ChemicalBook CAS DataBase List 4-Methyl-2-pentanone

4-Methyl-2-pentanone synthesis

13synthesis methods

Product Name:4-Methyl-2-pentanone
CAS Number:108-10-1
Molecular formula:C6H12O
Molecular Weight:100.16

By hydrogenation of mesityl oxide over Ni at 160 to 190°C; also by oxidation of methyl isobutyl carbinol.

2035-08-7 Synthesis

2-Methyl-2-(2-methylpropyl)-1,3-dioxolane

2035-08-7
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108-10-1
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Yield:108-10-1 99%

Reaction Conditions:

with chloral hydrate in hexane at 25; for 0.5 h;Inert atmosphere;

Steps:

3

General procedure: A stirred solution of the acetal (2, 3.5 mmol) in dry hexane (5 ml), under dry nitrogen at 25 C, was treated with 1 (1.7 g, 10.6 mmol). The mixture was stirred for 2 h, treated with water, and extracted with dichloromethane (10 ml). The extracts were washed with brine solution, dried (Na2SO4), and concentrated in vacuo. The resulting residue was purified by column chromatography on neutral alumina(50-325 mesh, eluent: 2.5:97.5 ethyl acetate-hexane), to obtain the corresponding carbonyl compound (3). The purity was estimated to be >98% by 1H and 13C NMRspectroscopic analysis. In the case of solid acetals, 0.5 ml of dichloromethane along with hexane was added for added solubility; in the case of thioacetals, 21.2 mmol of 1 was used fo reffective deprotection

References:

Chandrasekhar, Sosale;Shrinidhi, Annadka [Synthetic Communications,2014,vol. 44,# 13,p. 1904 - 1913]