2,6-Dichlorophenylacetic acid
- CAS No.
- 6575-24-2
- Chemical Name:
- 2,6-Dichlorophenylacetic acid
- Synonyms
- 2-(2,6-DICHLOROPHENYL)ACETIC ACID;TIMTEC-BB SBB003503;2,6-Dichlorophenyla;RARECHEM AL BO 0115;Guanfacine Impurity;Guanfacine Impurity 1;2,6-Dichlorphenylessigsure;6-Dichlorophenylacetic acid;2,6-DICHLOROPHENYLACETIC ACID;2,6-DICHLORO BENZENEACETIC ACID
- CBNumber:
- CB2481995
- Molecular Formula:
- C8H6Cl2O2
- Molecular Weight:
- 205.04
- MDL Number:
- MFCD00004320
- MOL File:
- 6575-24-2.mol
Melting point | 158-161 °C (lit.) |
---|---|
Boiling point | 294.45°C (rough estimate) |
Density | 1.3806 (rough estimate) |
refractive index | 1.5490 (estimate) |
storage temp. | Sealed in dry,Room Temperature |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 3.80±0.10(Predicted) |
color | White to Off-White |
BRN | 1952744 |
InChI | InChI=1S/C8H6Cl2O2/c9-6-2-1-3-7(10)5(6)4-8(11)12/h1-3H,4H2,(H,11,12) |
InChIKey | SFAILOOQFZNOAU-UHFFFAOYSA-N |
SMILES | C1(CC(O)=O)=C(Cl)C=CC=C1Cl |
CAS DataBase Reference | 6575-24-2(CAS DataBase Reference) |
FDA UNII | K8G025CX8W |
NIST Chemistry Reference | 2,6-Dichlorophenylacetic acid(6575-24-2) |
EPA Substance Registry System | Benzeneacetic acid, 2,6-dichloro- (6575-24-2) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319 | |||||||||
Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 37/39-26-26/37/39-36 | |||||||||
WGK Germany | 3 | |||||||||
Hazard Note | Irritant | |||||||||
HS Code | 29163900 | |||||||||
NFPA 704 |
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2,6-Dichlorophenylacetic acid price More Price(33)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 259241 | 2,6-Dichlorophenylacetic acid 97% | 6575-24-2 | 25g | $39.2 | 2023-06-20 | Buy |
Sigma-Aldrich | 259241 | 2,6-Dichlorophenylacetic acid 97% | 6575-24-2 | 100g | $149 | 2023-06-20 | Buy |
TCI Chemical | D1897 | 2,6-Dichlorophenylacetic Acid >96.0%(T) | 6575-24-2 | 25g | $133 | 2024-03-01 | Buy |
Alfa Aesar | B21354 | 2,6-Dichlorophenylacetic acid, 98% | 6575-24-2 | 5g | $22.65 | 2024-03-01 | Buy |
Alfa Aesar | B21354 | 2,6-Dichlorophenylacetic acid, 98% | 6575-24-2 | 25g | $59.65 | 2024-03-01 | Buy |
2,6-Dichlorophenylacetic acid Chemical Properties,Uses,Production
Chemical Properties
white crystalline powder
Uses
2,6-Dichlorophenylacetic acid is an inhibitor of isopenicillin N synthase (IPNS) and acyl-CoA: 6-APA acyltransferase. 2,6-Dichlorophenylacetic acid is also part of a group of phenylacetate derivatives that have cytostatic activity against tumour cells.
Preparation
The preparation of the 2, 6-dichlorophenylacetic acid:
the method comprises the following steps: 2, 6-dichlorotoluene is used as a raw material, and is catalyzed by a complex catalyst formed by transition metal and a ligand (wherein, a transition metal catalyst precursor is preferably palladium chloride, an oxidant is preferably TBP (tert-butyl peroxy ether), and a ligand is preferably Xantphos (4, 5-bis (diphenylphosphino) -9, 9-dimethyl xanthene)) in the presence of an alcohol and a catalyst and an oxidant to obtain 2, 6-dichlorophenylacetic acid, and the ethyl 2, 6-dichlorophenylacetate is prepared by hydrolysis and acidification, wherein the total yield is 68.4%. See patent document US2013303798, the reaction procedure is described as synthetic route 1.
In the above synthetic route 1, the preparation process of the intermediate ethyl 2, 6-dichlorophenylacetate requires the use of carbon monoxide for high-temperature and high-pressure reaction, and has poor operation safety, high equipment requirement, high cost, and is not favorable for cost reduction and green production of 2, 6-dichlorophenylacetic acid.
Purification Methods
Crystallise the acid from aqueous EtOH. [Beilstein 9 III 2272.]
2,6-Dichlorophenylacetic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 | daisy@crovellbio.com | China | 5828 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2967 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 | info@edengenechem.com | China | 2169 | 58 |
Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10828 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
View Lastest Price from 2,6-Dichlorophenylacetic acid manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2024-08-15 | 2,6-Dichlorophenylacetic acid
6575-24-2
|
US $9.00 / KG | 1KG | 99.9 | 1 ton | Hebei Guanlang Biotechnology Co,.LTD | |
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2023-11-13 | 2,6-Dichlorophenylacetic acid
6575-24-2
|
US $614.40 / Kg/Drum | 1Kg/Bag | 98% | 10tons | Wuhan Boye Science And Technology Development Co., Ltd. | |
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2023-09-06 | 2,6-Dichlorophenylacetic acid
6575-24-2
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Guanlang Biotechnology Co., Ltd. |
-
- 2,6-Dichlorophenylacetic acid
6575-24-2
- US $9.00 / KG
- 99.9
- Hebei Guanlang Biotechnology Co,.LTD
-
- 2,6-Dichlorophenylacetic acid
6575-24-2
- US $614.40 / Kg/Drum
- 98%
- Wuhan Boye Science And Technology Development Co., Ltd.
-
- 2,6-Dichlorophenylacetic acid
6575-24-2
- US $0.00-0.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.
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