5-Fluoropyrimidine-4,6-diol
- CAS No.
- 106615-61-6
- Chemical Name:
- 5-Fluoropyrimidine-4,6-diol
- Synonyms
- 5-FLUORO-PYRIMIDINE-4,6-DIOL;4,6-Dihydroxy-5-fluoropyrimidine;5-Fluoro-4,6-dihydroxypyrimidine;5-Fluoro-6-hydroxy-4(3H)-pyrimidinone;5-fluoro-4-hydroxy-1H-pyrimidin-6-one;5-fluoro-6-hydroxypyriMidin-4(3H)-one;4(3H)-PyriMidinone, 5-fluoro-6-hydroxy-;4(1H)-Pyrimidinone, 5-fluoro-6-hydroxy- (9CI);5-fluoro-6-hydroxy-3,4-dihydropyrimidin-4-one;5-FLUORO-PYRIMIDINE-4,6-DIOL ISO 9001:2015 REACH
- CBNumber:
- CB2793070
- Molecular Formula:
- C4H3FN2O2
- Molecular Weight:
- 130.08
- MDL Number:
- MFCD09033260
- MOL File:
- 106615-61-6.mol
- MSDS File:
- SDS
5-Fluoropyrimidine-4,6-diol price More Price(26)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | B435445 | 5-Fluoropyrimidine-4,6-diol | 106615-61-6 | 250mg | $55 | 2021-12-16 | Buy |
AK Scientific | X8810 | 5-Fluoropyrimidine-4,6-diol | 106615-61-6 | 1g | $111 | 2021-12-16 | Buy |
Matrix Scientific | 059839 | 5-Fluoropyrimidine-4,6-diol >96% | 106615-61-6 | 1g | $124 | 2021-12-16 | Buy |
ChemScene | CS-W000796 | 5-fluoropyrimidine-4,6-diol | 106615-61-6 | 5g | $155 | 2021-12-16 | Buy |
Matrix Scientific | 059839 | 5-Fluoropyrimidine-4,6-diol >96% | 106615-61-6 | 500mg | $163 | 2021-12-16 | Buy |
5-Fluoropyrimidine-4,6-diol Chemical Properties,Uses,Production
Uses
5-Fluoropyrimidine-4,6-diol is used in preparation of Phenylpyrimidine derivatives and analogs for use as Kynurenine-3-monooxygenase inhibitors.
Preparation
synthesis of 5-Fluoro-4,6-dihydroxypyrimidine: Formamidine acetate (2.06 g, 20 mmol) was added to the solution of sodium (1.38 g, 60 mmol) in anhydrous ethanol (40 mL) and the mixture was heated to reflux. Diethyl 2-fluoromalonate (3.20 g, 18 mmol) was added dropwise over 20 minutes and the mixture was heated at reflux for 6 h. After cooling to room temperature, the solution was evaporated to dryness, the residue was dissolved in water (20 mL), acidified with HCl (5 mL), the precipitate was filtered, washed with water (5 mL), ethanol (2 × 5 mL) and diethyl ether (2 × 5 mL). After drying in vacuo, 5-fluoro-4,6-dihydroxypyrimidine (1.50 g, 64%) was obtained as a brown powder.
m.p.: >300 °C; ([M + H]+ , 131.0244, C4H4FN2O2 requires: [M]+ , 131.0257); IR (neat, cm-1 ) 3053, 2639, 1633, 1547, 1388, 1213; δH (DMSO d6, 400 MHz) 7.90 (1H, s, C-H), 12.38 (2H, bs, OH); δF (DMSO d6, 376 MHz): -178.06 (s); δC (DMSO d6, 100 MHz) 132.79 (d, 1 JCF 235.6, C-F), 144.46 (d, 4 JCF 7.7, C-H), 155.83 (d, 2 JCF 15.0, C-OH); m/z (ASAP) 131 (100%, [M + H]+ ).21a
5-Fluoropyrimidine-4,6-diol Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32835 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29899 | 58 |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8348 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49403 | 58 |
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21149 | 58 |
Allfluoro pharmaceutical co. ltd. | 021-26137118 +8615821363818 | sales@allfluoro.com | China | 5791 | 58 |
View Lastest Price from 5-Fluoropyrimidine-4,6-diol manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2021-12-10 | 5-FLUORO-PYRIMIDINE-4,6-DIOL
106615-61-6
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | ||
2019-07-06 | 5-FLUORO-PYRIMIDINE-4,6-DIOL
106615-61-6
|
US $1.00 / KG | 1KG | 99% | Customized | Career Henan Chemical Co |
- 5-FLUORO-PYRIMIDINE-4,6-DIOL
106615-61-6
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
- 5-FLUORO-PYRIMIDINE-4,6-DIOL
106615-61-6
- US $1.00 / KG
- 99%
- Career Henan Chemical Co