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IC 261

CAS No.
186611-52-9
Chemical Name:
IC 261
Synonyms
CS-1551;IC261, >98%;SU-5607 IC 261;IC-261(SU-5607);IC261;SU5607;IC 261;SU 5607;IC261 - CAS 186611-52-9 - Calbiochem;3-(2,4,6-Ttrimethoxybenzylidene)indolin-2-one;(E)-3-(2,4,6-trimethoxybenzylidene)indolin-2-one;IC261,Inhibitor,Apoptosis,IC-261,inhibit,IC 261,Casein Kinase;1,3-Dihydro-3-[(2,4,6-triMethoxyphenyl)Methylene]-2H-indol-2-one, SU5607
CBNumber:
CB2503626
Molecular Formula:
C18H17NO4
Molecular Weight:
311.335
MDL Number:
MFCD00118156
MOL File:
186611-52-9.mol
MSDS File:
SDS
Last updated:2024-11-19 23:02:33

IC 261 Properties

Melting point 214 °C
storage temp. protect from light
solubility DMSO: 18 mg/mL soluble
form solid
color yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  3
HS Code  2933.79.8500

IC 261 price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich I0658 IC 261 ≥98% (HPLC) 186611-52-9 5mg $81.6 2024-03-01 Buy
Sigma-Aldrich 400090 IC261 186611-52-9 5mg $216 2024-03-01 Buy
TCI Chemical I1077 IC 261 >98.0%(HPLC) 186611-52-9 10mg $132 2024-03-01 Buy
TCI Chemical I1077 IC 261 >98.0%(HPLC) 186611-52-9 50mg $460 2024-03-01 Buy
Cayman Chemical 17260 IC 261 ≥95% 186611-52-9 1mg $32 2024-03-01 Buy
Product number Packaging Price Buy
I0658 5mg $81.6 Buy
400090 5mg $216 Buy
I1077 10mg $132 Buy
I1077 50mg $460 Buy
17260 1mg $32 Buy

IC 261 Chemical Properties,Uses,Production

General Description

A cell-permeable, reversible, potent and selective inhibitor of Casein Kinase (CK1) that inhibits the CK1δ (IC50 = 0.7-1.3 μM) and CK1ε (IC50 = 0.6-1.4 μM) isozymes. Also inhibits CK1α1 at much higher concentrations (IC50 = 11-21 μM). The inhibition is competitive with respect to ATP. Has only a trivial effect on p34cdc2 and p55fyn (IC50s >100 μM). Blocks the phosphorylation of p53 by CK1δ and CK1ε, thereby modulating p53′s effect on the cell cycle. At low micromolar concentrations, IC261 inhibits cytokinesis causing a transient mitotic arrest.

Biological Activity

ic261 is a novel inhibitor of ck1.the p53-targeted kinases casein kinase 1delta (ck1delta) and casein kinase 1epsilon (ck1epsilon) have been reported to be involved in regulating dna repair and chromosomal segregation.

Biochem/physiol Actions

Cell permeable: yes

in vitro

previoius study found that ic261 could trigger the mitotic checkpoint control. at low micromolar concentrations, ic261 inhibited cytokinesis leading to a transient mitotic arrest. cells with active p53 arrested in the postmitotic g1 phase by blockage of entry into the s phase. cells containing non-functional p53 had postmitotic replication developing an 8n dna content. the increase of dna content was accompanied by a high amount of micronucleated and apoptotic cells. immunfluorescence images also showed that ic261 could result in centrosome amplification causing multipolar mitosis at low concentrations [1].

in vivo

animal study indicated that intrathecal injection of ic261 (0.1-1 nmol) could dose-dependently decrease mechanical allodynia and thermal hyperalgesia that were induced by carrageenan or cfa. in addition, bath-application of ic261 (1 μm) showed only marginal effects on spontaneous excitatory postsynaptic currents recorded in the substantia gelatinosa neurons of control mice. however, ic261 could decrease the frequency of sepscs in both inflammatory pain models [2].

IC 50

16 μm

storage

Store at -20°C

References

1]. behrend l, et al. ic261, a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects. oncogene. 2000 nov 9;19(47):5303-5313.
[2] kurihara t,et al. alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (ck1) inhibitors. mol pain.2014 mar 10;10:17.

59-48-3
830-79-5
186611-52-9
Synthesis of IC 261 from Oxindole and 2,4,6-Trimethoxybenzaldehyde

IC 261 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 90)Suppliers
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ATK CHEMICAL COMPANY LIMITED
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Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2922 55

View Lastest Price from IC 261 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
IC261 pictures 2024-11-19 IC261
186611-52-9
US $64.00-189.00 / mg 99.86% 10g TargetMol Chemicals Inc.
IC 261 pictures 2019-12-23 IC 261
186611-52-9
US $1.00 / ASSAYS 100ASSAYS 99% G/KG/T Career Henan Chemical Co
  • IC261 pictures
  • IC261
    186611-52-9
  • US $64.00-189.00 / mg
  • 99.86%
  • TargetMol Chemicals Inc.
  • IC 261 pictures
  • IC 261
    186611-52-9
  • US $1.00 / ASSAYS
  • 99%
  • Career Henan Chemical Co
SU5607, 1,3-Dihydro-3-[(2,4,6-trimethoxyphenyl)methylene]-2H-indol-2-one 1,3-Dihydro-3-[(2,4,6-triMethoxyphenyl)Methylene]-2H-indol-2-one, SU5607 SU-5607 IC 261 (E)-3-(2,4,6-trimethoxybenzylidene)indolin-2-one IC261, >98% IC-261(SU-5607) IC261 - CAS 186611-52-9 - Calbiochem IC261;SU5607;IC 261;SU 5607 CS-1551 3-(2,4,6-Ttrimethoxybenzylidene)indolin-2-one IC261,Inhibitor,Apoptosis,IC-261,inhibit,IC 261,Casein Kinase 186611-52-9 Inhibitors