METHOTREXATE HYDRATE

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Products Intro: Product Name:METHOTREXATE HYDRATE
CAS:133073-73-1
Purity:99% Package:1KG/Tin;10USD
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Products Intro: Product Name:METHOTREXATE HYDRATE
CAS:133073-73-1
Purity:0.98 Package:1kg,2kg,5kg,10kg,25kg
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Products Intro: Product Name:METHOTREXATE HYDRATE
CAS:133073-73-1
Purity:95% Min. Package:100g; 500g; 1kg; 25kg;bulk package
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Products Intro: Product Name:Methotrexate
CAS:133073-73-1
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Products Intro: Product Name:METHOTREXATE HYDRATE
CAS:133073-73-1
Purity:99.9% Package:1g;1.1USD Remarks:FDA GMP CEP Approved Manufacturer

METHOTREXATE HYDRATE manufacturers

  • METHOTREXATE HYDRATE
  • METHOTREXATE HYDRATE pictures
  • $10.00 / 1KG/Tin
  • 2019-07-06
  • CAS:133073-73-1
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 100
METHOTREXATE HYDRATE Basic information
Product Name:METHOTREXATE HYDRATE
Synonyms:l-4-amino-n10-methylpteroylglutamic acid;4-Amino-10-methylfolic acid hydrate, Antifolan hydrate, Methotrexate hydrate, Methylaminopterin hydrate, MTX hydrate, L-4-Amino-N10-methylpteroylglutamic acid hydrate;4-Amino-10-methylfolic acid hydrate, L-Amethopterin hydrate, Antifolan hydrate, Methylaminopterin hydrate, MTX hydrate, L-4-Amino-N10-methylpteroylglutamic acid hydrate;Methotrexate hydrate,4-Amino-10-methylfolic acid hydrate, L-4-Amino-N10-methylpteroylglutamic acid hydrate, L-Amethopterin hydrate, Antifolan hydrate, MTX hydrate, Methylaminopterin hydrate;Methotrexate hydrate,4-Amino-10-methylfolic acid hydrate, L-4-Amino-N10-methylpteroylglutamic acid hydrate, L-Amethopterin hydrate, Antifolan hydrate, MTX hydrate, Methotrexate hydrate, Methylaminopte;L(+)-AMethopterin hydrate, 99% 100MG;Methotrexate hydrate 4-AMino-10-Methylfolic acid hydrate;N-[4-[[(2,4-diaMino-6-pteridinyl)Methyl]MethylaMino]ben
CAS:133073-73-1
MF:C20H24N8O6
MW:472.46
EINECS:625-397-3
Product Categories:
Mol File:133073-73-1.mol
METHOTREXATE HYDRATE Structure
METHOTREXATE HYDRATE Chemical Properties
Melting point 195 °C
storage temp. -20°C
solubility H2O: insoluble
form powder
color yellow
optical activity[α]/D +21.0±2.0°
Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKeyFBOZXECLQNJBKD-ZDUSSCGKSA-N
Safety Information
Hazard Codes T
Risk Statements 61-25-36/38-46
Safety Statements 53-26-36/37-45-36
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS MA1225000
HS Code 29339980
MSDS Information
ProviderLanguage
SigmaAldrich English
METHOTREXATE HYDRATE Usage And Synthesis
DescriptionMethotrexate (MTX) is similar in structure to folic acid and aminopterin . It acts by inhibiting the metabolism of folic acid and blocking key enzymes in the synthesis of purines and pyrimidines required for cell proliferation. MTX is known to induce adenosine release, which mediates many of its anti-inflammatory effects, including the reduction of proinflammatory cytokines. Formulations containing MTX have been used as immunosuppressants, in the treatment of cancer, autoimmune disease, ectopic pregnancy, and for the induction of medical abortions. MTX formulations have been considered the gold standard of disease-modifying antirheumatic drug (DMARD) therapy to treat both the immune-inflammatory and joint destructive processes of rheumatoid arthritis.
Chemical Propertiesyellow to orange crystalline powder
UsesMethotrexate hydrate has been used:
  • as a dihydrofolate (DHFR)?inhibitor in sphere forming assay culture
  • as a component of dulbecco′ modified Eagle′s medium (DMEM) for selection of transfected cells
  • in viability and co-culture assays

UsesPotent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.
DefinitionChEBI: Methotrexate hydrate is a member of folic acids.
Biochem/physiol ActionsMethotrexate is an allosteric inhibititor of dihydrofolate reductase (DHFR), the enzyme that catalyzes the conversion of dihydrofolate to tetrahydrofolate. Since tetrahydrolfolate is required for purine and pyrimidine synthesis, methotrexate treatment results in the inhibition of DNA and RNA synthesis.
ReferencesWessels et al. (2008), Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis; Rheumatology (Oxford), 47 249 Allegra et al. (1987), Evidence for direct inhibition of de novo purine synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate; Biol. Chem., 262 13520 Chu et al. (1990), Mechanism of thymidylate synthase inhibition by methotrexate in human neoplastic cell lines and normal human myeloid progenitor cells; Biol. Chem., 265 8470 Gerards et al. (2003), Inhibition of cytokine production by methotrexate. Studies in healthy volunteers and patients with rheumatoid arthritis; Rheumatology (Oxford), 42 1189 Friedman and Cronstein (2019), Methotrexate mechanism in treatment of rheumatoid arthritis; Joint Bone Spine, 86 301 Smolen and Steiner (2003), Therapeutic strategies for rheumatoid arthritis; Rev. Drug Discov., 2 473
METHOTREXATE HYDRATE Preparation Products And Raw materials
Tag:METHOTREXATE HYDRATE(133073-73-1) Related Product Information
METHOTREXATE HYDRATE CELL/INSECT CELL*CU LTURE TESTE SU 4312 Folic acid (+/-)AMETHOPTERIN Methotrexate sodium METHOTREXATE HYDRATE 7-CYANOMETHOTREXATE DIMETHYL ESTER METHOTREXATE DIMETHYL ESTER Dichloromethotrexate 7-HYDROXY METHOTREXATE METHOTREXATE-METHYL-D3, DIMETHYL ESTER METHOTREXATE-D3 METHOTREXATE SODIUM SALT, [3',5',7'-3H] 7-HYDROXY METHOXTREXATE-D3 FLUORESCEIN METHOTREXATE, TRIAMMONIUM SALT METHOTREXATE-[3',5',7-3H(N)] DISODIUM SALT [3',5',7-3H]METHOTREXATE, SODIUM SALT METHOTREXATE DISODIUM SALT, [L-GLUTAMIC (1-14C)]