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(R)-2-(2-Chlorophenyl)pyrrolidine

CAS No.
823188-58-5
Chemical Name:
(R)-2-(2-Chlorophenyl)pyrrolidine
Synonyms
(R)-2-(2-Chlorophenyl)pyrrolidine;(2R)-2-(2-chlorophenyl)pyrrolidine;Pyrrolidine,2-(2-chlorophenyl)-, (2R)-
CBNumber:
CB2875729
Molecular Formula:
C10H12ClN
Molecular Weight:
181.66
MDL Number:
MFCD06762524
MOL File:
823188-58-5.mol
MSDS File:
SDS
Last updated:2023-09-28 09:37:16

(R)-2-(2-Chlorophenyl)pyrrolidine Properties

Boiling point 254.1±33.0 °C(Predicted)
Density 1.129±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pka 9.45±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

(R)-2-(2-Chlorophenyl)pyrrolidine price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth Carbosynth FC151298 (R)-2-(2-Chlorophenyl)pyrrolidine 823188-58-5 250mg $267.5 2021-12-16 Buy
Biosynth Carbosynth FC151298 (R)-2-(2-Chlorophenyl)pyrrolidine 823188-58-5 500mg $465 2021-12-16 Buy
American Custom Chemicals Corporation CCH0038887 (R)-2-(2-CHLOROPHENYL)PYRROLIDINE 95.00% 823188-58-5 5MG $505.21 2021-12-16 Buy
Biosynth Carbosynth FC151298 (R)-2-(2-Chlorophenyl)pyrrolidine 823188-58-5 50mg $77 2021-12-16 Buy
Activate Scientific AS8672 (R)-2-(2-Chlorophenyl)pyrrolidine 95+% ee 823188-58-5 1g $729 2021-12-16 Buy
Product number Packaging Price Buy
FC151298 250mg $267.5 Buy
FC151298 500mg $465 Buy
CCH0038887 5MG $505.21 Buy
FC151298 50mg $77 Buy
AS8672 1g $729 Buy

(R)-2-(2-Chlorophenyl)pyrrolidine Chemical Properties,Uses,Production

Chemical Properties

Flashing point: 107.5 °C . Vapour pressure: 0.0176mmHg at 25°C. (R)-2-(2-Chlorophenyl)pyrrolidine is a chiral molecule whose optical isomer is (S)-2-(2-Chlorophenyl)pyrrolidine.

Physical properties

A colorless crystal

Uses

(R)-2-(2-Chlorophenyl)pyrrolidine can be used as an intermediate for organic synthesis.

Synthesis

To a dry Schlenk flask under nitrogen is added 0.540 g of (R, R)- (+)-ETHYLENE-1, 2- bis (N5-4, 5,6, 7-TETRAHYDRO-L-INDENYL) titanium difluoride and 120 mL of dry THF. To this solution are added under nitrogen in the following order: 2- (2-chlorophenyl)-pyrroline (15 g), phenylsilane (15 g), pyrrolidine (0.48 mL), and MeOH (0.24 mL). The solution is stirred at RT for 48 h, then the mixture is diluted with 350 mL of diethylether and carefully added with vigorous stirring to 1200 mL of 1 M HCI. The aqueous layer is separated and extracted with three portions of diethyl ether (300 mL each). The aqueous layer is made basic with 3M NAOH and extracted with 5 portions of diethyl ether (200 mL each). The combined ether layers are dried over magnesium sulfate and concentrated in vacuo. The residue is purified by vacuum transfer to give (R)-2-(2-Chlorophenyl)pyrrolidine (15 g, 93%) as a colorless oil.

129540-25-6
823188-58-5
Synthesis of (R)-2-(2-Chlorophenyl)pyrrolidine from 5-(2-CHLOROPHENYL)-3,4-DIHYDRO-2H-PYRROLE

(R)-2-(2-Chlorophenyl)pyrrolidine Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-2-(2-Chlorophenyl)pyrrolidine Suppliers

Global( 46)Suppliers
Supplier Tel Email Country ProdList Advantage
Tianjin Xinghan Biotechnology Co., Ltd
+8618698089028 1725517238@qq.com China 2479 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49374 58
Golden Pharma Co., Limited
+undefined18958062155 sales@zjgoldpharm.com China 5899 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
Suzhou ARTK Medchem Co., Ltd.
+86-512-68323658 +86-18168183658 sales1@artkmedchem.com China 39004 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131957 58
Tianjin Xinghan Biotechnology Co., Ltd 13230698506 18698089028 1725517238@qq.com China 5009 58
LABTER PHARMATECH(BEIJING) CO.,LTD 010-56330744 18310155299 sales@labter.com.cn China 23967 55
Chongqing Acemol Technology Co.,Ltd 023-86822659,企业QQ3004125759 18611316925 sales@acemol.com China 992 55
Shanghai CR Corporation Limited 021-80270511; 4006653949 fred.wen@crcorporation.cn China 10044 58
(2R)-2-(2-chlorophenyl)pyrrolidine (R)-2-(2-Chlorophenyl)pyrrolidine Pyrrolidine,2-(2-chlorophenyl)-, (2R)- 823188-58-5 API intermediates