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ChemicalBook >> CAS DataBase List >>2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(hydroxymethyl)-7-(phenylsulfonyl)-

2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(hydroxymethyl)-7-(phenylsulfonyl)-

2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(hydroxymethyl)-7-(phenylsulfonyl)- Structure
2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(hydroxymethyl)-7-(phenylsulfonyl)- structure
CAS No.
1513860-41-7
Chemical Name:
2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(hydroxymethyl)-7-(phenylsulfonyl)-
Synonyms
2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(hydroxymethyl)-7-(phenylsulfonyl)-
CBNumber:
CB29924392
Molecular Formula:
C26H24F2N4O6S
Molecular Weight:
558.55
MDL Number:
MOL File:
1513860-41-7.mol
Last updated:2024-07-02 08:55:04
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2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(hydroxymethyl)-7-(phenylsulfonyl)- Properties

Boiling point 773.6±70.0 °C(Predicted)
Density 1.48±0.1 g/cm3(Predicted)
storage temp. 4°C, away from moisture and light
pka 13.65±0.10(Predicted)
form Solid
color Off-white to light yellow

2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(hydroxymethyl)-7-(phenylsulfonyl)- Chemical Properties,Uses,Production

Biological Activity

FGFR-IN-1 is a potent FGFR inhibitor with an IC50 of <100 nM for FGFR1, FGFR2, and FGFR3, respectively (patent US20130338134A1, example 219)[1].

References

[1]. Liangxing Wu, et al. Substituted tricyclic compounds as fgfr inhibitors. US20130338134A1.

2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(hydroxymethyl)-7-(phenylsulfonyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(hydroxymethyl)-7-(phenylsulfonyl)- Suppliers

Global( 2)Suppliers
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Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 021-59167510 18117107507 vip@med-life.cn China 5012 58
Supplier Advantage
Aladdin Scientific 		58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 58
2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(hydroxymethyl)-7-(phenylsulfonyl)- 1513860-41-7 C26H24F2N4O6S