ChemicalBook >> CAS DataBase List >>alpha,alpha-Diphenyl-4-piperidinomethanol

alpha,alpha-Diphenyl-4-piperidinomethanol

CAS No.
115-46-8
Chemical Name:
alpha,alpha-Diphenyl-4-piperidinomethanol
Synonyms
AZACYCLONOL;ALPHA,ALPHA-DIPHENYL-4-PIPERIDINEMETHANOL;Azacyclanol;alpha,alpha-diphenyl-4-piperidinemethano;mer17;MER 17;Frenquel;Frenoton;Calmeran;MDL 4829
CBNumber:
CB3146211
Molecular Formula:
C18H21NO
Molecular Weight:
267.37
MDL Number:
MFCD00066980
MOL File:
115-46-8.mol
MSDS File:
SDS
Last updated:2024-10-29 11:48:30

alpha,alpha-Diphenyl-4-piperidinomethanol Properties

Melting point 160-163 °C
Boiling point 410.55°C (rough estimate)
Density 1.0449 (rough estimate)
vapor pressure 0Pa at 25℃
refractive index 1.5100 (estimate)
storage temp. Store below +30°C.
solubility Chloroform, Methanol (Slightly, Sonicated)
pka 13.32±0.29(Predicted)
form Solid
color White to light beige
InChIKey ZMISODWVFHHWNR-UHFFFAOYSA-N
CAS DataBase Reference 115-46-8(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 2MMR990PEM
NIST Chemistry Reference Azacyclonol(115-46-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H319
Precautionary statements  P264-P270-P280-P301+P312-P305+P351+P338-P337+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  24/25
WGK Germany  WGK 3 highly water endangering
RTECS  TN0470000
HS Code  29333999
NFPA 704
1
2 0

alpha,alpha-Diphenyl-4-piperidinomethanol price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.14973 Diphenyl-4-piperidinemethanol for synthesis 115-46-8 25g $121 2024-03-01 Buy
TCI Chemical P1369 α-(4-Piperidyl)benzhydrol >99.0%(GC)(T) 115-46-8 5g $39 2024-03-01 Buy
TCI Chemical P1369 α-(4-Piperidyl)benzhydrol >99.0%(GC)(T) 115-46-8 25g $123 2024-03-01 Buy
Alfa Aesar H61281 Diphenyl(4-piperidinyl)methanol, 95% 115-46-8 25g $70.9 2021-12-16 Buy
Alfa Aesar H61281 Diphenyl(4-piperidinyl)methanol, 95% 115-46-8 100g $219 2021-12-16 Buy
Product number Packaging Price Buy
8.14973 25g $121 Buy
P1369 5g $39 Buy
P1369 25g $123 Buy
H61281 25g $70.9 Buy
H61281 100g $219 Buy

alpha,alpha-Diphenyl-4-piperidinomethanol Chemical Properties,Uses,Production

Description

alpha,alpha-Diphenyl-4-piperidinomethanol is an important organic synthetic substance for the synthesis of diphenyl-4-piperidinomethanol. It is also used as a pharmaceutical intermediate in the preparation of terfenadine and Fexofenadine hydrochloride.

Chemical Properties

α,α-Diphenyl-4-piperidinemethanol has the appearance of a white to almost white powder to crystals with a melting point of 163 °C. Store at -20 °C.

Originator

Frenquel,Merrell,US,1955

Uses

α-(4-Piperidyl)benzhydrol is a key intermediate in the synthesis of Fexofenadine (F322490). Fexofenadine EP Impurity E.

Uses

Anxiolytic;H1 antagonist

Definition

ChEBI: Diphenyl(4-piperidinyl)methanol is a diarylmethane.

Manufacturing Process

A mixture of 26 g (0.1 mol) of α-(4-pyridyl)-benzhydrol, 1.5 g of platinum oxide, and 250 ml of glacial acetic acid is shaken at 50-60°C under hydrogen at a pressure of 40-50 lb/in2. The hydrogenation is complete in 2 to 3 hours. The solution is filtered and the filtrate evaprated under reduced pressure. The residue is dissolved in a mixture of equal parts of methanol and butanone and 0.1 mol of concentrated hydrochloric acid is added. The mixture is cooled and filtered to give about 30 g of α-(4-piperidyl)benzhydrol hydrochloride, MP 283- 285°C, as a white, crystalline substance.
The free base is readily obtained from the hydrochloride salt by treatment with ammonia and when so obtained has a melting point of 160-161°C.

brand name

Frenquel (Marion Merrell Dow).

