phenindamine
- CAS No.
- 82-88-2
- Chemical Name:
- phenindamine
- Synonyms
- Nu-1504;Thephorin;phenindamine;phenindamine USP/EP/BP;Phenindamine Hydrogen Tartrate;2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine;1H-Indeno2,1-cpyridine, 2,3,4,9-tetrahydro-2-methyl-9-phenyl-;2,3,4,9-tetrahydro-2-methyl-9-phenyl-1H-indeno(2,1-c)pyridine
- CBNumber:
- CB2875734
- Molecular Formula:
- C19H19N
- Molecular Weight:
- 261.36
- MDL Number:
- MFCD00865675
- MOL File:
- 82-88-2.mol
| Melting point | 90-91° |
|---|---|
| Density | 1.17 |
| pka | pKa 8.11±0.08(H2O,t undefined,I=0.30(NaCl)) (Uncertain) |
| FDA UNII | 772BQ8KSST |
| ATC code | R06AX04 |
phenindamine Chemical Properties,Uses,Production
Originator
Thephorin ,Roche, US,1947
Definition
ChEBI: Phenindamine is an indene.
Manufacturing Process
A mixture of 750 grams of 1-methyl-3-benzoyl-4-hydroxy-4-phenylpiperidine and 2,500 cc of 48% hydrobromic acid is refluxed for about 20 minutes. It is then poured into 8 liters of water. An oily precipitate appears which on standing crystallizes. It is filtered and crystallized from about 3.5 liters of alcohol. 2-Methyl-9-phenyl-2,3-dihydrel-pyridindene hydrobromide, MP 201°203°C, is obtained.
A mixture of 680 grams of 2-methyl-9-phenyl-2,3-dihydrol-pyridindene hydrobromide, 6,000 cc of water and about 100 grams of Raney-nickel catalyst is hydrogenated at room temperature and at about 1,000 lb pressure for a period of three hours. The catalyst is filtered. The clear filtrate is treated with a solution of 240 grams potassium thiocyanate in 400 cc of water. A heavy solid precipitates from which the supernatant liquid is decanted.
The residue is dissolved in 10 liters of boiling alcohol with stirring in the presence of nitro gen. The solution is cooled to room temperature under nitrogen, and then allowed to stand overnight. 2-Methyl-9-phenyl-tetrahydro1-pyridindene thiocyanate separates in crystals of MP 188°-189°C. From the concentrated filtrate an additional amount is obtained. The corresponding free base, prepared by treating the slightly soluble thiocyanate in aqueous suspension with sodium hydroxide and extracting with ether, has a MP of 90°91°C. It forms a tartrate of MP 160°C.
The starting material was prepared by reacting acetophenone, methylamine and formaldehyde followed by treatment of the intermediate with sodium hydroxide.
brand name
Thephorin (Hoffmann-LaRoche).
Therapeutic Function
Antihistaminic
phenindamine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1087@dideu.com | China | 3154 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 8670 | 58 |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19884 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | info@synzest.com | China | 9286 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 18351873721 | helen.zhang@synzest.com | China | 8295 | 58 |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 17691182729 18161915376 | 1046@dideu.com | China | 10001 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24644 | 58 |
| Shanghai Saikerui Biotechnology Co. , Ltd. | 021-58000709 15900491054 | info@scrbio.com | China | 10329 | 58 |
| Aribo Pharmatech Co., Ltd. | 19951442182 | sales@aribopharm.com | China | 2468 | 58 |
View Lastest Price from phenindamine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-01-03 | Phenindamine
82-88-2
|
US $1.00-1.00 / KG | 1g | 99% | 50tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2024-11-19 | Phenindamine
82-88-2
|
US $1520.00-2500.00 / mg | 10g | TargetMol Chemicals Inc. |
-
- Phenindamine
82-88-2
- US $1.00-1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- Phenindamine
82-88-2
- US $1520.00-2500.00 / mg
- TargetMol Chemicals Inc.