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AS-2077715

AS-2077715 Structure
AS-2077715 structure
CAS No.
1637356-98-9
Chemical Name:
AS-2077715
Synonyms
AS-2077715;3-[6-(3,5-dimethylheptyl)tetrahydro-2H-pyran-2-yl]-4-hydroxy-1-methyl-5-(2,3,4,5-tetrahydroxycyclopentyl)-2(1H)-pyridinone;2(1H)-Pyridinone, 3-[6-(3,5-dimethylheptyl)tetrahydro-2H-pyran-2-yl]-4-hydroxy-1-methyl-5-(2,3,4,5-tetrahydroxycyclopentyl)-
CBNumber:
CB26197872
Molecular Formula:
C25H41NO7
Molecular Weight:
467.6
MDL Number:
MOL File:
1637356-98-9.mol
Last updated:2023-05-21 10:59:17
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AS-2077715 Properties

Boiling point 622.9±55.0 °C(Predicted)
Density 1.274±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
form A solid
pka 4.50±1.00(Predicted)

AS-2077715 Chemical Properties,Uses,Production

Biological Activity

AS-2077715 is a fungal metabolite and an inhibitor of fungal mitochondrial complex III (cytochrome bc1; IC50 = 80 ng/ml for T. mentagrophytes complex III).1 It is selective for fungal over mammalian complex III (IC50s = 480 and 860 ng/ml for murine EL-4 cell and human Jurkat cell complex III, respectively). AS-2077715 inhibits ATP production in (IC50 = 0.33 μg/ml) and is fungicidal against T. mentagrophytes when used at concentrations of 1 and 10 μg/ml. In vivo, AS-2077715 (10 and 20 mg/kg) reduces the number of foot pad skin colony forming units (CFUs) in a guinea pig model of T. mentagrophytes infection.2

References

1.Ohsumi, K., Watanabe, M., and Fujie, A.AS2077715 Is a selective inhibitor of fungal mitochondrial cytochrome Bc? complexJ. Antibiot. (Tokyo)67(10)713-716(2014) 2.Ohsumi, K., Murai, H., Nakamura, I., et al.Therapeutic efficacy of AS2077715 against experimental tinea pedis in guinea pigs in comparison with terbinafineJ. Antibiot. (Tokyo)67(10)717-719(2014)

AS-2077715 Preparation Products And Raw materials

Raw materials

Preparation Products

AS-2077715 Suppliers

Global( 4)Suppliers
Supplier Tel Email Country ProdList Advantage
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Shanghai Yiyan Biotechnology Co. , Ltd. 021-69985186 13611928337 3427709316@qq.com China 7984 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8739 58
Supplier Advantage
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Shanghai Yiyan Biotechnology Co. , Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
AS-2077715 2(1H)-Pyridinone, 3-[6-(3,5-dimethylheptyl)tetrahydro-2H-pyran-2-yl]-4-hydroxy-1-methyl-5-(2,3,4,5-tetrahydroxycyclopentyl)- 3-[6-(3,5-dimethylheptyl)tetrahydro-2H-pyran-2-yl]-4-hydroxy-1-methyl-5-(2,3,4,5-tetrahydroxycyclopentyl)-2(1H)-pyridinone 1637356-98-9