Marimastat
- CAS No.
- 154039-60-8
- Chemical Name:
- Marimastat
- Synonyms
- TMH;GI 5712;BB 2516;TA 2516;CS-1627;KB-R 8898;Marimastat;Marimistat;Marimastat(BB-2516);BB 2516; MARIMISTAT
- CBNumber:
- CB31073538
- Molecular Formula:
- C15H29N3O5
- Molecular Weight:
- 331.41
- MDL Number:
- MFCD00866242
- MOL File:
- 154039-60-8.mol
- MSDS File:
- SDS
Melting point | 148℃ |
---|---|
Density | 1.140±0.06 g/cm3(Predicted) |
RTECS | EJ6665000 |
storage temp. | -20°C |
solubility | DMSO: ≥20mg/mL |
form | White solid |
pka | 9.44±0.40(Predicted) |
color | White to gray |
NCI Dictionary of Cancer Terms | marimastat |
FDA UNII | D5EQV23TDS |
NCI Drug Dictionary | marimastat |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319-H335 |
Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a |
WGK Germany | 3 |
HS Code | 29241990 |
Marimastat price More Price(44)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | M2699 | Marimastat ≥98% (HPLC) | 154039-60-8 | 5mg | $221 | 2024-03-01 | Buy |
Sigma-Aldrich | 444289 | Marimastat | 154039-60-8 | 5mg | $289 | 2024-03-01 | Buy |
Alfa Aesar | J67288 | Marimastat, 98% | 154039-60-8 | 1mg | $126 | 2023-06-20 | Buy |
Alfa Aesar | J67288 | Marimastat, 98% | 154039-60-8 | 10mg | $286 | 2023-06-20 | Buy |
Cayman Chemical | 14869 | Marimastat ≥98% | 154039-60-8 | 1mg | $44 | 2024-03-01 | Buy |
Marimastat Chemical Properties,Uses,Production
Uses
Marimastat acts as a matrix metalloproteinase inhibitor in the treatment of various cancers, and pathological occurrences such as arthritis and atherosclerosis.
Uses
Marimastat has been used as an inhibitor of:
- metalloproteinase 2/9 (MMP2/9), to study its effects on exercise-mediated interleukin-6 (IL-6) release in mice
- metalloproteinase, to determine protease activity in Pseudomonas aeruginosa cultures
- metalloproteinase 10 (MMP10), to study its effect on monoclonal antibody H3 binding to MMP10
Uses
Antineoplastic (matrix metalloproteinase inhibitor).
Definition
ChEBI: Marimastat is a secondary carboxamide resulting from the foraml condensation of the carboxy group of (2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoic acid with the alpha-amino group of N,3-dimethyl-L-valinamide. It has a role as an antineoplastic agent and a matrix metalloproteinase inhibitor. It is a secondary carboxamide and a hydroxamic acid.
General Description
An orally active peptidyl hydroxamate-based broad-spectrum MMP inhibitor (IC50 in nM = 5, 6, 200, 20, 2, 1.8 and 3.8 for MMP-1, -2, -3, -7, -8, -14 and TACE, respectively) that targets both the substrate binding site and the active-site Zn2+. Marimastate is widely used in studying the involvement of MMPs in various cellular and pathological processes both in vitro and in vivo.
Biological Activity
Broad spectrum inhibitor of matrix metalloprotease (MMP) (IC 50 values are 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively). In vivo inhibits peritoneal dissemination of human gastric cancer cells through inhibition of tumor angiogenesis.
Biochem/physiol Actions
Marimastat is a broad spectrum matrix metalloprotease (MMP) inhibitor
storage
Store at -20°C
Marimastat Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5873 | 58 |
Alpha Biopharmaceuticals Co., Ltd | +86-15542445688 | sales@alabiochem.com | China | 888 | 58 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9265 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32835 | 60 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29821 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9316 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
View Lastest Price from Marimastat manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-08-15 | Marimastat
154039-60-8
|
US $40.00-40.00 / kg | 1kg | 0.99 | 10 tons | Hebei Yanxi Chemical Co., Ltd. | ||
2021-07-13 | Marimastat
154039-60-8
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | ||
2021-07-10 | Marimastat
154039-60-8
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
- Marimastat
154039-60-8
- US $40.00-40.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
- Marimastat
154039-60-8
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
- Marimastat
154039-60-8
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd