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MK-677

MK-677 Structure
MK-677 structure
CAS No.
159634-47-6
Chemical Name:
MK-677
Synonyms
MK-677;Ibutamoren;Mk677 Sarms;IbutaMoren (MK-677);L 163191;MK-0677;MK-677;IBUTAMOREN (MK-677), CID178024;MK-677?/?Ibutamoren 10mg Tablets;Ibutamoren,MK-677, MK-0677, L-163,191;Ibutamoren mesylate (MK-0667, L163191);(R)-2-amino-N-(3-(benzyloxy)-1-(1-(methylsulfonyl)spiro[indoline-3,4'-piperidin]-1'-yl)-1-oxopropan-2-yl)-2-methylpropanamide
CBNumber:
CB31178916
Molecular Formula:
C27H36N4O5S
Molecular Weight:
528.66
MDL Number:
MFCD00867473
MOL File:
159634-47-6.mol
MSDS File:
SDS
Last updated:2024-11-11 17:44:06
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MK-677 Properties

Density 1.32
pka 15.73±0.46(Predicted)
InChIKey UMUPQWIGCOZEOY-JOCHJYFZSA-N
SMILES C(N[C@H](COCC1=CC=CC=C1)C(N1CCC2(CC1)C1=C(N(S(C)(=O)=O)C2)C=CC=C1)=O)(=O)C(N)(C)C
FDA UNII GJ0EGN38UL

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P264-P270-P301+P310-P321-P330-P405-P501

MK-677 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation API0014019 MK-677 HYDROCHLORIDE 95.00% 159634-47-6 5MG $498.05 2021-12-16 Buy
Product number Packaging Price Buy
API0014019 5MG $498.05 Buy

MK-677 Chemical Properties,Uses,Production

Description

Ibutamoren (INN) (developmental code names MK-677, MK-0677, L-163,191)is a non-peptidic, potent, long acting, orally-active, and selective agonist of the ghrelin receptor and a growth hormone secretagogue, mimicking the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin.
It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including GH and insulin-like growth factor 1 (IGF-1), but without affecting cortisol levels. MK677 has shown to sustain activation of GH-IGF-1 Axis and increase in lean body mass but no change in total fat mass or visceral fat.
It is currently under development as a potential treatment for reduced levels of these hormones, such as in children or elderly adults with growth hormone deficiency, and human studies have shown it to increase both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty in the elderly.

Uses

Growth hormone releasing factor.

benefits

The benefits of MK-677 include muscle-building, a reduction in muscle wasting, better bone density, improved sleep, and anti-aging properties. It may also have nootropic effects and it can be beneficial in treating growth hormone deficiencies. 

Side effects

Side effects of MK-677 are typically the result of unnaturally high levels of growth hormone in the body from taking too much too often, which include:
Increased appetite
Lethargy
Joint pain if you have previous medical conditions or elevated hormone levels
Insulin resistance
Possible increase in prolactin levels. 

Safety

Ibutamoren is a muscle building anabolic compound. It's considered safe if you don't have high blood glucose level and if you don't suffer from congestive heart failure. It's considered a boon for anti aging and it's a life longevity material. It's considered to be more beneficial than to be harmful. The optimal dose for body building is to take 25mg at bedtime for four to six weeks. It is a water retaining compound so beware of bloating.

MK-677 synthesis

10314-98-4
159634-47-6
Synthesis of MK-677 from 1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid

MK-677 Preparation Products And Raw materials

Raw materials

Spiro[3H-indole-3,4'-piperidine], 1'-[(2R)-2-amino-1-oxo-3-(phenylmethoxy)propyl]-1,2-dihydro-1-(methylsulfonyl)- Spiro[3H-indole-3,4'-piperidine]-1'-carboxylic acid, 1,2-dihydro-1-(methylsulfonyl)-, phenylmethyl ester (R)-tert-butyl (3-(benzyloxy)-1-(1-(methylsulfonyl)spiro[indoline-3,4'-piperidin]-1'-yl)-1-oxopropan-2-yl)carbamate Benzyl 4-(chlorocarbonyl)tetrahydro-1(2H)-pyridinecarboxylate 1-(methylsulfonyl)spiro[indoline-3,4'-piperidine]
MK677 benzyl spiro[indole-3,4'-piperidine]-1'-carboxylate 1'-(BENZYLOXYCARBONYL)SPIRO(INDOLINE-3,4'-PIPERIDINE) 4-FORMYL-N-CBZ-PIPERIDINE 1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid
Boc-D-Ser(Bzl)-OH Isonipecotic acid Phenylhydrazine Benzyl bromide

