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4-Chloro-4'-fluorobutyrophenone

4-Chloro-4'-fluorobutyrophenone structure

CAS No.: 3874-54-2

Chemical Name:: 4-Chloro-4'-fluorobutyrophenone

Synonyms: 4-CHLORO-4-FLUOROBUTYROPHENONE;NSC 87082;LUMAT-009;JACS-3874-54-2;AKOS BBS-00006481;uorobutyrophenone;TIMTEC-BB SBB003536;4-Chloro-4'-fluorobu;Haloperidol Impurity 1;Haloperidol Impurity 21

CBNumber:: CB3118281

Molecular Formula:: C10H10ClFO

Molecular Weight:: 200.64

MDL Number:: MFCD00001007

MOL File:: 3874-54-2.mol

MSDS File:: SDS

Last updated:2024-09-02 11:34:00

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4-Chloro-4'-fluorobutyrophenone Properties

Melting point	5-6 °C
Boiling point	130-132 °C (0.97513 mmHg)
Density	1.22 g/mL at 25 °C(lit.)
refractive index	n20/D 1.5255(lit.)
Flash point	>230 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Slightly)
form	Oil
color	Slightly yellow-greenish clear
PH	4.05 at 23.1℃ and 10g/L
Water Solubility	0.38 g/L (20 ºC)
BRN	608741
InChIKey	HXAOUYGZEOZTJO-UHFFFAOYSA-N
LogP	2.84 at 30℃
CAS DataBase Reference	3874-54-2(CAS DataBase Reference)
FDA UNII	FVL03C7JRR
NIST Chemistry Reference	1-Butanone, 4-chloro-1-(4-fluorophenyl)-(3874-54-2)
EPA Substance Registry System	1-Butanone, 4-chloro-1-(4-fluorophenyl)- (3874-54-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312a-P330-P501a

Hazard Codes

Xn,Xi

Risk Statements

22-36/37/38-20/21/22

Safety Statements

24/25-36-26

WGK Germany

Hazard Note

Irritant

TSCA

Yes

HS Code

2914790090

NFPA 704

	1
2		0

4-Chloro-4'-fluorobutyrophenone price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C43609	4-Chloro-4′-fluorobutyrophenone 97%	3874-54-2	25g	$54.3	2024-03-01	Buy
Sigma-Aldrich	C43609	4-Chloro-4′-fluorobutyrophenone 97%	3874-54-2	100g	$138	2023-06-20	Buy
TCI Chemical	C1294	4-Chloro-4'-fluorobutyrophenone >97.0%(GC)	3874-54-2	25g	$44	2024-03-01	Buy
Alfa Aesar	A11121	4-Chloro-4'-fluorobutyrophenone, 96%	3874-54-2	25g	$22.9	2021-12-16	Buy
Alfa Aesar	A11121	4-Chloro-4'-fluorobutyrophenone, 96%	3874-54-2	100g	$59	2021-12-16	Buy

Product number	Packaging	Price	Buy
C43609	25g	$54.3	Buy
C43609	100g	$138	Buy
C1294	25g	$44	Buy
A11121	25g	$22.9	Buy
A11121	100g	$59	Buy

4-Chloro-4'-fluorobutyrophenone Chemical Properties,Uses,Production

Chemical Properties

slightly yellow-greenish clear oil

Uses

4-Chloro-4''-fluorobutyrophenone (cas# 3874-54-2) is a compound useful in organic synthesis.

Uses

4-Chloro-4‘-fluorobutyrophenone is a pharmaceutical intermediate compound suitable for the production of antipsychotics and active pharmaceutical ingredients (APIs) for the treatment of depression.4-Chloro-4’-fluorobutyrophenone can be used as a synthesis of trifluprednis, azaperone, melperone, Melperone, Timiperone, Bromoperidol, Haloperidol, Benzoperidol, Droperidol, Fluanisone and other APIs as pharmaceutical intermediates.

Synthesis

The purified alkyne (5 mmol) was treated with a solution of HNTf2 (60-200 mol %) in 1,4-dioxane in apreheated oil bath at 100°C, under magnetic stirring, for 18-52 h, and the corresponding ketone was purified by column chromatography after cooling 4-Chloro-4'-fluorobutyrophenone. The reaction crude was purified by column chromatography using 20% AcOEt in n-hexane as an eluent. Isolated yield: 850 mg (85%). R f (20% AcOEt in n-hexane): 0.66. GC-MS (m/ z, M+? 200), major peaks found: 200 (1%), 164 (1%), 138 (43%), 123 (100%), 107 (10%). 1H NMR (δ, ppm; J, Hz): 8.03-7.97 (2C-H arom, mult), 7.17-7.09 (2C-H arom, mult), 3.68 (CH2, t, J = 6.2), 3.15 (CH2, t, J = 7.0), 2.22 (CH2, tt, J = 7.0, 6.2). 13C NMR (δ, ppm; J, Hz): 197.3 (C=O), 166.1 (C, d, J 1 C-F = 254.7), 133.2 (C, d, J 4 C-F = 4.3), 130.6 (2CH, d, J 3 C-F = 9.3), 115.9 (2CH, d, J 2 C-F = 22.2), 44.6 (CH2), 35.2 (CH2), 26.7 (CH2).
4-Chloro-4'-fluorobutyrophenone synthesis

4-Chloro-4'-fluorobutyrophenone synthesis

Synthesis of 4-Chloro-4'-fluorobutyrophenone from Fluorobenzene and 4-Chlorobutyryl chloride

4-Chloro-4'-fluorobutyrophenone Preparation Products And Raw materials

Raw materials

Preparation Products

ITI-722 Cyclopropyl 4-fluorophenyl ketone Ciproxifan

4-Chloro-4'-fluorobutyrophenone Suppliers

Global( 409)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Famo Biotech Co Ltd	+86-36680037 +86-18550473860	mayan@famobiotech.com;sales@famobiotech.com	China	528	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-81138252 +86-18789408387	1057@dideu.com	China	3958	58
Dorne Chemical Technology co. LTD	+86-86-13583358881 +8618560316533	Ethan@dornechem.com	China	3096	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20287	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18777	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
Zjartschem	+86-571 87238903	jocelynpan@zjarts.com	CHINA	988	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29882	58

Supplier	Advantage
Shanghai Famo Biotech Co Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
Dorne Chemical Technology co. LTD	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
Zjartschem	58
career henan chemical co	58

View Lastest Price from 4-Chloro-4'-fluorobutyrophenone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-25	4-Chloro-4'-fluorobutyrophenone 3874-54-2	US $10.00 / ASSAYS	1ASSAYS	99%	10 ton	Dorne Chemical Technology co. LTD
2024-08-14	4-Chloro-4'-fluorobutyrophenone 3874-54-2	US $1.00 / KG	1KG	99%	20T	Shaanxi Dideu Medichem Co. Ltd
2024-07-06	4-Chloro-4'-fluorobutyrophenone 3874-54-2	US $0.00 / kg	1kg	0.99	10T	Shandong Hanjiang Chemical Co., Ltd

4-Chloro-4'-fluorobutyrophenone
3874-54-2
US $10.00 / ASSAYS
99%
Dorne Chemical Technology co. LTD

4-Chloro-4'-fluorobutyrophenone
3874-54-2
US $1.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

4-Chloro-4'-fluorobutyrophenone
3874-54-2
US $0.00 / kg
0.99
Shandong Hanjiang Chemical Co., Ltd

4-Chloro-4'-fluorobutyrophenone Spectrum

4-Chloro-4'-fluorobutyrophenone(3874-54-2)MS 4-Chloro-4'-fluorobutyrophenone(3874-54-2)¹HNMR 4-Chloro-4'-fluorobutyrophenone(3874-54-2)¹³CNMR 4-Chloro-4'-fluorobutyrophenone(3874-54-2)IR1 4-Chloro-4'-fluorobutyrophenone(3874-54-2)Raman

3874-54-2(4-Chloro-4'-fluorobutyrophenone)Related Search:

4-Fluorobenzaldehyde 2-Butanone oxime Epichlorohydrin 4-Methyl-2-pentanone Transfluthrin

Florfenicol N-(4'-fluorobutyrophenone)-4-(4-chlorophenyl)pyridinium HALOPERIDOL RELATED COMPOUND A (15 MG) (4,4'-BIS[(4-P-CHLOROPHENYL)-4-HYDROXY-PIPERIDINO]-BU-TYROPHENONE) 3-CHLORO-4'-FLUOROPROPIOPHENONE 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(3-ethyl-4-fluorophenyl)-1-butanone

