2-Thiopheneacetyl chloride
- CAS No.
- 39098-97-0
- Chemical Name:
- 2-Thiopheneacetyl chloride
- Synonyms
- SKL1309;AKOS BBS-00003919;2-ThiopheneacetyL;TIMTEC-BB SBB006705;2-Thiopheneacetyl ch;Articaine Impurity 2;Articaine Impurity 11;2-thiophenyl chloride;2-THIENYLACETYL CHLORIDE;Articaine Impurities1823
- CBNumber:
- CB3152140
- Molecular Formula:
- C6H5ClOS
- Molecular Weight:
- 160.62
- MDL Number:
- MFCD00005456
- MOL File:
- 39098-97-0.mol
- MSDS File:
- SDS
| Boiling point | 105-106 °C/22 mmHg (lit.) 130-135 °C/90 mmHg (lit.) |
|---|---|
| Density | 1.303 g/mL at 25 °C (lit.) |
| vapor pressure | 4 mm Hg ( 83 °C) |
| refractive index |
n |
| Flash point | 215 °F |
| storage temp. | 2-8°C |
| form | Liquid |
| color | Clear brown |
| Specific Gravity | 1.303 |
| Water Solubility | Reacts with water. |
| Sensitive | Moisture Sensitive |
| BRN | 114547 |
| InChIKey | AJYXPNIENRLELY-UHFFFAOYSA-N |
| CAS DataBase Reference | 39098-97-0(CAS DataBase Reference) |
| FDA UNII | 3VR2Y6J8UG |
| EPA Substance Registry System | 2-Thiopheneacetyl chloride (39098-97-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 14-34-37-29 | |||||||||
| Safety Statements | 26-28-36/37/39-45-8-30-23 | |||||||||
| RIDADR | UN 3265 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 8-10-21 | |||||||||
| TSCA | T | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29349990 | |||||||||
| NFPA 704 |
|
2-Thiopheneacetyl chloride price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 195995 | 2-Thiopheneacetyl chloride 98% | 39098-97-0 | 25g | $51.78 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.41865 | Thiophene-2-acetyl chloride for synthesis | 39098-97-0 | 25ML | $225 | 2022-05-15 | Buy |
| TCI Chemical | T1751 | Thiophene-2-acetyl Chloride >98.0%(GC)(T) | 39098-97-0 | 25g | $85 | 2024-03-01 | Buy |
| TCI Chemical | T1751 | Thiophene-2-acetyl Chloride >98.0%(GC)(T) | 39098-97-0 | 250g | $469 | 2024-03-01 | Buy |
| Alfa Aesar | L09323 | 2-Thiopheneacetyl chloride, 98% | 39098-97-0 | 25g | $67.65 | 2024-03-01 | Buy |
2-Thiopheneacetyl chloride Chemical Properties,Uses,Production
Description
2-Thiopheneacetyl chloride is used as a reagent to synthesize diamide derivatives of (S)-BINOL. These derivatives display potential anti-inflammatory and anti-arthritis effects. 2-Thiopheneacetyl chloride is also used in the synthesis of Nitrocefin (N493815), a chromogenic substrate that changes colour in the presence of β-lactamases and penicillin-binding proteins.
Chemical Properties
CLEAR BROWN LIQUID
Uses
2-Thiopheneacetyl chloride was used in the synthesis of:
- (S)-ethyl-1-(2-thiopheneacetyl)-3-piperidinecarboxylate, nipecotate-containing immunopotentiator
- 5-fluorouracil-cephalosporin prodrug
- series of new N,N′-di(thiopheneacetyl)diamines derivatives
- 6-β-(thiophen-2′-yl)acetamidomorphine
Uses
2-Thiopheneacetyl chloride was used in the synthesis of (S)-ethyl-1-(2-thiopheneacetyl)-3-piperidinecarboxylate, nipecotate-containing immunopotentiator, 5-fluorouracil-cephalosporin prodrug, series of new N,N?-di(thiopheneacetyl)diamines derivatives and 6-β-(thiophen-2?-yl)acetamidomorphine. Also used in the synthesis of Nitrocefin.
General Description
A clear yellow to dark brown liquid. Insoluble in water and denser than water. Corrosive to skin, and eyes. Vapors severely irritate respiratory tract.
Air & Water Reactions
Insoluble in water. Decomposes exothermically in water yielding fumes of toxic hydrogen chloride.
Reactivity Profile
THIOPHENE-2-ACETYL CHLORIDE is incompatible with water, bases (including amines), with strong oxidizing agents, and with alcohols. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Health Hazard
TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.
Synthesis
In the four-hole boiling flask with mechanical stirring, thermometer, air guide outlet, add 100g 2-thiophene acetic acid; 350g methylene dichloride, stirs and is warming up to 37 DEG C, starts to drip 250g sulfur oxychloride under the protection of nitrogen; within 1.5 hours, drip off insulation reaction 2.5 hours at this temperature.The methylene dichloride of underpressure distillation remnants, continues to distill obtaining 2-thiophen acetyl chloride 102.5g, and yield reaches 91.5%.
2-Thiopheneacetyl chloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8810 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12837 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5857 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20285 | 58 |
| Hebei Mojin Biotechnology Co.,Ltd | +86-15028179902 | angelia@hbmojin.com | China | 1177 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18751 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Hangzhou FandaChem Co.,Ltd. | +8615858145714 | FandaChem@Gmail.com | China | 9116 | 55 |
Related articles
- Synthesis of 2-Thiopheneacetyl chloride
- 2-thiophen acetyl chloride is a kind of important organic synthesis intermediate, is widely used in particularly synthesizing ....
- Feb 16，2022
View Lastest Price from 2-Thiopheneacetyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-29 | 2-Thiopheneacetyl chloride
39098-97-0
|
US $68.00 / Kg/Drum | 500KG | 98% and 99% | 10,000kg per month | Great Innovation (Shanghai) Pharma Co., Ltd., | |
 |
2024-11-19 | 2-Thiopheneacetyl chloride
39098-97-0
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Weibang Biotechnology Co., Ltd | |
 |
2024-10-25 | 2-Thiopheneacetyl chloride
39098-97-0
|
US $0.00 / kg | 1kg | 0.99 | 20tons | Hebei Yanxi Chemical Co., Ltd. |
-
- 2-Thiopheneacetyl chloride
39098-97-0
- US $68.00 / Kg/Drum
- 98% and 99%
- Great Innovation (Shanghai) Pharma Co., Ltd.,
-
- 2-Thiopheneacetyl chloride
39098-97-0
- US $10.00 / KG
- 99%
- Hebei Weibang Biotechnology Co., Ltd
-
- 2-Thiopheneacetyl chloride
39098-97-0
- US $0.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
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