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Brompheniramine hydrogen maleate

CAS No.
980-71-2
Chemical Name:
Brompheniramine hydrogen maleate
Synonyms
dimegan;dimotane;dimetane;ilvinmaleate;Rolabromophen;dimetanemaleate;Brompheniramine MaL;BroMpheniraMine hydr;parabromdylaminemaleate;BROMPHENIRAMINE MALEATE
CBNumber:
CB2736194
Molecular Formula:
C20H23BrN2O4
Molecular Weight:
435.31
MDL Number:
MFCD00057367
MOL File:
980-71-2.mol
Last updated:2024-12-18 14:07:02

Brompheniramine hydrogen maleate Properties

Melting point 134-135°C
Flash point 9℃
storage temp. Inert atmosphere,Room Temperature
solubility Soluble in water, freely soluble in ethanol (96 per cent), in methanol and in methylene chloride.
form Solid
color White to Off-White
λmax 261nm(lit.)
Merck 14,1443
Stability Hygroscopic
InChIKey SRGKFVAASLQVBO-BTJKTKAUSA-N
LogP 3.565 (est)
CAS DataBase Reference 980-71-2(CAS DataBase Reference)
FDA 21 CFR 341.12
EWG's Food Scores 1
FDA UNII IXA7C9ZN03
EPA Substance Registry System 2-Pyridinepropanamine, .gamma.-(4-bromophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1) (980-71-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn,Xi,T,F
Risk Statements  22-39/23/24/25-23/24/25-11
Safety Statements  36-45-36/37-16-7
RIDADR  3249
WGK Germany  3
RTECS  US4025000
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  38220090
NFPA 704
0
2 0

Brompheniramine hydrogen maleate price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B-043 Brompheniramine maleate solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? 980-71-2 1mL $50 2024-03-01 Buy
Sigma-Aldrich 1078008 (±)-Brompheniramine maleate salt 980-71-2 125mg $358 2024-03-01 Buy
TCI Chemical B5167 Brompheniramine Maleate >98.0%(HPLC)(T) 980-71-2 25g $91 2024-03-01 Buy
Alfa Aesar J63922 Brompheniramine maleate 980-71-2 25mg $85.65 2024-03-01 Buy
Alfa Aesar J63922 Brompheniramine maleate 980-71-2 100mg $249 2021-12-16 Buy
Product number Packaging Price Buy
B-043 1mL $50 Buy
1078008 125mg $358 Buy
B5167 25g $91 Buy
J63922 25mg $85.65 Buy
J63922 100mg $249 Buy

Brompheniramine hydrogen maleate Chemical Properties,Uses,Production

Description

Brompheniramine is a first generation antihistamine of the propylamine class. It antagonizes histamine H1 receptors (Ki = 6.06 nM) and also inhibits the reuptake of serotonin and norepinephrine.

Chemical Properties

White Solid

Originator

Dimetane,Robins,US,1957

Uses

An antihistamine and also an inhibitor of serotonin reuptake

Uses

This drug is only available in combination with other medications: Bromfed, Dimetane, Dimetapp, Drixomed, Histatab, Nasahist. The only difference between this agent and chlorpheniramine is the substitution of a bromine for a chlorine atom in brompheniramine.

Uses

Antihistaminic;H1 Antagonist

Definition

ChEBI: The maleic acid salt of brompheniramine. A histamine H1 receptor antagonist, it is used for the symptomatic relief of allergic conditions, including rhinitis and conjunctivitis.

Manufacturing Process

Initially, 4-bromobenzyl-cyanide is reacted with sodium amide and 2- chloropyridine to give bromophenyl-pyridyl acetonitrile. This is then reacted with sodium amide then dimethyl amino ethyl chloride to give 4-bromophenyldimethylaminoethyl- pyridyl acetonitrile. This intermediate is then hydrolyzed and decarboxylated to bromphenirame using 80% H2SO4 at 140°-150°C for 24 hours. The brompheniramine maleate may be made by reaction with maleic acid in ethanol followed by recrystallization from pentanol.

brand name

Dimetane (Wyeth).