Haloperidol EP Impurity E GUTXTARXLVFHDK-GIVHGBEGSA-N 4-[4-(4-chloro-2,3,5,6-tetradeuteriophenyl)-4-hydroxy-1-oxidopiperidin-1-ium-1-yl]-1-(4-fluorophenyl)butan-1-one Dechloro Haloperidol (Haloperidol Impurity B) Cyclopropyl 4-fluorophenyl ketone

Haloperidol EP Impurity F 4-CHLORO-1-(2-FLUOROPHENYL)-1-OXOBUTANE 1-(4-FLUOROPHENYL)-4-HYDROXYBUTAN-1-ONE

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3-CHLOROPROPYL4-FLUOROPHENYLKETONE/4-CHLORO-4''-FLUOROBUTYROPHENONE 1-Butanone, 4-chloro-1-(4-fluorophenyl)- 1-(4-Fluorophenyl)-4-chloro-1-butanone γ-Chloro-4'-fluorobutyrophenone ω-Chloro-4'-fluorobutyrophenone Chloro-4'-fluorobutyrophe 4-Chloro-4'-fluorobu 4-chloro-4-fluorophenyl ketone 1-Chloro-4-(4-fluorophenyl)-4-oxobutane 3-(4-Fluorophenylcarbonyl)-1-chloropropane NSC 87082 4-Chloro-4'-fluoro-butyrophenone (OR) 3-(4-Fluorobenzoyl)propyl chloride 3-(p-Fluorobenzoyl)propyl chloride GAMMA-CHLORO-4-FLUOROBUTYROPHENONE GAMMA-CHLORO-P-FLUOROBUTYROPHENONE G-CHLORO-P-FLUOROBUTYROPHENONE AKOS BBS-00006481 4-CHLORO-1-(4-FLUOROPHENYL)-1-BUTANONE 4-CHLORO-1-(4-FLUOROPHENYL)-1-OXOBUTANE 4-CHLORO-4'-FLUOROBUTYROPHENONE 3-CHLOROPROPYL 4-FLUOROPHENYL KETONE TIMTEC-BB SBB003536 3-Chloro-4'-fluorobutyrophenone 4-(4-Fluorophenyl)-4-oxobutyl chloride 4-(p-Fluorophenyl)-4-oxobutyl chloride 4-chloro-1-(4-fluorophenyl)-1-butanon 4-Chloro-p-fluorobutyrophenone 4-Fluorobenzoylpropyl chloride Butyrophenone, 4-chloro-4'-fluoro- omega-Chloro-4-fluorobutyrophenone omega-Chloro-p-fluorobutyrophenone p-Fluoro-4-chlorobutyrophenone p-Fluorobenzoylpropyl chloride p-Fluoro-gamma-chlorobutyrophenone p-Fluoro-omega-chlorobutyrophenone Chloropfluorobutyrophenone OMEGA-CHLORO-4-FLUOROBUTYROPHENONE 97& 4-Chloro-4'-fluorobutyrophenone 97% 4-Chloro-4'-fluorobutyrophenone97% 4-CHLORO-4"-FLUOROBURYROPHENONE LUMAT-009 4-Cloro-4'-fluorobutirrofenone 4-CHLORO-4'-FLUOROBUTYROPHENONE BATCH NO: CFKT-10923/0319/FP/001 4-Chloro-4’-fluoro-butyrophenone (OR) 3-Chloropropyl-4-fluorophenyl ketone JACS-3874-54-2 4-Chloro-4'-fluorobutyrophenone > uorobutyrophenone Haloperidol Impurity 1 Haloperidol Decanoate Impurity 17 99% Purity 4-Chloro-4'-fluorobutyrophenone High Quality 4-Chloro-4'-fluorobutyrophenone 4-chloro-4 '-flubutanone 4-Chloro-4'Fluorobutyrophenone (FBP) 4-Chloro-4'-fluoroacetophenone 4-CHLORO-4-FLUOROBUTYROPHENONE Azaperone,Droperidol, Haloperidole,Timiperone 4-Chloro-4'-fluorobutyrophenone