bruceine A
- CAS No.
- 25514-31-2
- Chemical Name:
- bruceine A
- Synonyms
- NSC31616;Brucein A;bruceine A;NSC 310616;Dihydrobrusatol;Brucea javanica A;Bruceine A 25514-31-2;Bruceine A, 10 mM in DMSO;Bruceine A (Dihydrobrusatol;13,20-Epoxy-3,11β,12α-trihydroxy-15β-(3-methyl-1-oxobutoxy)-2,16-dioxopicras-3-en-21-oic acid methyl ester
- CBNumber:
- CB41382240
- Molecular Formula:
- C26H34O11
- Molecular Weight:
- 522.54
- MDL Number:
- MFCD28167765
- MOL File:
- 25514-31-2.mol
bruceine A price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29936 | Bruceine A | 25514-31-2 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 29936 | Bruceine A | 25514-31-2 | 25mg | $420 | 2024-03-01 | Buy |
| Cayman Chemical | 29936 | Bruceine A | 25514-31-2 | 5mg | $131 | 2024-03-01 | Buy |
| Cayman Chemical | 29936 | Bruceine A | 25514-31-2 | 10mg | $214 | 2024-03-01 | Buy |
| TRC | B689315 | BruceantinA | 25514-31-2 | 25mg | $340 | 2021-12-16 | Buy |
bruceine A Chemical Properties,Uses,Production
Chemical Properties
White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the fruit of bruce chinensis.
Uses
Bruceantin A acts as an anti-babesial quassinoid, extracted from the fruits of Brucea javanica, also an effective anti-trypanosomal agent in vitro. Cytotoxic agent.
Definition
ChEBI: Bruceine A is a quassinoid.
Biological Activity
ic50: 7.7 nm against the parasitescanine babesiosis is a tick-borne disease caused by the intraerythrocytic apicomplexan parasites, babesia gibsoni and b. canis. clinical signs of b. gibsoni infection are anemia, fever, thrombocytopenia, splenomegaly, lymphadenopathy, and lethargy. bruceine a, a natural quassinoid compound extracted from the brucea javanica (l.) merr. dried fruits, was reported to have antibabesial activity.
Physiological effects
Bruisein A has an effect of treating malignant tumor, antimalarial and anti-inflammatory.
in vitro
bruceine a inhibited the in-vitro babesia gibsoni growth in canine erythrocytes at lower concentration compared with the antibabesial drug diminazene aceturate and killed the parasites within 24 hr at a concentration of 25 nm [1].
in vivo
oral administration of bruceine a at a dosage of 6.4 mg/kg/day for 5 days resulted in no clinical findings in a dog. an untreated dog developed typical acute babesiosis symptoms including high fever, severe anemia, and complete loss of appetite and movement. however, the two bruceine a-treated dogs maintained their healthy conditions throughout the experimental period of 4 weeks [1].
target
Antifection | p65 | NF-kB | ROS
References
[1] nakao r, mizukami c, kawamura y, subeki, bawm s, yamasaki m, maede y, matsuura h, nabeta k, nonaka n, oku y, katakura k. evaluation of efficacy of bruceine a, a natural quassinoid compound extracted from a medicinal plant, brucea javanica, for canine babesiosis. j vet med sci. 2009 jan;71(1):33-41.
bruceine A Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253; +8618283602253 | jancyzheng@gcgreenpure.com | China | 953 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29858 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| NanJing Spring & Autumn Biological Engineering CO., LTD. | +8613815430202 | sale02@cqherb.com | CHINA | 376 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
View Lastest Price from bruceine A manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Bruceine A
25514-31-2
|
US $51.00-172.00 / mg | 99.59% | 10g | TargetMol Chemicals Inc. | ||
 |
2022-02-14 | Bruceine A 25514-31-2
25514-31-2
|
US $160.00 / mg | 10mg | >98% by HPLC | 1000.00 kgs | NanJing Spring & Autumn Biological Engineering CO., LTD. | |
 |
2019-07-06 | bruceine A
25514-31-2
|
US $2.00 / kg | 1kg | 99% | 100kg | Career Henan Chemical Co |
-
- Bruceine A
25514-31-2
- US $51.00-172.00 / mg
- 99.59%
- TargetMol Chemicals Inc.
-
- Bruceine A 25514-31-2
25514-31-2
- US $160.00 / mg
- >98% by HPLC
- NanJing Spring & Autumn Biological Engineering CO., LTD.
-
- bruceine A
25514-31-2
- US $2.00 / kg
- 99%
- Career Henan Chemical Co