppressed in melanoma cells, and elevation of ceramide levels enhances the cytotoxic effects of chemotherapeutic drugs on proliferative melanoma cells in culture. ARN398 is unstable, showing a plasma half-life of 1 min and an in vitro half-life of 120 min at pH 4.5. ARN398 is more stable, showing a plasma half-life of 300 min and an in vitro half-life of 140 min at pH 4.5.
ARN14988 Preparation Products And Raw materials
Raw materials
Preparation Products
ARN14988 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1249 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| Nanjing Tengyi Biotechnology Co., Ltd | 025-58851786 17714337195 | sales@tybiochem.com | China | 5595 | 58 |