Therapeutic Function

Antihistaminic

General Description

Brompheniraminemaleate, (+)2-[p-bromo-α-[2-(dimethylamino)ethyl]benzyl]pyridine bimaleate (Dimetane), differs fromchlorpheniramine by the substitution of a bromine atom forthe chlorine atom. Its actions and uses are like those of chlorpheniramine.It has a half-life of 25 hours, which is almosttwice that of chlorpheniramine.

Side effects

The side effects of this medication are similar to other classes of sedative antihistamines. Some medications include parabens. Patients sensitive to parabens may develop a sensitivity reaction.

Brompheniramine hydrogen maleate Preparation Products And Raw materials

Global( 271)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29880 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED
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TargetMol Chemicals Inc.
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Hefei TNJ Chemical Industry Co.,Ltd.
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AFINE CHEMICALS LIMITED
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Baoji Guokang Bio-Technology Co., Ltd.
0917-3909592 13892490616 gksales1@gk-bio.com China 9312 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739 info@dycnchem.com China 52849 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58

View Lastest Price from Brompheniramine hydrogen maleate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Brompheniramine maleate pictures 2024-11-19 Brompheniramine maleate
980-71-2
US $29.00-48.00 / mg 99.3% 10g TargetMol Chemicals Inc.
Brompheniramine maleate pictures 2024-11-19 Brompheniramine maleate
980-71-2
US $29.00-48.00 / mg 99.3% 10g TargetMol Chemicals Inc.
Brompheniramine Maleate pictures 2023-09-14 Brompheniramine Maleate
980-71-2
US $0.00 / kg 1kg 99.76% 20tons Wuhan Han Sheng New Material Technology Co.,Ltd
2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)pyridinemaleate(1:1) 2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)-pyridinmaleate(1:1) dimegan dimetane dimetanemaleate dimotane g-(4-bromophenyl)-N,N-dimethyl-2-pyridinepropanaminemaleate gamma-(4-bromophenyl)-n,n-dimethyl-2-pyridinepropanamin(z)-2-butenedioate gamma-(4-bromophenyl)-n,n-dimethyl-2-pyridinepropanamin(z)-butenedioate ilvinmaleate parabromdylaminemaleate parabromodylaminemaleate γ-(4-bromophenyl)-N,N-dimethyl-2-pyridinepropanaminemaleate 1-(n,n-dimethylamino)-3-(p-bromophenyl)-3-(alpha-pyridyl)propane maleate 1-p-bromophenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate BROMOPHENIRAMINE MALEATE (+/-)-BROMPHENIRAMINE MALEATE SALT BROMPHENIRAMINE MALEATE SALT brompheniramine hydrogen maleate BROMPHENIRAMINE MALEATE BROMPHENIRAMINEMALEATE,USP BROMPHENIRAMINE MALEATE, PHARMA Bromopheniramine Maleate Salt Brompheniramine Maleate (125 mg) BroMpheniraMine hydr γ-(4-BroMophenyl)-N,N-diMethyl- γ-(4-bromophenyl)-N,N-dimethyl-2-pyridinepropanamine,(2Z)-2-butenedioate (1:1) Brompheniramine maleate solution RS-brompheniramine maleate Brompheniramine maleate CRS Rolabromophen Brompheniramine MaL 3-(4-bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine maleate Brompheniramine hydrogen maleate USP/EP/BP Brompheniramine maleateQ: What is Brompheniramine maleate Q: What is the CAS Number of Brompheniramine maleate Q: What is the storage condition of Brompheniramine maleate Q: What are the applications of Brompheniramine maleate TIANFU-CHEM 980-71-2 Brompheniramine hydrogen maleate Brompheniramine Maleate (1078008) β-Phenyl-γ-aminobutyric acid Brompheniramine maleate in methanol Brompheniramine maleate 100 μg/ml Methanol C10781600 (±)-BrompheniraminEmaleate 980-71-2 80-71-2 C20H23BrN204 C20H23BrN2O4 C16H19BrN2C4H4O4C20H23BrN2O4 C16H19BrN2C4H4O4 C16H19BrN2C4H4O4C20H C16H19BrN2C4H4 C4H4O4C16H19BrN2 Amines Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals