alpha,alpha-Diphenyl-4-piperidinomethanol
- CAS No.
- 115-46-8
- Chemical Name:
- alpha,alpha-Diphenyl-4-piperidinomethanol
- Synonyms
- AZACYCLONOL;ALPHA,ALPHA-DIPHENYL-4-PIPERIDINEMETHANOL;Azacyclanol;alpha,alpha-diphenyl-4-piperidinemethano;mer17;MER 17;Frenquel;Frenoton;Calmeran;MDL 4829
- CBNumber:
- CB3146211
- Molecular Formula:
- C18H21NO
- Molecular Weight:
- 267.37
- MDL Number:
- MFCD00066980
- MOL File:
- 115-46-8.mol
- MSDS File:
- SDS
Melting point | 160-163 °C |
---|---|
Boiling point | 410.55°C (rough estimate) |
Density | 1.0449 (rough estimate) |
vapor pressure | 0Pa at 25℃ |
refractive index | 1.5100 (estimate) |
storage temp. | Store below +30°C. |
solubility | Chloroform, Methanol (Slightly, Sonicated) |
pka | 13.32±0.29(Predicted) |
form | Solid |
color | White to light beige |
InChIKey | ZMISODWVFHHWNR-UHFFFAOYSA-N |
CAS DataBase Reference | 115-46-8(CAS DataBase Reference) |
EWG's Food Scores | 1 |
FDA UNII | 2MMR990PEM |
NIST Chemistry Reference | Azacyclonol(115-46-8) |
alpha,alpha-Diphenyl-4-piperidinomethanol price More Price(33)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 8.14973 | Diphenyl-4-piperidinemethanol for synthesis | 115-46-8 | 25g | $121 | 2024-03-01 | Buy |
TCI Chemical | P1369 | α-(4-Piperidyl)benzhydrol >99.0%(GC)(T) | 115-46-8 | 5g | $39 | 2024-03-01 | Buy |
TCI Chemical | P1369 | α-(4-Piperidyl)benzhydrol >99.0%(GC)(T) | 115-46-8 | 25g | $123 | 2024-03-01 | Buy |
Alfa Aesar | H61281 | Diphenyl(4-piperidinyl)methanol, 95% | 115-46-8 | 25g | $70.9 | 2021-12-16 | Buy |
Alfa Aesar | H61281 | Diphenyl(4-piperidinyl)methanol, 95% | 115-46-8 | 100g | $219 | 2021-12-16 | Buy |
alpha,alpha-Diphenyl-4-piperidinomethanol Chemical Properties,Uses,Production
Description
alpha,alpha-Diphenyl-4-piperidinomethanol is an important organic synthetic substance for the synthesis of diphenyl-4-piperidinomethanol. It is also used as a pharmaceutical intermediate in the preparation of terfenadine and Fexofenadine hydrochloride.
Chemical Properties
α,α-Diphenyl-4-piperidinemethanol has the appearance of a white to almost white powder to crystals with a melting point of 163 °C. Store at -20 °C.
Originator
Frenquel,Merrell,US,1955
Uses
α-(4-Piperidyl)benzhydrol is a key intermediate in the synthesis of Fexofenadine (F322490). Fexofenadine EP Impurity E.
Uses
Anxiolytic;H1 antagonist
Definition
ChEBI: Diphenyl(4-piperidinyl)methanol is a diarylmethane.
Manufacturing Process
A mixture of 26 g (0.1 mol) of α-(4-pyridyl)-benzhydrol, 1.5 g of platinum
oxide, and 250 ml of glacial acetic acid is shaken at 50-60°C under hydrogen
at a pressure of 40-50 lb/in2. The hydrogenation is complete in 2 to 3 hours.
The solution is filtered and the filtrate evaprated under reduced pressure. The
residue is dissolved in a mixture of equal parts of methanol and butanone and
0.1 mol of concentrated hydrochloric acid is added. The mixture is cooled and
filtered to give about 30 g of α-(4-piperidyl)benzhydrol hydrochloride, MP 283-
285°C, as a white, crystalline substance.
The free base is readily obtained from the hydrochloride salt by treatment
with ammonia and when so obtained has a melting point of 160-161°C.
brand name
Frenquel (Marion Merrell Dow).
Therapeutic Function
Tranquilizer
alpha,alpha-Diphenyl-4-piperidinomethanol Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | +86-(0)57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
Hangzhou FandaChem Co.,Ltd. | +8615858145714 | FandaChem@Gmail.com | China | 9214 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29882 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2930 | 58 |
Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8618959220845 | sales@amoychem.com | China | 6383 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
View Lastest Price from alpha,alpha-Diphenyl-4-piperidinomethanol manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-10-29 | alpha,alpha-Diphenyl-4-piperidinemethanol
115-46-8
|
US $0.00 / kg | 20kg | 99% | 20 tons | Qingdao RENAS Polymer Material Co., Ltd. | ||
2021-12-14 | alpha,alpha-Diphenyl-4-piperidinomethanol
115-46-8
|
US $26.00 / g | 1KG | 99% | 5ton/Month | Qiuxian Baitai New Material Co., LTD | ||
2021-07-13 | alpha,alpha-Diphenyl-4-piperidinemethanol
115-46-8
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
- alpha,alpha-Diphenyl-4-piperidinemethanol
115-46-8
- US $0.00 / kg
- 99%
- Qingdao RENAS Polymer Material Co., Ltd.
- alpha,alpha-Diphenyl-4-piperidinomethanol
115-46-8
- US $26.00 / g
- 99%
- Qiuxian Baitai New Material Co., LTD
- alpha,alpha-Diphenyl-4-piperidinemethanol
115-46-8
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd