ChemicalBook >> CAS DataBase List >>CXCR2-IN-68
CXCR2-IN-68
- CAS No.
- 1838123-21-9
- Chemical Name:
- CXCR2-IN-68
- Synonyms
- CXCR2-IN-2;CXCR2-IN-68;CXCR2IN2,CXCR2 IN 2,CXCR-2-IN-2;Urea, N-[4-chloro-2-hydroxy-3-[[(3S)-tetrahydro-3-methyl-3-furanyl]sulfonyl]phenyl]-N'-[(1R)-2-methyl-2-cyclopenten-1-yl]-
- CBNumber:
- CB25867417
- Molecular Formula:
- C18H23ClN2O5S
- Molecular Weight:
- 414.9
- MDL Number:
- MFCD33548813
- MOL File:
- 1838123-21-9.mol
Last updated:2024-07-02 08:55:04
CXCR2-IN-68 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0079459 | CXCR2-IN-2 99.35% | 1838123-21-9 | 5mg | $400 | 2021-12-16 | Buy |
| ChemScene | CS-0079459 | CXCR2-IN-2 99.35% | 1838123-21-9 | 10mg | $680 | 2021-12-16 | Buy |
| ChemScene | CS-0079459 | CXCR2-IN-2 99.35% | 1838123-21-9 | 25mg | $1350 | 2021-12-16 | Buy |
| ChemScene | CS-0079459 | CXCR2-IN-2 99.35% | 1838123-21-9 | 50mg | $2200 | 2021-12-16 | Buy |
| ChemScene | CS-0079459 | CXCR2-IN-2 99.35% | 1838123-21-9 | 100mg | $3400 | 2021-12-16 | Buy |
CXCR2-IN-68 Chemical Properties,Uses,Production
Biological Activity
CXCR2-IN-2 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist (IC50=5.2 nM/1 nM in β-arrestin assay/CXCR2 Tango assay, respectively). CXCR2-IN-2 displays ~730-fold selectivity over CXCR1 and >1900-fold selectivity over all other chemokine receptors. CXCR2-IN-2 inhibits human whole blood Gro-α induced CD11b expression with an IC50 of 0.04 μM[1]. CXCR2-IN-2 (compound 68) (1-10 mg/kg; p.o.; twice daily for 3 days) dose-dependently reduces neutrophil infiltration in vivo in rat and mouse air pouch models[1].
References
[1]. Lu H, et al. Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists. J Med Chem. 2018;61(6):2518-2532.
CXCR2-IN-68 Preparation Products And Raw materials
Raw materials
Preparation Products
CXCR2-IN-68 Suppliers
Global( 5)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23963 | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 021-59167510 18117107507 | vip@med-life.cn | China | 5012 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 12007 | 58 |
| Supplier | Advantage |
|---|---|
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 58 |
| Aladdin Scientific | 58 |
| TargetMol Chemicals Inc. | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 58 |
CXCR2-IN-68
Urea, N-[4-chloro-2-hydroxy-3-[[(3S)-tetrahydro-3-methyl-3-furanyl]sulfonyl]phenyl]-N'-[(1R)-2-methyl-2-cyclopenten-1-yl]-
CXCR2-IN-2
CXCR2IN2,CXCR2 IN 2,CXCR-2-IN-2
1838123-21-9