ecallantide
- CAS No.
- 460738-38-9
- Chemical Name:
- ecallantide
- Synonyms
- DX 88;ecallantide;Cys16-Cys40;Cys32-Cys53);ecallantide USP/EP/BP;H-Glu-Ala-Met-His-Ser-Phe-Cys-Ala-Phe-Lys-Ala-Asp-Asp-Gly-Pro-Cys-Arg-Ala-Ala-His-Pro-Arg-Trp-Phe-Phe-Asn-Ile-Phe-Thr-Arg-Gln-Cys-Glu-Glu-Phe-Ile-Tyr-Gly-Gly-Cys-Glu-Gly-Asn-Gln-Asn-Arg-Phe-Glu-Ser-Leu-Glu-Glu-Cys-Lys-Lys-Met-Cys-Thr-Arg-Asp-OH(Disulfide bridge：Cys7-Cys57
- CBNumber:
- CB31508597
- Molecular Formula:
- C305H442N88O91S8
- Molecular Weight:
- 7053.82798
- MDL Number:
- MOL File:
- 460738-38-9.mol
| FDA UNII | 5Q6TZN2HNM |
|---|---|
| ATC code | B06AC03 |
ecallantide Chemical Properties,Uses,Production
Description
Ecallantide, also known as DX-88, was approved in 2009 in the United States for treatment of hereditary angioedema (HAE), a condition characterized by episodic attacks of localized edema in cutaneous and mucosal tissues. HAE results from deficiencies or disorders of C1-esterase inhibitor protein (C1- 1NH). Mutation of the gene that encodes C1-1NH causes the lack or altered activity of the serine protease, C1-1NH. C1-1NH regulates the kallikrein–kinin (contact activation) and complement cascade systems. Ecallantide (DX-88) was designed to inhibit the action of plasma kallikrein. Ecallantide is a potent and selective inhibitor of plasma kallikrein with a Ki= 25 pM. The discovery program that identified ecallantide used phage display technology and a library of designed variants of the first Kunitz domain of TFPI. Ecallantide, a 60-amino acid peptide, with 3-disulfide bonds, differs from TFPI by 7-amino acids. Ecallantide has been developed as a subcutaneous administered formulation.
Originator
Dyax Corp. (United States)
Uses
Treatment of hereditary angioedema; reduction of blood loss during cardiothoracic surgery (plasma kallikrein inhibitor).
brand name
Kalbitor
ecallantide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 616 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10260 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 25961 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 | info@fortunachem.com | China | 5964 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | alfa4@alfachem.cn | China | 13141 | 58 |
| Zhejiang Hangyu API Co., Ltd | +8617531972939 | anna@api-made.com | China | 2944 | 58 |
| CONTIDE BIOTECH CO.,LTD | +852-53358525 | xena@healthtide-api.com | China | 584 | 58 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632 | sales@reading-chemicals.com | China | 15185 | 58 |
| Creative Peptides | info@creative-peptides.com | United States | 6084 | 56 |
View Lastest Price from ecallantide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-08 | ecallantide
460738-38-9
|
US $10.00 / kg | 1kg | 99% | 1000kg | Nantong Guangyuan Chemicl Co,Ltd | |
 |
2023-01-13 | Ecallantide
460738-38-9
|
US $0.00 / g | 1g | 98%min | 1000g | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- ecallantide
460738-38-9
- US $10.00 / kg
- 99%
- Nantong Guangyuan Chemicl Co,Ltd
-
- Ecallantide
460738-38-9
- US $0.00 / g
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD