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p-Toluenesulfonic acid monohydrate
- CAS No.
- 6192-52-5
- Chemical Name:
- p-Toluenesulfonic acid monohydrate
- Synonyms
- PTSA;TOLUENE-4-SULFONIC ACID;PTX;PTSA.H2O;4-Methylbenzenesulfonic acid hydrate;TOLUENESULFONIC ACID MONOHYDRATE;PARA TOLUENE SULFONIC ACID;p-Toluenesulfonic acid hydrate;4-TOLUENESULFONIC ACID MONOHYDRATE;PTSA Monohydrate
- CBNumber:
- CB3173385
- Molecular Formula:
- C7H10O4S
- Molecular Weight:
- 190.22
- MDL Number:
- MFCD00142137
- MOL File:
- 6192-52-5.mol
- MSDS File:
- SDS
Last updated:2024-10-30 18:52:02
| Melting point | 96-99 °C(lit.) |
|---|---|
| Boiling point | 140°C 20mm |
| Density | 1,24 g/cm3 |
| vapor density | 5.9 (vs air) |
| refractive index | 1,382-1,384 |
| Flash point | 180 °C |
| storage temp. | Store at +5°C to +30°C. |
| solubility | H2O: 0.1 g/mL, clear |
| Colour Index | 42655 |
| form | Solid |
| color | White to pink |
| PH | 1 (650g/l, H2O, 20℃)(anhydrous substance) |
| Water Solubility | soluble |
| Sensitive | Hygroscopic |
| Merck | 14,9533 |
| BRN | 3568023 |
| Stability | Stable. Incompatible with strong oxidizing agents, strong bases, most common metals. Protect from moisture. |
| InChIKey | KJIFKLIQANRMOU-UHFFFAOYSA-N |
| CAS DataBase Reference | 6192-52-5(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 3BTO78GAFF |
| EPA Substance Registry System | Benzenesulfonic acid, 4-methyl-, monohydrate (6192-52-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H290-H314-H335-H412 | |||||||||
| Precautionary statements | P234-P260-P273-P280-P303+P361+P353-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,C | |||||||||
| Risk Statements | 36/37/38-34-37 | |||||||||
| Safety Statements | 26-37-45-36/37/39 | |||||||||
| RIDADR | UN 2585 8/PG 3 | |||||||||
| WGK Germany | - | |||||||||
| RTECS | XT6300000 | |||||||||
| F | 3 | |||||||||
| Autoignition Temperature | 600 °C | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29041000 | |||||||||
| Toxicity | LD50 orally in Rabbit: 2570 mg/kg | |||||||||
| NFPA 704 |
|
p-Toluenesulfonic acid monohydrate price More Price(67)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | TX0770 | p-Toluenesulfonic Acid, Monohydrate GR ACS | 6192-52-5 | 500g | $150 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.14725 | Toluene-4-sulfonic acid monohydrate for synthesis | 6192-52-5 | 100g | $28.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.14725 | Toluene-4-sulfonic acid monohydrate for synthesis | 6192-52-5 | 1kg | $75 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.14725 | Toluene-4-sulfonic acid monohydrate for synthesis | 6192-52-5 | 5kg | $264 | 2024-03-01 | Buy |
| Sigma-Aldrich | 27815 | p-Toluenesulfonic acid monohydrate ≥99% (calc. to H2O free subst.) | 6192-52-5 | 1kg | $62.5 | 2024-03-01 | Buy |
p-Toluenesulfonic acid monohydrate Chemical Properties,Uses,Production
Chemical Properties
White crystals
Uses
p-Toluenesulfonic acid monohydrate (p-TsOH·H2O) may be used as a catalyst in the synthesis of the following:
- Unsymmetrical benzils.
- Highly substituted piperidines.
- 1,3,5-Trisubstituted benzenes by trimerization of alkynes.
- Triazoloquinazolinone and benzimidazoquinazolinone derivatives.
