![](/CAS/GIF/3874-54-2.gif)
4-Chloro-4'-fluorobutyrophenone synthesis
- Product Name:4-Chloro-4'-fluorobutyrophenone
- CAS Number:3874-54-2
- Molecular formula:C10H10ClFO
- Molecular Weight:200.64
![4-Chloro-4'-fluorobutyrophenone synthesis 4-Chloro-4'-fluorobutyrophenone synthesis](/NewsImg/2023-06-01/6382123277755855604044069.png)
![Fluorobenzene](/CAS/GIF/462-06-6.gif)
462-06-6
408 suppliers
$10.00/5g
![4-Chlorobutyryl chloride](/CAS/GIF/4635-59-0.gif)
4635-59-0
465 suppliers
$17.67/10gm:
![4-Chloro-4'-fluorobutyrophenone](/CAS/GIF/3874-54-2.gif)
3874-54-2
368 suppliers
$10.00/5G
Yield:3874-54-2 90%
Reaction Conditions:
with aluminum (III) chloride in dichloromethane at 20; for 4 h;Time;
Steps:
1-2
Mix 16 g of fluorobenzene and 20 g of dichloromethane to obtain a fluorobenzene dichloromethane solution (the temperature of the ice bath is guaranteed to be 5°C);After mixing 20g 4-chlorobutyryl chloride and 20g dichloromethane fourth,Obtain a mixed solution of 4-chlorobutyryl chloride and dichloromethane;The mixture of 4-chlorobutyryl chloride and dichloromethane was added dropwise to the fluorobenzene dichloromethane solution at a drip rate of 70 drops/min and mixed with 20 g of anhydrous aluminum chloride, and the second substitution was carried out at 20°C. Reaction for 4h; after the completion of the second substitution reaction, the product of the second substitution reaction is transferred to 600g of ice water for quenching reaction at a speed of 200r/min for 0.3h; the product after the quenching reaction is liquid-separated; The organic phase obtained from the liquid was mixed with 4g of anhydrous sodium sulfate to remove water, then filtered and concentrated (50°C),Obtain 4-chloro-1-(4-fluorophenyl)butan-1-one (with a yield of 90% and a purity of 99%);
References:
CN112538042,2021,A Location in patent:Paragraph 0089; 0095; 0098; 0104
![1-(4-Chlorobut-1-yn-1-yl)-4-fluorobenzene](/CAS/20200611/GIF/1183278-95-6.gif)
1183278-95-6
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![4-Chloro-4'-fluorobutyrophenone](/CAS/GIF/3874-54-2.gif)
3874-54-2
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339365-53-6
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![4-Chloro-4'-fluorobutyrophenone](/CAS/GIF/3874-54-2.gif)
3874-54-2
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![2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane](/CAS/GIF/3308-94-9.gif)
3308-94-9
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$35.00/1g
![4-Chloro-4'-fluorobutyrophenone](/CAS/GIF/3874-54-2.gif)
3874-54-2
368 suppliers
$10.00/5G