Dalbavancin hydrochloride
- CAS No.
- 2227366-51-8
- Chemical Name:
- Dalbavancin hydrochloride
- Synonyms
- BI-397 hydrochloride;MDL-63397 hydrochloride;Dalbavancin Hydrochloride(Mixture)
- CBNumber:
- CB28029346
- Molecular Formula:
- C88H101Cl3N10O28
- Molecular Weight:
- 1853.17
- MDL Number:
- MFCD32173458
- MOL File:
- 2227366-51-8.mol
Dalbavancin hydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-3579 | Dalbavancinhydrochloride 99.48% | 2227366-51-8 | 1mg | $60 | 2021-12-16 | Buy |
| ChemScene | CS-3579 | Dalbavancinhydrochloride 99.48% | 2227366-51-8 | 5mg | $180 | 2021-12-16 | Buy |
| ChemScene | CS-3579 | Dalbavancinhydrochloride 99.48% | 2227366-51-8 | 10mg | $288 | 2021-12-16 | Buy |
| ChemScene | CS-3579 | Dalbavancinhydrochloride 99.48% | 2227366-51-8 | 25mg | $528 | 2021-12-16 | Buy |
| ChemScene | CS-3579 | Dalbavancinhydrochloride 99.48% | 2227366-51-8 | 50mg | $720 | 2021-12-16 | Buy |
Dalbavancin hydrochloride Chemical Properties,Uses,Production
Uses
Dalbavancin hydrochloride (MDL-63397 hydrochloride) is a semisynthetic lipoglycopeptide antibiotic with potent bactericidal activity against Gram-positive bacteria. Dalbavancin hydrochloride inhibits Staphylococcus aureus and Bacillus anthracis with MIC90s of 0.06 μg/mL and 0.25 μg/mL, respectively[1][2].
Biological Activity
Dalbavancin hydrochloride(MDL-63397 hydrochloride) is a semi-synthetic lipoglycopeptide antibiotic with potent bactericidal activity against Gram-positive bacteria. Dalbavancin hydrochloride inhibits Staphylococcus aureus and Bacillus anthracis with MIC90 of 0.06 μg/mL and 0.25 μg/mL, respectively.
in vitro
Dalbavancin is a parenterally administered semisynthetic lipoglycopeptide developed to combat infections caused by resistant gram-positive pathogens. Dalbavancin exhibits potent in vitro bactericidal activity against gram-positive pathogens including S. aureus (MRSA ), VISA, and non-VanA strains of VRE. Dalbavancin is developed for the treatment of complicated skin and skin structure infections (cSSSIs), predominantly those caused by MRSA and β-hemolytic streptococci , organisms against which it has shown greater potency than existing glycopeptide therapeutic agents.
in vivo
Dalbavancin (15-240 mg/kg; intraperitoneal injection; every 36 h or 72 h; for 14 days; female BALB/c mice) treatment has a survival rate of 80% to 100% of mice with all dose regimens.
| Animal Model: | Female BALB/c mice (6-8 weeks) challenged with Ames strain of B . anthracis |
| Dosage: | 15 mg/kg, 30 mg/kg, 60 mg/kg, 120 mg/kg, 240 mg/kg |
| Administration: | Intraperitoneal injection ; every 36 h or 72 h; for 14 days |
| Result: | The efficacy was 80 to 100%, as determined by the rate of survival at 42 days, when treatment was initiated 24 h postchallenge with regimens of 15 to 120 mg/kg every 36 h or 30 to 240 mg/kg every 72 h. |
IC 50
Glycopeptide
References
[1] Heine HS, et al. Activity of dalbavancin against Bacillus anthracis in vitro and in a mouse inhalation anthrax model. Antimicrob Agents Chemother. 2010 Mar;54(3):991-6. DOI:10.1128/AAC.00820-09
[2] Bennett JW, et al. Dalbavancin in the treatment of complicated skin and soft-tissue infections: a review. Ther Clin Risk Manag. 2008 Feb;4(1):31-40. DOI:10.2147/tcrm.s46
Dalbavancin hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Dalbavancin hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +8618501500038 | 3899766280@qq.com | China | 26362 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Hubei Zhongshan Medical Technology Co., Ltd | 027-61907345 13397111514 | w13397111514@163.com | China | 1011 | 58 |
| Shanghai Minkai Biological Technology Co., Ltd | 021-021-52919136 17315815539 | 2804155403@qq.com | China | 170 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4729 | 58 |
View Lastest Price from Dalbavancin hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2024-10-24 | Dalbavancin hydrochloride
2227366-51-8
|
US $98.00 / mg | 10g | TargetMol Chemicals Inc. |
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- Dalbavancin hydrochloride
2227366-51-8
- US $98.00 / mg
- TargetMol Chemicals Inc.