- 1,3,5-Trisubstituted pyrazoles derivatives.
- Selenated ketene dithioacetals.
Uses
Derivitizing agent.
Uses
p-Toluenesulfonic acid monohydrate is used as a catalyst in the synthesis of resveratrol, in oxane derivatives as an antimalarial agent, as substituted piperidine and unsymmetrical benzyl. It acts as a catalyst in the preparation of 1,3,5-trisubstituted pyrazoles derivatives, selenated ketene dithioacetals, triazoloquinazolinone and benzimidazoquinazolinone derivatives. It also serves as an intermediate in the esterification and in reductive amination reactions.
General Description
p-Toluenesulfonic acid monohydrate, an oxonium salt, is an inexpensive and easy to handle organic catalyst used in organic synthesis. The study of its crystalline structure shows that it is monoclinic with P21/c space group. Its solubility in aqueous sulfuric acid solutions has been studied.
Purification Methods
Purify the acid by precipitation from a saturated solution at 0o by introducing HCl gas. It can also be crystallised from conc HCl, then crystallised from dilute HCl (charcoal) to remove benzenesulfonic acid. It has been crystallised from EtOH/water. Dry it in a vacuum desiccator over solid KOH and CaCl2. p-Toluenesulfonic acid can be dehydrated by azeotropic distillation with *benzene or by heating at 100o for 4hours under water-pump vacuum. The anhydrous acid can be crystallised from *benzene, CHCl3, ethyl acetate, anhydrous MeOH, or from acetone by adding a large excess of *benzene. It can also be dried under vacuum at 50o. The S-benzylisothiuronium salt has m 182o (from aqueous EtOH). [Beilstein 11 IV 241.]
p-Toluenesulfonic acid monohydrate Preparation Products And Raw materials
Raw materials
Preparation Products
4-[4-(BROMOMETHYL)PHENYL]-1,2,3-THIADIAZOLE
Pyridinium p-Toluenesulfonate
Methyl glycolate
Ethyl (R)-2-hydroxy-4-phenylbutyrate
Saquinavir
LENAMPICILLIN
2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ACETIC ACID
Clemizole
Doxifluridine
1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone
Cefoperazone
4-[4-(TRIFLUOROMETHYL)PHENYL]-1,2,3-THIADIAZOL-5-AMINE
4-PYRIDINEETHANETHIOL HYDROCHLORIDE
4-(4-METHOXYPHENYL)-1,2,3-THIADIAZOL-5-AMINE
4-(1,2,3-THIADIAZOL-4-YL)BENZYLAMINE HYDROCHLORIDE
1of5
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Related articles
- What is p-Toluenesulfonic acid monohydrate?
- p-Toluenesulfonic acid monohydrate is an organic-soluble acid catalyst in organic synthesis. The catalyst has been incorporate....
- Apr 26，2021
View Lastest Price from p-Toluenesulfonic acid monohydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-28 | p-Toluenesulfonic acid monohydrate
6192-52-5
|
US $6.00 / KG | 1KG | 99% | 20TONS | Hebei Longbang Technology Co., Ltd | |
 |
2024-11-28 | p-Toluenesulfonic acid monohydrate
6192-52-5
|
US $100.00-75.00 / kg | 1kg | 99% | 5000Ton | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2024-11-28 | p-Toluenesulfonic acid monohydrate
6192-52-5
|
US $6.00 / kg | 1kg | 99% | 2000KG/Month | HebeiShuoshengImportandExportco.,Ltd |
-
- p-Toluenesulfonic acid monohydrate
6192-52-5
- US $6.00 / KG
- 99%
- Hebei Longbang Technology Co., Ltd
-
- p-Toluenesulfonic acid monohydrate
6192-52-5
- US $100.00-75.00 / kg
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- p-Toluenesulfonic acid monohydrate
6192-52-5
- US $6.00 / kg
- 99%
- HebeiShuoshengImportandExportco.,Ltd
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