3H-1,2,4-Triazol-3-one, 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluoro[1,1'-biphenyl]-3-yl)-4-morpholinyl]methyl]-1,2-dihydro-, rel-

3H-1,2,4-Triazol-3-one, 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluoro[1,1'-biphenyl]-3-yl)-4-morpholinyl]methyl]-1,2-dihydro-, rel- structure

CAS No.: 2206135-44-4

Chemical Name:: 3H-1,2,4-Triazol-3-one, 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluoro[1,1'-biphenyl]-3-yl)-4-morpholinyl]methyl]-1,2-dihydro-, rel-

Synonyms: 3-Des-(4-fluorophenyl) 3-(2R,3S,R)-(4-Fluorobiphen-3-yl) Aprepitant;3H-1,2,4-Triazol-3-one, 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluoro[1,1'-biphenyl]-3-yl)-4-morpholinyl]methyl]-1,2-dihydro-, rel-

CBNumber:: CB28140414

Molecular Formula:: C29H25F7N4O3

Molecular Weight:: 610.52

MDL Number:

MOL File:: 2206135-44-4.mol

Request For Quotation

3H-1,2,4-Triazol-3-one, 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluoro[1,1'-biphenyl]-3-yl)-4-morpholinyl]methyl]-1,2-dihydro-, rel- Properties

Density	1.44±0.1 g/cm3(Predicted)
pka	8.05±0.20(Predicted)

3H-1,2,4-Triazol-3-one, 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluoro[1,1'-biphenyl]-3-yl)-4-morpholinyl]methyl]-1,2-dihydro-, rel- Chemical Properties,Uses,Production

Uses

3-Des-(4-fluorophenyl) 3-(2R,3S,R)-(4-Fluorobiphen-3-yl) Aprepitant is a derivative of Aprepitant (A729800), which is a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.

3H-1,2,4-Triazol-3-one, 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluoro[1,1'-biphenyl]-3-yl)-4-morpholinyl]methyl]-1,2-dihydro-, rel- Preparation Products And Raw materials

Raw materials

Preparation Products

3H-1,2,4-Triazol-3-one, 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluoro[1,1'-biphenyl]-3-yl)-4-morpholinyl]methyl]-1,2-dihydro-, rel- Suppliers

Global( 2)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ChemStrong Scientific Co.,Ltd	0755-0755-66853366 13670046396	sales@chem-strong.com	China	18045	56
Nantong Hanfang Biotechnology Co. , Ltd.	18616537568	hanfangpharma@126.com	China	30968	58

Supplier	Advantage
ChemStrong Scientific Co.,Ltd	56
Nantong Hanfang Biotechnology Co. , Ltd.	58

3-Des-(4-fluorophenyl) 3-(2R,3S,R)-(4-Fluorobiphen-3-yl) Aprepitant 3H-1,2,4-Triazol-3-one, 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluoro[1,1'-biphenyl]-3-yl)-4-morpholinyl]methyl]-1,2-dihydro-, rel- 2206135-44-4