Therapeutic Function

Tranquilizer

498-94-2
108-86-1
115-46-8
Synthesis of alpha,alpha-Diphenyl-4-piperidinomethanol from Isonipecotic acid and Bromobenzene

alpha,alpha-Diphenyl-4-piperidinomethanol Preparation Products And Raw materials

Global( 444)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
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View Lastest Price from alpha,alpha-Diphenyl-4-piperidinomethanol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
alpha,alpha-Diphenyl-4-piperidinemethanol pictures 2024-10-29 alpha,alpha-Diphenyl-4-piperidinemethanol
115-46-8
US $0.00 / kg 20kg 99% 20 tons Qingdao RENAS Polymer Material Co., Ltd.
alpha,alpha-Diphenyl-4-piperidinomethanol pictures 2021-12-14 alpha,alpha-Diphenyl-4-piperidinomethanol
115-46-8
US $26.00 / g 1KG 99% 5ton/Month Qiuxian Baitai New Material Co., LTD
alpha,alpha-Diphenyl-4-piperidinemethanol pictures 2021-07-13 alpha,alpha-Diphenyl-4-piperidinemethanol
115-46-8
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
TIMTEC-BB SBB003057 4-Piperidinemethanol, alpha,alpha-diphenyl- Ataractan Azacyklonol Calmeran Diphenyl(4-piperidinyl)methanol Diphenyl-4-piperidylmethanol Frenoton Frenquel MER 17 mer17 Azacyclonol (base and/or unspecified salts) AZACYCLONOL (ALPHA,ALPHA-DIPHENYL-4-PIPERIDINOMETHANOL) 4-[Hydroxy(diphenyl)methyl]piperidine Diphenyl(piperidin-4-yl)methanol, Azacyclonol, alpha-(Piperidin-4-yl)benzhydrol α-(4-Piperidyl)benzhydrol alpha,alpha-Diphenyl-4-piperidinoMethanol, 98+% 5GR 4-(DiphenylhydroxyMethyl)piperidine MDL 4829 DIPHENYL-4-PIPERIDINEMETHANOL FOR SYNTHE a-(4-Piperidyl)benzhydrol Psychosa α,α-Diphenyl-4-piperidinomethanol a, a- Azacyclonol 4-PiperidineMethanol, a,a-diphenyl- phenyl(4-(piperidin-1-yl)phenyl)methanol ALPHA, ALPHA-DIPHENYL-4-PIPERIDINE METHONOL Diphenyl-4-piperidinemethanol for synthesis α, α-Diphenyl-4-piperidinomethanol, 98+% Psychosan Azacyclonol Base AzacyclonolBase98% ALPHA,ALPHA-DIPHENYL-4-PIPERIDINOMETHANOL ALPHA-(4-PIPERIDYL)BENZHYDROL A,A-DIPHENYL-4-PIPERIDINEMETHANOL 4-(ALPHA,ALPHA DIPHENYL) PIPERIDINE METHANOL 2,2-DIPHENYL-4-PIPERIDONOMETHANOL AZACYCLONAL DIPHENYL-4-PIPERIDINEMETHANOL DIPHENYL-PIPERIDIN-4-YL-METHANOL gamma-pipradol α,α-Diphenyl-4-piperidinylcarbinol alpha,alpha-Diphenyl-4-piperidinomethanol, 98+% alpha,alpha-Diphenyl-4-piperid AZACYCLONOL A , A -DIPHENYL-4-PIPERIDINEMETHANOL Fexofenadine hydrochloride impurity E (EP) Fexofenadine EP Impurity E Terfenadine Impurity 1 Fexofenadine Related Compound E ALPHA ALPHA -DIPHENYL-4-PIPERDINEMETHANO L Fexofenadine Impurity 5(Fexofenadine EP Impurity E) ALPHA, ALPHA-DIPHENYL-4-PIPERIDINE α-(4-Piperidyl)benzhydrol> Diphenyl(piperidin-4-yl)methanol (A 4-Piperidinemethanol, α,α-diphenyl- γ-pipradol α,α-diphenyl-4-piperidinemethanol ALPHA-DIPHENYL-4-PIPERIDINEMETHANOL