Nestoron
- CAS No.
- 7759-35-5
- Chemical Name:
- Nestoron
- Synonyms
- ST 1435;NESTORON;NESTORONE;Elcometrine;Nestorone Acetate;Nestoron (ST-1435);Norgestone acetate;Segesterone Acetate;Nestoron, 10 mM in DMSO;ELCOMETRINE;NESTORONE;ST-1435;ST1435
- CBNumber:
- CB31011778
- Molecular Formula:
- C23H30O4
- Molecular Weight:
- 370.48
- MDL Number:
- MFCD01711303
- MOL File:
- 7759-35-5.mol
| Melting point | 178-179° |
|---|---|
| alpha | D21 -105° (c = 1.2 in chloroform) |
| Boiling point | 420.37°C (rough estimate) |
| Density | 1.0550 (rough estimate) |
| refractive index | 1.4433 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble5mg/mL, clear |
| form | powder |
| color | white to beige |
| InChIKey | CKFBRGLGTWAVLG-GOMYTPFNSA-N |
| EWG's Food Scores | 1 |
| FDA UNII | 9AMX4Q13CC |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H351-H361 |
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501-P201-P202-P281-P308+P313-P405-P501 |
| WGK Germany | 3 |
Nestoron price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0550 | Nestorone ≥97% (HPLC) | 7759-35-5 | 10mg | $96.1 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0550 | Nestorone ≥97% (HPLC) | 7759-35-5 | 50mg | $372 | 2024-03-01 | Buy |
| Cayman Chemical | 26441 | Segesterone Acetate | 7759-35-5 | 10mg | $78 | 2024-03-01 | Buy |
| Cayman Chemical | 26441 | Segesterone Acetate | 7759-35-5 | 25mg | $183 | 2024-03-01 | Buy |
| Cayman Chemical | 26441 | Segesterone Acetate | 7759-35-5 | 5mg | $44 | 2024-03-01 | Buy |
Nestoron Chemical Properties,Uses,Production
Uses
Segesterone Acetate has been used to study the: comparison of androgenic and estrogenic properties of progestins used in contraception and hormone therapy; impact on hepatic estrogen-sensitive proteins by 1-yr contraceptive vaginal ring delivering Nestorone and ethinyl estradiol.
Definition
ChEBI: Elcometrine is a corticosteroid hormone.
Pharmacokinetics
Elcometrine is a member of the 19-norprogesterone class of pr ogestins. when administered subcuta neously (implant), intravaginally (vaginal ring), or transdermally, elcometrine is an exceptionally potent progestin. It is 100-fold more potent when administered subcutaneously than when delivered orally. Its oral bioavaiability is only 10%，with a half life of just 1 to 2 hours because of rapid metabolism. The C16 methylene functionality substantially increases its affinity for the progesterone receptor.
Clinical Use
Because of its antiestrogenic action, elcometrine also can be administered transdermally along with estradiol as a treatment for menopausal symptoms .
in vivo
Nestoron (400 μCi 3H Nestoron/kg BW; subcutaneous injection; female Sprague-Dawley rats) treatment results in the Cmax in the blood and plasma are 58.1 and 95.5 ng equiv. 3H Nestoron/g, with t1/2 of 15.6 hours. Approximately, 81.4% and 7.62% of the administered dose is excreted via feces and urine, respectively[1].
| Animal Model: | 27 adult, female, Sprague-Dawley rats (200-225 g; age: 8 weeks)[1] |
| Dosage: | 400 μCi 3H Nestorone/kg BW |
| Administration: | Subcutaneous injection (Pharmacokinetic study) |
| Result: | The mean peak concentrations of radioactivity (Cmax) in the blood and plasma were 58.1 and 95.5 ng equiv./g, with t1/2 of 15.6 hours. Approximately, 81.4% and 7.62% of the administered dose was excreted via feces and urine, respectively. |
Nestoron Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29858 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49732 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32202 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
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