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brusatol

brusatol structure

CAS No.: 14907-98-3

Chemical Name:: brusatol

Synonyms: 100935;Brustaol;Yatansin;Brusato1;NSC 172924;(+)-Brusatol;Brusatol - Bio-X ?;Brusatol >=95% (HPLC);Brusatol (NSC 172924);Brusatol, 10 mM in DMSO

CBNumber:: CB31342731

Molecular Formula:: C26H32O11

Molecular Weight:: 520.53

MDL Number:: MFCD01746220

MOL File:: 14907-98-3.mol

MSDS File:: SDS

Last updated:2025-04-17 18:22:24

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brusatol Properties

Boiling point	724.3±60.0 °C(Predicted)
Density	1.46±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.	-20°C
solubility	DMF: 1 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
pka	8.81±0.70(Predicted)
form	powder
color	white to beige
optical activity	[α]/D +35 to +44°, c = 0.5 in acetone
biological source	(Brucia javanica)
LogP	0.393 (est)
FDA UNII	3ATY6SZ64B
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338

brusatol price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML1868	Brusatol ≥95% (HPLC)	14907-98-3	5MG	$105	2024-03-01	Buy
Sigma-Aldrich	SML1868	Brusatol ≥95% (HPLC)	14907-98-3	25MG	$424	2024-03-01	Buy
TRC	B701056	(+)-Brusatol	14907-98-3	5mg	$315	2021-12-16	Buy
Biosynth Carbosynth	FB30016	Brusatol	14907-98-3	5mg	$100	2021-12-16	Buy
ChemScene	CS-W019658	Brusatol 99.89%	14907-98-3	10mg	$280	2021-12-16	Buy

Product number	Packaging	Price	Buy
SML1868	5MG	$105	Buy
SML1868	25MG	$424	Buy
B701056	5mg	$315	Buy
FB30016	5mg	$100	Buy
CS-W019658	10mg	$280	Buy

brusatol Chemical Properties,Uses,Production

Uses

Brusatol has been used to study the protective role of Nrf2 (nuclear factor, erythroid 2 like 2 ) in intestinal ischemia/reperfusion induced injury.

Definition

ChEBI: Brusatol is a triterpenoid.

Biochem/physiol Actions

Brusatol promotes Nrf2 (nuclear factor, erythroid 2 like 2 ) ubiquitination and degradation. Brusatol upregulates the expression of multiple ribosomal components and controls macromolecular complex function.

in vivo

Brusatol is able to reach the tumor tissue and inhibit the Nrf2 pathway. Nude mice are injected with A549 cells to induce tumor growth, followed by a single i.p. injection of 2 mg/kg Brusatol. Nrf2 protein levels are significantly decreased at 24 h or 48 h postinjection^[1].
Cisplatin (2 mg/kg) or Brusatol (2 mg/kg) alone does not inhibit tumor growth significantly, whereas in the combination group, tumor size is significantly reduced^[1]. "

Animal Model:	Athymic nude mice 4-6 wk old bearing A549 xenografts^[1]
Dosage:	2 mg/kg
Administration:	Treated i.p.; Cisplatin (2 mg/kg), Brusatol (2 mg/kg), or in combination every other day for a total of five times
Result:	Nrf2 protein levels were significantly decreased at 24 h or 48 h postinjection. Cisplatin or Brusatol alone did not inhibit tumor growth significantly, whereas in the combination group, tumor size was significantly reduced.?"

brusatol Preparation Products And Raw materials

Raw materials

Preparation Products

brusatol Suppliers

Global( 154)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	scglp@glp-china.com	CHINA	1824	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20235	58
Chengdu Greenpure Biopharma CO.,Ltd	18283602253; +8618283602253	jancyzheng@gcgreenpure.com	China	953	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29858	58
Chengdu Biopurify Phytochemicals Ltd.	+86-28-82633860; +8618080483897	sales@biopurify.com	China	3772	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Wuhan ChemNorm Biotech Co.,Ltd.	+86-27-8439 4403 18971486879	sales@chemnorm.com	CHINA	2935	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10244	58
Aktin Chemicals, Inc.	028-85159085	info@aktinchem.com	CHINA	1025	58

Supplier	Advantage
Chengdu GLP biotechnology Co Ltd	58
Henan Fengda Chemical Co., Ltd	58
Chengdu Greenpure Biopharma CO.,Ltd	58
career henan chemical co	58
Chengdu Biopurify Phytochemicals Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
BOC Sciences	58
Wuhan ChemNorm Biotech Co.,Ltd.	58
Hubei Ipure Biology Co., Ltd	58
Aktin Chemicals, Inc.	58

View Lastest Price from brusatol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-19	Brusatol 14907-98-3	US $60.00-217.00 / mg		99.82%	10g	TargetMol Chemicals Inc.
2024-04-08	brusatol 14907-98-3	US $8.00-0.80 / kg	1kg	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2019-07-06	brusatol 14907-98-3	US $1.00 / KG	1g	99%	100KG	Career Henan Chemical Co

Brusatol
14907-98-3
US $60.00-217.00 / mg
99.82%
TargetMol Chemicals Inc.

brusatol
14907-98-3
US $8.00-0.80 / kg
99%
Henan Fengda Chemical Co., Ltd

brusatol
14907-98-3
US $1.00 / KG
99%
Career Henan Chemical Co

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13,20-Epoxy-3,11β,12α-trihydroxy-15β-[(3-methyl-1-oxo-2-butenyl)oxy]-2,16-dioxopicras-3-en-21-oic acid methyl ester 13,20-Epoxy-3,11β,12α-trihydroxy-15β-[(3-methyl-1-oxo-2-butenyl)oxy]-2,16-dioxopicrasa-3-ene-21-oic acid methyl ester Picras-3-en-21-oicacid,13,20-epoxy-3,11,12-trihydroxy-15-[(3-Methyl-1-oxo-2-buten-1-yl)oxy]-2,16-dioxo-,Methyl ester, (11b,12a,15b)- NSC 172924 Yatansin Picras-3-en-21-oic acid, 13,20-epoxy-3,11,12-trihydroxy-15-[(3-methyl-1-oxo-2-buten-1-yl)oxy]- Brustaol Brusatol (NSC 172924) (1R,2S,3S,3aS,3a1R,4R,6aR,7aR,11aS,11bR)-Methyl 1,2,9-trihydroxy-8,11a-dimethyl-4-((3-methylbut-2-enoyl)oxy)-5,10-dioxo-2,3,3a,4,5,6a,7,7a,10,11,11a,11b-dodecahydro-1H-3,3a1-(epoxymethano)dibenzo[de,g]chromene-3-carboxylate (+)-Brusatol Brusatol >=95% (HPLC) Picras-3-en-21-oic acid, 13,20-epoxy-3,11,12-trihydroxy-15-[(3-methyl-1-oxo-2-buten-1-yl)oxy]-2,16-dioxo-, methyl ester, (11β,12α,15β)- Brusato1 100935 methyl (1R,2S,3S,3aS,3a1R,4R,6aR,7aR,11aS,11bR)-1,2,9-trihydroxy-8,11a-dimethyl-4-((3-methylbut-2-enoyl)oxy)-5,10-dioxo-1,4,5,6a,7,7a,10,11,11a,11b-decahydro-2H-3,3a1-(epoxymethano)dibenzo[de,g]chromene-3(3aH)-carboxylate Brusatol, 10 mM in DMSO Brusatol - Bio-X ? 14907-98-3