2,6-Dichlorophenylacetic acid
- CAS No.
- 6575-24-2
- Chemical Name:
- 2,6-Dichlorophenylacetic acid
- Synonyms
- 2-(2,6-DICHLOROPHENYL)ACETIC ACID;TIMTEC-BB SBB003503;2,6-Dichlorophenyla;RARECHEM AL BO 0115;Guanfacine Impurity;Guanfacine Impurity 1;2,6-Dichlorphenylessigsure;6-Dichlorophenylacetic acid;2,6-DICHLOROPHENYLACETIC ACID;2,6-DICHLORO BENZENEACETIC ACID
- CBNumber:
- CB2481995
- Molecular Formula:
- C8H6Cl2O2
- Molecular Weight:
- 205.04
- MDL Number:
- MFCD00004320
- MOL File:
- 6575-24-2.mol
| Melting point | 158-161 °C (lit.) |
|---|---|
| Boiling point | 294.45°C (rough estimate) |
| Density | 1.3806 (rough estimate) |
| refractive index | 1.5490 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 3.80±0.10(Predicted) |
| color | White to Off-White |
| BRN | 1952744 |
| InChI | InChI=1S/C8H6Cl2O2/c9-6-2-1-3-7(10)5(6)4-8(11)12/h1-3H,4H2,(H,11,12) |
| InChIKey | SFAILOOQFZNOAU-UHFFFAOYSA-N |
| SMILES | C1(CC(O)=O)=C(Cl)C=CC=C1Cl |
| CAS DataBase Reference | 6575-24-2(CAS DataBase Reference) |
| FDA UNII | K8G025CX8W |
| NIST Chemistry Reference | 2,6-Dichlorophenylacetic acid(6575-24-2) |
| EPA Substance Registry System | Benzeneacetic acid, 2,6-dichloro- (6575-24-2) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 37/39-26-26/37/39-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29163900 | |||||||||
| NFPA 704 |
|
2,6-Dichlorophenylacetic acid price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 259241 | 2,6-Dichlorophenylacetic acid 97% | 6575-24-2 | 25g | $39.2 | 2023-06-20 | Buy |
| Sigma-Aldrich | 259241 | 2,6-Dichlorophenylacetic acid 97% | 6575-24-2 | 100g | $149 | 2023-06-20 | Buy |
| TCI Chemical | D1897 | 2,6-Dichlorophenylacetic Acid >96.0%(T) | 6575-24-2 | 25g | $133 | 2024-03-01 | Buy |
| Alfa Aesar | B21354 | 2,6-Dichlorophenylacetic acid, 98% | 6575-24-2 | 5g | $22.65 | 2024-03-01 | Buy |
| Alfa Aesar | B21354 | 2,6-Dichlorophenylacetic acid, 98% | 6575-24-2 | 25g | $59.65 | 2024-03-01 | Buy |
2,6-Dichlorophenylacetic acid Chemical Properties,Uses,Production
Chemical Properties
white crystalline powder
Uses
2,6-Dichlorophenylacetic acid is an inhibitor of isopenicillin N synthase (IPNS) and acyl-CoA: 6-APA acyltransferase. 2,6-Dichlorophenylacetic acid is also part of a group of phenylacetate derivatives that have cytostatic activity against tumour cells.
Preparation
The preparation of the 2, 6-dichlorophenylacetic acid:
the method comprises the following steps: 2, 6-dichlorotoluene is used as a raw material, and is catalyzed by a complex catalyst formed by transition metal and a ligand (wherein, a transition metal catalyst precursor is preferably palladium chloride, an oxidant is preferably TBP (tert-butyl peroxy ether), and a ligand is preferably Xantphos (4, 5-bis (diphenylphosphino) -9, 9-dimethyl xanthene)) in the presence of an alcohol and a catalyst and an oxidant to obtain 2, 6-dichlorophenylacetic acid, and the ethyl 2, 6-dichlorophenylacetate is prepared by hydrolysis and acidification, wherein the total yield is 68.4%. See patent document US2013303798, the reaction procedure is described as synthetic route 1.
In the above synthetic route 1, the preparation process of the intermediate ethyl 2, 6-dichlorophenylacetate requires the use of carbon monoxide for high-temperature and high-pressure reaction, and has poor operation safety, high equipment requirement, high cost, and is not favorable for cost reduction and green production of 2, 6-dichlorophenylacetic acid.
Purification Methods
Crystallise the acid from aqueous EtOH. [Beilstein 9 III 2272.]
2,6-Dichlorophenylacetic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5868 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18137 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29730 | 60 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2957 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6383 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 | info@edengenechem.com | China | 2176 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
View Lastest Price from 2,6-Dichlorophenylacetic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-27 | 2,6-Dichlorophenylacetic acid
6575-24-2
|
US $10.00 / kg | 1kg | 99% | 20 ton | Hebei Zhuanglai Chemical Trading Co Ltd | |
 |
2025-04-15 | 2,6-Dichlorophenylacetic acid
6575-24-2
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2024-10-11 | 2,6-Dichlorophenylacetic acid
6575-24-2
|
US $9.00 / KG | 1KG | 99.9 | 1 ton | Hebei Chuanghai Biotechnology Co,.LTD |
-
- 2,6-Dichlorophenylacetic acid
6575-24-2
- US $10.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co Ltd
-
- 2,6-Dichlorophenylacetic acid
6575-24-2
- US $0.00-0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 2,6-Dichlorophenylacetic acid
6575-24-2
- US $9.00 / KG
- 99.9
- Hebei Chuanghai Biotechnology Co,.LTD
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