ChemicalBook >> CAS DataBase List >>Gestrinone
Gestrinone
- CAS No.
- 16320-04-0
- Chemical Name:
- Gestrinone
- Synonyms
- ru2323;r-2323;A-46745;Dimetrose;NeMestran;TridoMose;gestrigone;GESTRINONE;Dimetriose;gestinone.
- CBNumber:
- CB3121391
- Molecular Formula:
- C21H24O2
- Molecular Weight:
- 308.41
- MDL Number:
- MFCD00865561
- MOL File:
- 16320-04-0.mol
- MSDS File:
- SDS
Last updated:2024-07-02 08:55:04
| Melting point | 150-152°C |
|---|---|
| alpha | D20 +84.6° (c = 0.41 in methanol) |
| Boiling point | 388.8°C (rough estimate) |
| Density | 1.1040 (rough estimate) |
| refractive index | 1.4900 (estimate) |
| storage temp. | -20°C Freezer |
| solubility |
DMF:20.0(Max Conc. mg/mL);64.85(Max Conc. mM) DMSO:35.0(Max Conc. mg/mL);113.48(Max Conc. mM) Ethanol:20.0(Max Conc. mg/mL);64.85(Max Conc. mM) Ethanol:PBS (pH 7.2) (1:5):0.25(Max Conc. mg/mL);81.06(Max Conc. mM) Water:1.0(Max Conc. mg/mL);3.24(Max Conc. mM) |
| form | A crystalline solid |
| pka | 12.76±0.40(Predicted) |
| color | Off-white to light yellow |
| Merck | 14,4415 |
| Stability | Hygroscopic |
| InChI | InChI=1S/C21H24O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,9,11,13,18-19,23H,3,5-8,10,12H2,1H3/t18-,19+,20+,21+/m1/s1 |
| InChIKey | BJJXHLWLUDYTGC-ANULTFPQSA-N |
| SMILES | C1C2C(CC[C@]3([H])C=2C=C[C@@]2(CC)[C@@]3([H])CC[C@]2(C#C)O)=CC(=O)C1 |
| CAS DataBase Reference | 16320-04-0(CAS DataBase Reference) |
| FDA UNII | 1421533RCM |
| ATC code | G03XA02 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H360-H362 |
| Precautionary statements | P201-P260-P263-P264-P270-P308+P313 |
| RTECS | JF7964000 |
| Toxicity | mouse,LDLo,intraperitoneal,1gm/kg (1000mg/kg),BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)GASTROINTESTINAL: OTHER CHANGES,Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 701, 1988. |
Gestrinone price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10006488 | Gestrinone ≥98% | 16320-04-0 | 100mg | $110 | 2024-03-01 | Buy |
| Cayman Chemical | 10006488 | Gestrinone ≥98% | 16320-04-0 | 500mg | $459 | 2024-03-01 | Buy |
| Cayman Chemical | 10006488 | Gestrinone | 16320-04-0 | 1000mg | $864 | 2024-03-01 | Buy |
| Chem-Impex | 37917 | Gestrinone,≥98%(AssaybyTitration) ≥98%(AssaybyTitration) | 16320-04-0 | 100MG | $292.36 | 2021-12-16 | Buy |
| AvaChem | 3789 | Gestrinone | 16320-04-0 | 100mg | $390 | 2021-12-16 | Buy |
Gestrinone Chemical Properties,Uses,Production
Description
Gestrinone is a synthetic steroid with antiprogesterone and antiestrogenic activities. It is reported to be useful in the treatment of endometriosis and uterine leiom yomas.
Chemical Properties
Light Yellow Solid
Originator
Roussel UCLAF (France)
Uses
Steroidal antiestrogen, antiprogestogen, analog of Norgestrienone. Antigonadotropin. Controlled substance.
Definition
ChEBI: Gestrinone is an oxo steroid.
brand name
DIMETROSE
Side effects
Gestrinone, like danazol, inhibits the synthesis of estrogens and progestogens and has been used mainly to prepare patients with an endometrial disorder for hysterectomy. Its most common adverse effects are nausea, headache, mood changes, rash, hot flushes, weight gain, and discomfort in the joints and muscles. In some cases, there is evidence of masculinization.
