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SK33

SK33 Structure
SK33 structure
CAS No.
1928724-23-5
Chemical Name:
SK33
Synonyms
SK33;3-(3,5-Bis(trifluoromethyl)phenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide;Propanamide, 3-[3,5-bis(trifluoromethyl)phenoxy]-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-;Androgen Receptor,inhibit,androgen,PC3,cancer,prostate,SK 33,SK-33,Inhibitor,tissue,LNCaP,SK33,analogues,cells
CBNumber:
CB28054542
Molecular Formula:
C20H13F9N2O3
Molecular Weight:
500.31
MDL Number:
MFCD32174353
MOL File:
1928724-23-5.mol
Last updated:2024-07-02 08:55:04
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SK33 Properties

Boiling point 540.5±50.0 °C(Predicted)
Density 1.53±0.1 g/cm3(Predicted)
storage temp. 4°C, protect from light
solubility DMSO : 100 mg/mL (199.88 mM; Need ultrasonic)
form Solid
pka 12.12±0.29(Predicted)
color White to off-white

SK33 Chemical Properties,Uses,Production

Biological Activity

SK33, a trifluoromethylated enobosarm analog, is a potent, and tissue selective anti-androgen. SK33reduces androgen receptor (AR) transcriptional activity[1]. In LNCaPAR+ cells, SK33, demonstrates a significantly potent activity with IC50=0.2 μM. SK33 decreases cells entering S-phase in LNCaP cells. Treatment of LNCaP/BicR cells with increasing concentrations of SK33 for 96 hours results in a dose-dependent response and an inhibition of cell growth, with IC50 of approximately 5 μM for SK33[1]. SK33 (50 mg/kg; s.c.; 24 hours) inhibits AR transcriptional activity[1].

References

[1]. Dart DA, et al. Novel Trifluoromethylated Enobosarm Analogues with Potent Antiandrogenic Activity In Vitro and Tissue Selectivity In Vivo.Mol Cancer Ther. 2018 Sep;17(9):1846-1858.

SK33 Preparation Products And Raw materials

Raw materials

Preparation Products

SK33 Suppliers

Global( 9)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 3770 55
JinOu Biomedical (Nanjing) Co., Ltd. 13000000000 jinoupharma@163.com China 11732 58
Bide Pharmatech Ltd. 400-1647117 15221909166 product02@bidepharm.com China 63720 58
Changzhou Bojia Biomedical Technology Co., Ltd. 2122619822 czbjpharma@126.com China 18488 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 23963 58
Suzhou Haiben Pharmaceutical Co., Ltd 14760821013 14760821013 1816280386@qq.com China 6166 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 021-59167510 18117107507 vip@med-life.cn China 5012 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050 cindy.huang@synzest.com China 12007 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Tianjin Kailiqi Biotechnology Co., Ltd. 55
JinOu Biomedical (Nanjing) Co., Ltd. 58
Bide Pharmatech Ltd. 58
Changzhou Bojia Biomedical Technology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Suzhou Haiben Pharmaceutical Co., Ltd 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 58
Nanjing Shizhou Biology Technology Co.,Ltd 58

SK33 Spectrum

SK33(1928724-23-5)1HNMR
SK33 Androgen Receptor,inhibit,androgen,PC3,cancer,prostate,SK 33,SK-33,Inhibitor,tissue,LNCaP,SK33,analogues,cells Propanamide, 3-[3,5-bis(trifluoromethyl)phenoxy]-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl- 3-(3,5-Bis(trifluoromethyl)phenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide 1928724-23-5