ChemicalBook >> CAS DataBase List >>Pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]-
Pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]-
![Pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]- Structure](CAS/20210305/GIF/2377491-54-6.gif)
- CAS No.
- 2377491-54-6
- Chemical Name:
- Pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]-
- Synonyms
- AGI-43192;AGI 43192,AGI43192;8-(4-Chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]pyrido[4,3-d]pyrimidin-7(6H)-one;Pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]-
- CBNumber:
- CB310872009
- Molecular Formula:
- C23H16ClF3N6O
- Molecular Weight:
- 484.86
- MDL Number:
- MOL File:
- 2377491-54-6.mol
Last updated:2024-07-02 08:55:04
Pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]- Properties
| Boiling point | 601.1±65.0 °C(Predicted) |
|---|---|
| Density | 1.51±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 83.33 mg/mL (171.86 mM; ultrasonic and warming and heat to 60°C) |
| pka | 6.69±0.20(Predicted) |
| form | Solid |
| color | Light yellow to yellow |
Pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]- Chemical Properties,Uses,Production
Biological Activity
AGI-43192 is a potent inhibitor of methionine adenosyltransferase 2A (MAT2A). AGI-43192 is a potent, but limited brain-penetrant compound. AGI-43192 has the potential for exploring the effects of SAM modulation in the central nervous system (CNS) and research of cancer disease[1].
References
[1]. Li M, et al. Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious Leads. J Med Chem. 2022;65(6):4600-4615.
Pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]- Preparation Products And Raw materials
Raw materials
Preparation Products
Pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]- Suppliers
Global( 8)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd | 15317229551 | 15151849396@163.com | China | 997 | 58 |
| Chengdu PEIP Pharmaceutical Technology Co., LTD. | 028-61715638 18011352545 | 1242335275@qq.com | China | 403 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| Nanjing Tengyi Biotechnology Co., Ltd | 025-58851786 17714337195 | sales@tybiochem.com | China | 5593 | 58 |
| https://hanhongsci.com/ | 021-54306202 18917919676 | info@hanhongsci.com | China | 29990 | 58 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | syeu@accelachem.com | China | 11712 | 58 |
Pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]- Spectrum
Pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]-
AGI-43192
AGI 43192,AGI43192
8-(4-Chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]pyrido[4,3-d]pyrimidin-7(6H)-one
2377491-54-6