Mode of action
The primary action of gestrinone is on the hypothalamic-pituitary axis, where it inhibits gonadotrophin release with a weak inhibitory effect on its synthesis. It also possesses anti-estrogen activity. The mode of action of gestrinone used for EC is probably inhibition of implantation by acting on the endometrium rather than inhibiting ovulation[1].
References
[1] Xuefeng Gao, Guian Chen, Erruo Wu . “Mechanism of emergency contraception with gestrinone: a preliminary investigation.” Contraception 76 3 (2007): Pages 221-227.
Gestrinone Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Global( 103)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Liaoning Pharmaceutical Innovation Co., Ltd | +8616588669988 | sales@pipharma.com.cn | China | 151 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 615 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Hubei XinRunde Chemical Co., Ltd. | +8615102730682 | bruce@xrdchem.cn | CHINA | 566 | 55 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8618959220845 | sales@amoychem.com | China | 6383 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| Nanjing Shizhou Biotechnology Co., Ltd | +86-15850508050 +86-15850508050 | sean.lv@synzest.com | China | 323 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30240 | 58 |
View Lastest Price from Gestrinone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-09-25 | Gestrinone
16320-04-0
|
US $0.00 / kg | 1kg | 99% | 100kg | Wuhan Senwayer Century Chemical Co.,Ltd | |
 |
2024-03-08 | Gestrinone
16320-04-0
|
US $10.00 / kg | 1kg | 99% | 1000kg | Nantong Guangyuan Chemicl Co,Ltd | |
 |
2021-07-02 | Gestrinone
16320-04-0
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Gestrinone
16320-04-0
- US $0.00 / kg
- 99%
- Wuhan Senwayer Century Chemical Co.,Ltd
-
- Gestrinone
16320-04-0
- US $10.00 / kg
- 99%
- Nantong Guangyuan Chemicl Co,Ltd
-
- Gestrinone
16320-04-0
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
16320-04-0(Gestrinone)Related Search:
(8s,13s,14s,17r)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
13-ETHYL-17ALPHA-HYDROXY-18,19-DINORPREGNA-4,9,11-TRIEN-20-YN-3-ONE
D-GESTRINONE
GESTRINONE
9,11-trien-20-yn-3-one,13-ethyl-17-hydroxy-19-dinorpregna-(17-alpha)-1
ethylnorgestrienone
gestrigone
r-2323
ru2323
13-beta-ethyl-17-alpha-ethinyl-17-hydroxy-gona-4,9,11-triene-3-one
13-ethyl-17-alpha-ethinyl-17-hydroxygon-4,9,11-trien-3-one
13-Ethyl-17α-ethynyl-17-hydroxy-4，9，11-gonatrien-3-one
A-46745
Dimetriose
Dimetrose
Nemestran：Tridomose
(17α)-13-Ethyl-17-hydroxy-18,19-dinorpregna-4,9,11-trien-20-yn-3-one
13-Ethyl-17α-ethynyl-17β-hydroxygona-4,9,11-trien-3-one
NeMestran
TridoMose
Gestrinone
(8S,13S,14S,17R)-13-Ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
13-ethyl-17-hydroxy-18,19-dinor-17-alpha-pregna-4,9,11-trien-20-yn-3-one
19-dinor-17-alpha-pregna-4,9,11-trien-20-yn-3-one,13-ethyl-17-hydroxy-1
13-Ethyl-17-alpha-ethynyl-17-hydroxygon-4,9,11-trien-3-one
Gestrinone 99%min Dimetriose
CAS16320-04-0 Gestrinone 99%min Dimetriose
Gestrinone USP/EP/BP
18,19-Dinorpregna-4,9,11-trien-20-yn-3-one, 13-ethyl-17-hydroxy-, (17α)-
Gestrinone (1.0mg/ml in Acetonitrile)
4, 9, 11-ESTRATRIEN-17α-ETHYLNY-18-HOMO-17β-OL-3-ONE
gestinone.
16320-04-0
C21H24O2
Hormone
Active Pharmaceutical Ingredients
Intermediates & Fine Chemicals
Pharmaceuticals
Steroids