Defosfamide

CAS No.
3733-81-1
Chemical Name:
Defosfamide
Synonyms
B-612;B 612;Mitarson;Defosfamide;Desmofosfamide;Desmophosphamidum;3-[[bis(2-chloroethyl)amino-(2-chloroethoxy)phosphoryl]amino]propan-1-ol;Phosphorodiamidic acid, N,N-bis(2-chloroethyl)-N'-(3-hydroxypropyl)-, 2-chloroethyl ester
CBNumber:
CB31178431
Molecular Formula:
C9H20Cl3N2O3P
Molecular Weight:
341.6
MDL Number:
MFCD00866553
MOL File:
3733-81-1.mol
MSDS File:
SDS
Last updated:2023-07-14 17:44:09

Defosfamide Properties

Boiling point 442.8±55.0 °C(Predicted)
Density 1.337±0.06 g/cm3(Predicted)
pka 14.92±0.10(Predicted)
FDA UNII 0W33021S30

Defosfamide price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation API0011177 DEFOSFAMIDE 95.00% 3733-81-1 5MG $497.98 2021-12-16 Buy
Product number Packaging Price Buy
API0011177 5MG $497.98 Buy

Defosfamide Chemical Properties,Uses,Production

Originator

Mitarson,Asta-Werke,W. Germany,1961

Manufacturing Process

A solution of 8 g of ethylene chlorohydrin and 10.2 g of triethylamine in 50 cc of absolute dioxane is slowly added dropwise to a solution of 25.9 g of N,Nbis-(β-chloroethyl)-phosphoric acid amide dichloride in 100 cc of absolute dioxane. The mixture is then heated for 2 hours at 60°C. After cooling, a solution of 7.5 g of 1,3-propanolamine and 10.2 g of triethylamine in 50 cc of absolute dioxane is added dropwise while stirring well and at a temperature up to 30°C. The mixture is left to stand for another 12 hours. The liquid is filtered off with suction from the precipitated triethyamine hydrochloride. The filtrate is filtered through carbon and concentrated by evaporation in water-jet vacuum at 40°C. The residue is dissolved in a little alcohol. Copious amounts of ether are added and the solution is left overnight in a refrigerator. It is then again filtered through carbon, the ether is evaporated and the residual volatile fractions are removed under high vacuum at 55°C. The result is a yellowish, fairly viscous oil, which is insoluble in water.

Therapeutic Function

Antineoplastic

Defosfamide Preparation Products And Raw materials

Raw materials

Preparation Products

Defosfamide Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
Career Henan Chemica Co
+86-0371-86658258 15093356674; laboratory@coreychem.com China 30254 58
Supplier Advantage
Career Henan Chemica Co
58

3733-81-1(Defosfamide)Related Search:

Defosfamide B 612 B-612 Desmofosfamide Desmophosphamidum Mitarson 3-[[bis(2-chloroethyl)amino-(2-chloroethoxy)phosphoryl]amino]propan-1-ol Phosphorodiamidic acid, N,N-bis(2-chloroethyl)-N'-(3-hydroxypropyl)-, 2-chloroethyl ester 3733-81-1 C9H20Cl3N2O3P