1of3

Preparation Products

MK-677 Suppliers

Global( 57)Suppliers
Supplier Tel Email Country ProdList Advantage
Wuhan Cell Pharmaceutical Co., Ltd 		+86-13129979210 +86-13129979210 sales@cellwh.com China 376 58
Nantong Guangyuan Chemicl Co,Ltd 		+undefined17712220823 admin@guyunchem.com China 615 58
zhuzhou dingcheng meihei comestic co.,ltd 		+8618873369619 dingchengbusiness8@163.com China 260 58
ARCTIC EXPORTS INC 		+1-3026880818 +1-3026880818 ARCTICEXPORTSINC@GMAIL.COM Canada 66 58
Shandong Huizhihan Supply Chain Co., Ltd 		+8613363081709 3957328362@qq.com China 300 58
Hangzhou FandaChem Co.,Ltd. 		+8615858145714 FandaChem@Gmail.com China 8946 55
Nanjing Finetech Chemical Co., Ltd. 		025-85710122 17714198479 sales@fine-chemtech.com CHINA 885 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29880 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
Zhengzhou Alfa Chemical Co.,Ltd 		+8618530059196 sale04@alfachem.cn China 11885 58
Supplier Advantage
Wuhan Cell Pharmaceutical Co., Ltd 		58
Nantong Guangyuan Chemicl Co,Ltd 		58
zhuzhou dingcheng meihei comestic co.,ltd 		58
ARCTIC EXPORTS INC 		58
Shandong Huizhihan Supply Chain Co., Ltd 		58
Hangzhou FandaChem Co.,Ltd. 		55
Nanjing Finetech Chemical Co., Ltd. 		55
career henan chemical co 		58
Chongqing Chemdad Co., Ltd 		58
Zhengzhou Alfa Chemical Co.,Ltd 		58

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View Lastest Price from MK-677 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ibutamoren pictures 2024-12-27 Ibutamoren
159634-47-6
 US $30.00 / kg 1kg 99% 10000kg hebei hongtan Biotechnology Co., Ltd
MK-677/Ibutamoren pictures 2024-12-23 MK-677/Ibutamoren
159634-47-6
 US $0.00-0.00 / Bottle 1Bottle 99% 2000 Shandong Huizhihan Supply Chain Co., Ltd
MK-677/Ibutamoren 10mg Tablets pictures 2024-12-23 MK-677/Ibutamoren 10mg Tablets
159634-47-6
 US $0.00-0.00 / Bottle 1Bottle 99% 2000 Shandong Huizhihan Supply Chain Co., Ltd
  • Ibutamoren pictures
  • Ibutamoren
    159634-47-6
  • US $30.00 / kg
  • 99%
  • hebei hongtan Biotechnology Co., Ltd
  • MK-677/Ibutamoren pictures
  • MK-677/Ibutamoren
    159634-47-6
  • US $0.00-0.00 / Bottle
  • 99%
  • Shandong Huizhihan Supply Chain Co., Ltd

MK-677 Spectrum

MK-677(159634-47-6)1HNMR
2-Amino-N-[(1R)-2-[1,2-dihydro-1-(methylsulfonyl)spiro[3H-indole-3,4'-piperidin]-1'-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methylpropanamide IbutaMoren (MK-677) Ibutamoren 2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide IBUTAMOREN (MK-677), CID178024 Ibutamoren,MK-677, MK-0677, L-163,191 L 163191;MK-0677;MK-677 (R)-2-amino-N-(3-(benzyloxy)-1-(1-(methylsulfonyl)spiro[indoline-3,4'-piperidin]-1'-yl)-1-oxopropan-2-yl)-2-methylpropanamide Ibutamoren mesylate (MK-0667, L163191) Propanamide, 2-amino-N-[(1R)-2-[1,2-dihydro-1-(methylsulfonyl)spiro[3H-indole-3,4'-piperidin]-1'-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methyl- Mk677 Sarms 159634-47-6 (R)-2-amino-N-(3-(benzyloxy)-1-(1-(methylsulfonyl)spiro[indoline-3,4'-piperidin]-1'-yl)-1-oxopropan-2-yl)-2-methylpropanamide MK-677 MK-677?/?Ibutamoren 10mg Tablets (R)-2-amino-N-(3-(benzyloxy)-1-(1-(methylsulfonyl)spiro[indoline-3,4'-piperidin]-1'-yl)-1-oxopropan-2-yl)-2-methylpropanamide 159634-47-6 C27H36N4O5S