CS-1551;IC261, >98%;IC261 (IC-261;SU-5607 IC 261;IC-261(SU-5607);IC261, 10 mM in DMSO;IC261;SU5607;IC 261;SU 5607;IC261 - CAS 186611-52-9 - Calbiochem;IC 261, CK1delta and CK1epsilon inhibitor;3-(2,4,6-Ttrimethoxybenzylidene)indolin-2-one
눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
IC 261 C화학적 특성, 용도, 생산
일반 설명
A cell-permeable, reversible, potent and selective inhibitor of Casein Kinase (CK1) that inhibits the CK1δ (IC50 = 0.7-1.3 μM) and CK1ε (IC50 = 0.6-1.4 μM) isozymes. Also inhibits CK1α1 at much higher concentrations (IC50 = 11-21 μM). The inhibition is competitive with respect to ATP. Has only a trivial effect on p34cdc2 and p55fyn (IC50s >100 μM). Blocks the phosphorylation of p53 by CK1δ and CK1ε, thereby modulating p53′s effect on the cell cycle. At low micromolar concentrations, IC261 inhibits cytokinesis causing a transient mitotic arrest.
