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Urea, N-(3,4-dichlorophenyl)-N'-[3-[(4-quinazolinylamino)methyl]phenyl]-

Urea, N-(3,4-dichlorophenyl)-N'-[3-[(4-quinazolinylamino)methyl]phenyl]- structure

CAS No.: 1648546-79-5

Chemical Name:: Urea, N-(3,4-dichlorophenyl)-N'-[3-[(4-quinazolinylamino)methyl]phenyl]-

Synonyms: CAY10773;CAY-10773,CAY10773;Anticancer agent 251;N-(3,4-dichlorophenyl)-N′-[3-[(4-quinazolinylamino)methyl]phenyl]-urea;Urea, N-(3,4-dichlorophenyl)-N'-[3-[(4-quinazolinylamino)methyl]phenyl]-

CBNumber:: CB28433343

Molecular Formula:: C22H17Cl2N5O

Molecular Weight:: 438.31

MDL Number:

MOL File:: 1648546-79-5.mol

Last updated:2024-10-28 23:16:16

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Urea, N-(3,4-dichlorophenyl)-N'-[3-[(4-quinazolinylamino)methyl]phenyl]- Properties

Boiling point	547.5±50.0 °C(Predicted)
Density	1.488±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 1 mg/ml,DMSO: 1 mg/ml
form	A crystalline solid
pka	12.87±0.70(Predicted)

Urea, N-(3,4-dichlorophenyl)-N'-[3-[(4-quinazolinylamino)methyl]phenyl]- Chemical Properties,Uses,Production

Biological Activity

CAY10773 is a derivative of the ferroptosis inducer sorafenib .1 It selectively inhibits proliferation of BEL-7402, MGC803, and T24 bladder cancer cells (IC50s = 5.77, 5.21 and 3.97 μM, respectively) over non-cancerous HCV-29 cells (IC50 = 23.19 μM). CAY10773 induces apoptosis in T24 cells when used at concentrations ranging from 2 to 6 μM but induces ferroptosis at concentrations greater than or equal to 6 μM with 10 hour or longer incubation times. It increases the production of reactive oxygen species (ROS) and decreases the mitochondrial membrane potential in T24 cells. CAY10773 (≥6 μM) also induces autophagy with incubation times longer than eight hours.

References

1.Chen, J.-N., Li, T., Cheng, L., et al.Synthesis and in vitro anti-bladder cancer activity evaluation of quinazolinyl-arylurea derivativesEur. J. Med. Chem.205112661(2020)

Urea, N-(3,4-dichlorophenyl)-N'-[3-[(4-quinazolinylamino)methyl]phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Urea, N-(3,4-dichlorophenyl)-N'-[3-[(4-quinazolinylamino)methyl]phenyl]- Suppliers

Global( 10)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
Changzhou Furuisi Biotechnology Co., Ltd	0519-85524369	3477467573@qq.com	China	8617	58
Jinan Jiuli Biotechnology Co. , Ltd.	15865264761	486064515@qq.com	China	4728	58
ChemeGen 中国	18818260767	2625930290@qq.com	China	6973	58
Beijing Biocreative Technology Co., Ltd.	15522676233	3007606172@qq.com	China	1248	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24644	58
Shanghai Yiyan Biotechnology Co. , Ltd.	021-69985186 13611928337	3427709316@qq.com	China	7978	58
Nanjing Tengyi Biotechnology Co., Ltd	025-58851786 17714337195	sales@tybiochem.com	China	6829	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Shanghai EFE Biological Technology Co., Ltd.	58
Changzhou Furuisi Biotechnology Co., Ltd	58
Jinan Jiuli Biotechnology Co. , Ltd.	58
ChemeGen 中国	58
Beijing Biocreative Technology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Shanghai Yiyan Biotechnology Co. , Ltd.	58
Nanjing Tengyi Biotechnology Co., Ltd	58

View Lastest Price from Urea, N-(3,4-dichlorophenyl)-N'-[3-[(4-quinazolinylamino)methyl]phenyl]- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-10-28	CAY10773 1648546-79-5	US $1170.00-170.00 / mg			10g	TargetMol Chemicals Inc.

CAY10773
1648546-79-5
US $1170.00-170.00 / mg
TargetMol Chemicals Inc.

Urea, N-(3,4-dichlorophenyl)-N'-[3-[(4-quinazolinylamino)methyl]phenyl]- CAY10773 CAY-10773,CAY10773 N-(3,4-dichlorophenyl)-N′-[3-[(4-quinazolinylamino)methyl]phenyl]-urea Anticancer agent 251 1648546-79-5