Doxifluridine
- CAS No.
- 3094-09-5
- Chemical Name:
- Doxifluridine
- Synonyms
- flutron;5'-DFUR;5'DFURD;furtulon;AMC 0101;5-F-5‘-dU;RO-21-9738;5-cl-5'-dU;Doxifluidine;DOXIFLURIDINE
- CBNumber:
- CB4461786
- Molecular Formula:
- C9H11FN2O5
- Molecular Weight:
- 246.19
- MDL Number:
- MFCD00866530
- MOL File:
- 3094-09-5.mol
Melting point | 188-192 °C(lit.) |
---|---|
alpha | D25 +18.4° (c = 0.419 in water) |
Density | 1.3751 (estimate) |
refractive index | 20 ° (C=1, H2O) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 7.4(at 25℃) |
color | White |
Merck | 14,3437 |
CAS DataBase Reference | 3094-09-5(CAS DataBase Reference) |
FDA UNII | V1JK16Y2JP |
NCI Drug Dictionary | doxifluridine |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H317 | |||||||||
Precautionary statements | P261-P272-P280-P302+P352+P333+P313+P363-P501 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36-24/25 | |||||||||
WGK Germany | 2 | |||||||||
RTECS | YU7526000 | |||||||||
Hazard Note | Irritant | |||||||||
HazardClass | IRRITANT, IRRITANT-HARMFUL | |||||||||
HS Code | 29349990 | |||||||||
Toxicity | LD50 (14 day) in mice or rats (mg/kg): >1000 i.v.: >2000 s.c.; in male, female mice, male, female rats (mg/kg): >5000, >5000, 3471, 3390 orally (Shimizu) | |||||||||
NFPA 704 |
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Doxifluridine price More Price(60)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | F8791 | 5-Fluoro-5′-deoxyuridine | 3094-09-5 | 25MG | $86.6 | 2023-06-20 | Buy |
Sigma-Aldrich | Y0001644 | Capecitabine impurity B European Pharmacopoeia (EP) Reference Standard | 3094-09-5 | Y0001644 | $218 | 2023-06-20 | Buy |
Sigma-Aldrich | F8791 | 5-Fluoro-5′-deoxyuridine | 3094-09-5 | 100MG | $267 | 2023-06-20 | Buy |
Sigma-Aldrich | F8791 | 5-Fluoro-5′-deoxyuridine | 3094-09-5 | 250MG | $466 | 2023-06-20 | Buy |
Sigma-Aldrich | PHR2850 | 5′-deoxy-5-fluorouridine certified reference material, pharmaceutical secondary standard | 3094-09-5 | 50MG | $452 | 2022-05-15 | Buy |
Doxifluridine Chemical Properties,Uses,Production
Description
Doxifluridine is a prodrug derivative of 5-fluorouracil (5-FU). As an antineoplastic it is more potent than 5-FU in the treatment of breast, stomach, colon and rectal cancers.
Chemical Properties
White Solid
Originator
Hoffmann-LaRoche (USA)
Uses
antineoplastic, pyrimidine antimetabolite
Uses
A prodrug of 5-Flurouridine. A fluorinated pyrimidine nucleoside with cytostatic activity
Uses
An antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes. A metabolite of Capecitabine
Uses
5’-Deoxy-5-fluorouridine is a metabolite of the chemotherapeutic agent Capecitabine (C175650). 5’-Deoxy-5-fluorouridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes.
Definition
ChEBI: A pyrimidine 5'-deoxyribonucleoside that is 5-fluorouridine in which the hydroxy group at the 5' position is replaced by a hydrogen. It is an oral prodrug of the antineoplastic agent 5-fluorouracil. Designed to circumvent the rapid degradation of 5-fluoro racil by dihydropyrimidine dehydrogenase in the gut wall, it is converted into 5-fluorouracil in the presence of pyrimidine nucleoside phosphorylase.
brand name
Furtulon
Biochem/physiol Actions
Doxifluridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts transformed by H-ras or trk oncogenes. Possesses anticachectic activity which is independent of its antiproliferative activity.
Doxifluridine Preparation Products And Raw materials
Raw materials
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Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | 1057@dideu.com | China | 3921 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9332 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 906 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from Doxifluridine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2024-08-22 | 5-Fluoro-5′-deoxyuridine
3094-09-5
|
US $0.00 / g | 1g | ≥98.0% | 10kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
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2024-08-05 | Doxifluridine
3094-09-5
|
US $1.00 / KG | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd | |
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2022-05-14 | Doxifluridine
3094-09-5
|
US $1.10 / g | 1g | 99.9% Min | 100 Tons | Dideu Industries Group Limited |
-
- 5-Fluoro-5′-deoxyuridine
3094-09-5
- US $0.00 / g
- ≥98.0%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Doxifluridine
3094-09-5
- US $1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- Doxifluridine
3094-09-5
- US $1.10 / g
- 99.9% Min
- Dideu Industries Group Limited
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