METHOTREXATE HYDRATE
- CAS No.
- 133073-73-1
- Chemical Name:
- METHOTREXATE HYDRATE
- Synonyms
- L-MTX;MTX HYDRATE;(+)Amethopterin;Antifolan hydrate;METHOTREXATE, VETEC;METHOTREXATE HYDRATE;Methotrexate xhydrate;L-AMETHOPTERIN HYDRATE;Methotrexate trihydrate;(+)AMETHOPTERINE HYDRATE
- CBNumber:
- CB2704227
- Molecular Formula:
- C20H24N8O6
- Molecular Weight:
- 472.46
- MDL Number:
- MFCD00150847
- MOL File:
- 133073-73-1.mol
| Melting point | 195 °C |
|---|---|
| storage temp. | -20°C |
| solubility | H2O: insoluble |
| form | powder |
| color | yellow |
| optical activity | [α]/D +21.0±2.0° |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| InChIKey | FBOZXECLQNJBKD-ZDUSSCGKSA-N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319-H360FD | |||||||||
| Precautionary statements | P201-P202-P264-P301+P310-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 61-25-36/38-46 | |||||||||
| Safety Statements | 53-26-36/37-45-36 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | MA1225000 | |||||||||
| HS Code | 29339980 | |||||||||
| NFPA 704 |
|
METHOTREXATE HYDRATE price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 06563 | Methotrexate hydrate ≥99.0% (sum of enantiomers, HPLC) | 133073-73-1 | 5mg | $27.9 | 2024-03-01 | Buy |
| Sigma-Aldrich | 06563 | Methotrexate hydrate ≥99.0% (sum of enantiomers, HPLC) | 133073-73-1 | 25mg | $77.6 | 2024-03-01 | Buy |
| TCI Chemical | M1664 | Methotrexate Hydrate >98.0%(HPLC)(T) | 133073-73-1 | 1g | $171 | 2024-03-01 | Buy |
| TCI Chemical | M1664 | Methotrexate Hydrate >98.0%(HPLC)(T) | 133073-73-1 | 5g | $624 | 2024-03-01 | Buy |
| Cayman Chemical | 13960 | Methotrexate (hydrate) | 133073-73-1 | 100mg | $45 | 2024-03-01 | Buy |
METHOTREXATE HYDRATE Chemical Properties,Uses,Production
Description
Methotrexate (MTX) is similar in structure to folic acid and aminopterin . It acts by inhibiting the metabolism of folic acid and blocking key enzymes in the synthesis of purines and pyrimidines required for cell proliferation. MTX is known to induce adenosine release, which mediates many of its anti-inflammatory effects, including the reduction of proinflammatory cytokines. Formulations containing MTX have been used as immunosuppressants, in the treatment of cancer, autoimmune disease, ectopic pregnancy, and for the induction of medical abortions. MTX formulations have been considered the gold standard of disease-modifying antirheumatic drug (DMARD) therapy to treat both the immune-inflammatory and joint destructive processes of rheumatoid arthritis.
Chemical Properties
yellow to orange crystalline powder
Uses
Methotrexate hydrate has been used:
- as a dihydrofolate (DHFR)?inhibitor in sphere forming assay culture
- as a component of dulbecco′ modified Eagle′s medium (DMEM) for selection of transfected cells
- in viability and co-culture assays
Uses
Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.
Definition
ChEBI: Methotrexate hydrate is a member of folic acids.
Biochem/physiol Actions
Methotrexate is an allosteric inhibititor of dihydrofolate reductase (DHFR), the enzyme that catalyzes the conversion of dihydrofolate to tetrahydrofolate. Since tetrahydrolfolate is required for purine and pyrimidine synthesis, methotrexate treatment results in the inhibition of DNA and RNA synthesis.
References
Wessels et al. (2008), Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis; Rheumatology (Oxford), 47 249 Allegra et al. (1987), Evidence for direct inhibition of de novo purine synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate; Biol. Chem., 262 13520 Chu et al. (1990), Mechanism of thymidylate synthase inhibition by methotrexate in human neoplastic cell lines and normal human myeloid progenitor cells; Biol. Chem., 265 8470 Gerards et al. (2003), Inhibition of cytokine production by methotrexate. Studies in healthy volunteers and patients with rheumatoid arthritis; Rheumatology (Oxford), 42 1189 Friedman and Cronstein (2019), Methotrexate mechanism in treatment of rheumatoid arthritis; Joint Bone Spine, 86 301 Smolen and Steiner (2003), Therapeutic strategies for rheumatoid arthritis; Rev. Drug Discov., 2 473
METHOTREXATE HYDRATE Preparation Products And Raw materials
Raw materials
Preparation Products
METHOTREXATE HYDRATE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29880 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 11817 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22784 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49978 | 58 |
View Lastest Price from METHOTREXATE HYDRATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-02 | METHOTREXATE HYDRATE USP/EP/BP
133073-73-1
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-05-03 | L(+)-AMethopterin hydrate
133073-73-1
|
US $0.00-0.00 / Kg | 1KG | 99.0% | 800 ton | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-06 | METHOTREXATE HYDRATE
133073-73-1
|
US $10.00 / KG/Tin | 1KG | 99% | 100 | Career Henan Chemical Co |
-
- METHOTREXATE HYDRATE USP/EP/BP
133073-73-1
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- L(+)-AMethopterin hydrate
133073-73-1
- US $0.00-0.00 / Kg
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- METHOTREXATE HYDRATE
133073-73-1
- US $10.00 / KG/Tin
- 99%
- Career Henan Chemical Co
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